The stuff I use has MSM in the glucosamine and chondroitin. But it probably doesn't give me as much MSM as the single ingredient MSM. You've got me wondering if all I need is the MSM.Ive been using the vitamin shoppe brand. It's a powder so I can take a lot. I ended up dropping the cissus and the glucosamine and chondritin and the relief remained from just the MSM. Its not too expensive for how uch you get and I think it gets ridiculously cheap on Amazon.