Progesterone Dose for Men

[Cataceous]

A number of guys have reported good results ordering hCG through AllDayChemist.com or ReliableRxPharmacy.com. If you search the forum you'll find some of the particular brands mentioned, which include Zyhcg, Ovidac and Fertigyn.

Interestingly, with the right kind of pregnancy test you can get an idea of the potency of your hCG. It's discussed in this thread:

Testing HCG potency with pregnancy test / Buying HCG in liquid form

www.excelmale.com

 

[Gman86]

What’s everyone’s thoughts on timing of prog? It seems to be common that people take prog at night because of its conversion into allopregnenolone, and allopregnenolone being a positive modulator of GABA, but prog can also convert into cortisol. Is there an argument to possibly use prog in the morning, due to its possible conversion into cortisol? @Cataceous @Gianluca

Seems like quite a few guys say that pregnenolone gives them energy, and therefore they take in in the am. I wonder if this increase in energy has anything to do with preg converting into prog, and then prog increasing their cortisol levels

 

[Cataceous]

What’s everyone’s thoughts on timing of prog? It seems to be common that people take prog at night because of its conversion into allopregnenolone, and allopregnenolone being a positive modulator of GABA, but prog can also convert into cortisol. Is there an argument to possibly use prog in the morning, due to its possible conversion into cortisol? @Cataceous @Gianluca
...

Probably an individual thing. I always find progesterone to be sedating, meaning bedtime dosing makes sense.

 

[Gianluca]

What’s everyone’s thoughts on timing of prog? It seems to be common that people take prog at night because of its conversion into allopregnenolone, and allopregnenolone being a positive modulator of GABA, but prog can also convert into cortisol. Is there an argument to possibly use prog in the morning, due to its possible conversion into cortisol? @Cataceous @Gianluca

Seems like quite a few guys say that pregnenolone gives them energy, and therefore they take in in the am. I wonder if this increase in energy has anything to do with preg converting into prog, and then prog increasing their cortisol levels

I don’t think it works that way, generally cortisol peaks in the am and goes down at night, it doesn’t mean that if you take Prog at night it will convert into cortisol immediately, in order words, I believe circadian rhythm is what dictates the production of cortisol. However, taking Pregnenolone at night, for my self can be a hit or miss, it is ether calming or it does feel like producing a energy similar to cortisol.

I now do well with the Progesterone cream 12.5mg at night, I actually felt last week I lost some benefits on sleep and calmness during the day I noticed in the beginning, I may try to go up in dose. My Progesterone serum in the am came back at .4 on the Labcorp scale

 

[JA Battle]

I don’t think it works that way, generally cortisol peaks in the am and goes down at night, it doesn’t mean that if you take Prog at night it will convert into cortisol immediately, in order words, I believe circadian rhythm is what dictates the production of cortisol. However, for myself taking Pregnenolone at night can be a hit or miss, it is ether calming or it does feel like producing a energy similar to cortisol.

I now do well with the Progesterone cream 12.5mg at night, I actually felt last week I lost some benefits on sleep and calmness during the day I noticed in the beginning, I may try to go up in dose. My Progesterone serum in the am came back at .4 on the Labcorp scale

Can you remind me of your full protocol?

 

[Gianluca]

Can you remind me of your full protocol?

.13 daily IM test CYP, but need to go to .15
Just lowered my NP thyroid to 1/4 from half grain
50mg Pregnenolone cream
12.5mg Progesterone cream
1-3mg melatonin

this is just the HRT stuff

 

[MarcoFL]

.13 daily IM test CYP, but need to go to .15
Just lowered my NP thyroid to 1/4 from half grain
50mg Pregnenolone cream
12.5mg Progesterone cream
1-3mg melatonin

this is just the HRT stuff

I am curious how .25 of a grain does anything. I am trying to go by my FT3 and RT3. when I am on 2 grains and have 3.1 FT3 and 8 RT3 with TSH around 0.06 and FT4 of .7 I wonder if I need to cut back given I notice a bump in heart rate. What do you manage your dose to? FT3? TSH? symptoms? Thank you!

 

[JA Battle]

I am curious how .25 of a grain does anything. I am trying to go by my FT3 and RT3. when I am on 2 grains and have 3.1 FT3 and 8 RT3 with TSH around 0.06 and FT4 of .7 I wonder if I need to cut back given I notice a bump in heart rate. What do you manage your dose to? FT3? TSH? symptoms? Thank you!

What is the heart rate?

 

[MarcoFL]

What is the heart rate?

Kind of confusing. I had been on 50mg of Metoprolol for 6 months. I am 59 wanted a cardiologist relationship so my first meeting he said Bystolic is the best for heart rate control. I went to 5mg Bystolic but not quite enough so I added back 25mg of Metoprolol for now until I meet with him this week to go up to 10mg Bystolic. I am 59 with a slight high HR can run 80 on nothing and 150-80 on BP. I have lowered my T dose to 12mg per day and trying to figure out thyroid of 2 grains per day. I cannot tell if I get much benefit with 2 vs 1. I highly recommend the Bystolic over anything else. I think there is some Sildenifil in it for vasodilation. My doctor said only down side is the price of $170 per month. I think a generic is about $40 however. My HR runs 60-70, BP 120-70 now on this. Feels very smooth.

 

[JA Battle]

Kind of confusing. I had been on 50mg of Metoprolol for 6 months. I am 59 wanted a cardiologist relationship so my first meeting he said Bystolic is the best for heart rate control. I went to 5mg Bystolic but not quite enough so I added back 25mg of Metoprolol for now until I meet with him this week to go up to 10mg Bystolic. I am 59 with a slight high HR can run 80 on nothing and 150-80 on BP. I have lowered my T dose to 12mg per day and trying to figure out thyroid of 2 grains per day. I cannot tell if I get much benefit with 2 vs 1. I highly recommend the Bystolic over anything else. I think there is some Sildenifil in it for vasodilation. My doctor said only down side is the price of $170 per month. I think a generic is about $40 however. My HR runs 60-70, BP 120-70 now on this. Feels very smooth.

Do you notice immediate erectile quality changes from manipulating hr and blood pressure?

 

[MarcoFL]

Do you notice immediate erectile quality changes from manipulating hr and blood pressure?

yes it is quite noticeable to HR and BP.I just feel better! No issues with erection quality. I do take about 9 grams of Citrulline a day.

 

[Gianluca]

I am curious how .25 of a grain does anything. I am trying to go by my FT3 and RT3. when I am on 2 grains and have 3.1 FT3 and 8 RT3 with TSH around 0.06 and FT4 of .7 I wonder if I need to cut back given I notice a bump in heart rate. What do you manage your dose to? FT3? TSH? symptoms? Thank you!

Sorry I have been busy traveling. I manage my dose based on FT3 level and symptoms. I used to use 1 grain to bring my FT3 to 4.0, but since starting using Lugols Iodine, I obtained same FT3 level with only half grain. During the last consult with provider we decided to cut a 1/4 and see how am I doing. With out NP thyroid my FT3 seats are 3.0, so I assume a 1/4 grain would take it to 3.5, in the low optimal.

 

[Gman86]

Sorry I have been busy traveling. I manage my dose based on FT3 level and symptoms. I used to use 1 grain to bring my FT3 to 4.0, but since starting using Lugols Iodine, I obtained same FT3 level with only half grain. During the last consult with provider we decided to cut a 1/4 and see how am I doing. With out NP thyroid my FT3 seats are 3.0, so I assume a 1/4 grain would take it to 3.5, in the low optimal.

How much lugol’s u using per day? U using 2% or 5%?

 

[Gianluca]

How much lugol’s u using per day? U using 2% or 5%?

2% diluted to 1% one drop daily

 

[DixieWrecked]

I love that this thread has gotten so huge. What a great resource for progesterone discussion.

I still find that the days I use progesterone cream, my Fitbit sleep score is much higher and I feel .much more rested the next day.

 

[JA Battle]

I love that this thread has gotten so huge. What a great resource for progesterone discussion.

I still find that the days I use progesterone cream, my Fitbit sleep score is much higher and I feel .much more rested the next day.

I remember you tried hydrogel. Are you still on hydrogel? What’s full protocol? How often do
You use progesterone? What is its impact on sexual function

 

[Gman86]

2% diluted to 1% one drop daily

2% is 2.5mg of iodine per drop, so 1% would be 1.25mg per drop. I’m currently taking 1 drop of 2% per day myself. So 2.5mg/ day

 

[Gman86]

I love that this thread has gotten so huge. What a great resource for progesterone discussion.

I still find that the days I use progesterone cream, my Fitbit sleep score is much higher and I feel .much more rested the next day.

I’m really loving using progesterone this time around. I feel like it definitely added something that my body needed and was missing. Can’t wait to get labs done and dial in my dose more. Haven’t had labs yet while using this brand of inj prog. But so far 1mg/ night seems to be working well

 

[DixieWrecked]

I remember you tried hydrogel. Are you still on hydrogel? What’s full protocol? How often do
You use progesterone? What is its impact on sexual function

No I am not on hydrogel anymore. Feeling quite depressed at the moment actually. Anhedonia is getting pretty real. Despite all the anabolics in my system my gym gains are probably worse that if had less because my mind isn't right and my workouts are somewhat lame. I am currently on an EOD protocol. I enjoy the feeling progesterone gives me and allows me to sleep though.

200 TC weekly
100 ND Weekly
500iu HCG on Monday

I would have bailed on this protocol by now but I will be getting bloodwork any day now and didn't want to tinker. I'll most likely try something with a much lower TC dose probably around 70mg a week.

 

[BillyJ03z]

I just read through this entire thread and it was like reading a Thriller novel.. so many highs and lows... and at the end of this novel now I feel low.... smdh

Since starting TRT about 11 years ago (currently 48 yrs old), I have never once had the great feeling. My sleep is horrible, I have constant depression (up and down), lost interest in a lot of things I used to enjoy doing as I have no motivation to do anything, my libido is up and down (mostly down) but can still perform and I rely on viagra as a crutch, and now even more depressed because hair loss has kicked in which I was never prepared for. I just recently (last week) started Buproprion SR at 200 mg's per day to help with depression and I don't feel shit ( I know it's been only a week...)

I was hoping in the beginning of this thread that Progesterone was the missing piece, but it seems like the excitement has faded. I've had stints where I took Pregnenelone at varying doses but I never noticed any benefit or negative. Ive took DHEA and it definitely raised my low DHEA-S to the upper range but I never noticed any benefit physically from it... I've tried HCG and all it seemed to do was raise my estrogen and had no physical benefit. Regardless, I am going through my past 12 years of blood work to see if I had any pre-trt progesterone, preg, dhea lab tests to see what I was..

If anything, I'm thinking that since Progesterone is a 5ar inhibitor then maybe I can use the transdermal cream on my head for hairloss..