Do u apply it right before bed?
Ur dose is 20mg correct?
So ur HCG dose was 350iu’s/ week before progesterone, and now it’s 245iu’s/ week? Do u even notice benefits at such low doses?
Progesterone’s effect on prolactin
- Thread starter Gman86
- Start date
Ur dose is 20mg correct?
So ur HCG dose was 350iu’s/ week before progesterone, and now it’s 245iu’s/ week? Do u even notice benefits at such low doses?
I'm a bit skeptical. Even the most direct path is circuitous and would be reflected in higher testosterone. Progesterone is also an aromatase inhibitor. Personally I've seen no correlation between my progesterone dose and the serum level of estradiol.
I'm a bit skeptical. Even the most direct path is circuitous and would be reflected in higher testosterone. Progesterone is also an aromatase inhibitor. Personally I've seen no correlation between my progesterone dose and the serum level of estradiol.
progesterone will impact e2’s activity within tissues. for a period of time this may raise serum e2 until such time that the body’s production and clearance of e2 adjusts.
I'd be interested in learning about specific cases in which estradiol's metabolism is disrupted in this manner. Presumably these effects have to be indirect because "Progesterone lacks undesirable off-target hormonal activity, in contrast to various progestins. As a result, it is not associated with androgenic, antiandrogenic, estrogenic, or glucocorticoid effects."[R]
anestizzle
Member
Yes one pump (20mg) applied before bed to the scrotum. I’ve had a love hate relationship with HCG. Too high of a dose I get ED, followed by tiredness and poor training performance, to anxiety. No HCG and I lack penile sensitivity. It seems like most times when I have felt “off” or those symptoms I skip a dose and they resolve. HCG has been a trial and error for me. I’m on test cream, test cyp injections, HCG, and no AI. Progesterone has definitely made me feel like what was missing is coming back. It was like there was some sort of disconnect between my penis and my brain. I know that sounds strange but my libido was never the same since starting TRT 3 years ago. It’s bringing back that “primal” urge to have to get myself off now. Before I could I just rarely feel that “deep in my loins need” of that makes any sense. I just feel a lot more “normal” now
No it definitely makes sense. What’s ur full protocol with dosages? Ur on test cream and injections?
anestizzle
Member
I do two clicks of the test 200mg/mL cream two clicks to the scrotum twice daily. Test Cyp 20mg IM EOD. HCG 80IU subQ EOD. Progesterone 20mg/pump. One pump to the scrotum at bed time. No AI. I also take Cialis 10mg daily and Macuna Pruriens two capsules daily.
i suspect that adding progesterone to a deficient person can reverse engineer a state estradiol control through modulation of prolactin/dopamine and cortisol.
Prolactin and I think cortisol lead to upregulation of estrogen receptors. Progesterone’s effect on prolactin and cortisol leads to down regulation of e2 receptors leading to this potential increase in circulating estrogens.
as far as the temporary increase in estradiol, I’d say that it would probably only be noticeable with less than ideal ability of the liver to take fat soluble estrogens and convert them to water soluble forms to be excreted depending on the individuals liver, systemic estrogen load and the amount of progesterone being introduced.
it’s likely much more complicated I’m sure
Estradiol increases thyroid binding globulin. Therefore progesterone increases free thyroid hormones through its opposition of estrogen. As we know, many overlapping positive feedback loops go into creating this.
things that short circuit the positive feedback loops are estrogens, cortisol, and prolactin. I’m not saying these need be crushed to low levels. But as we see in healthy young subjects, high androgens, low estrogens, and adrenals that have not yet been exhausted.
The thing is various nutrients are needed in the enzymatic processes that make it all happen. IMO nutrient imbalance is likely a huge culprit in many of us being here. But that is deeper topic that we know even less about. I say imbalance because a deficiency in one mineral can cause a toxicity in another. And their metabolism is intertwined. And from Food, albeit the only safe way to restore balance, it takes time to shift the ratios. This is hard to prescribe a solution because there is even less of a timely feedback than there is with supplementing hormones. And testing schemes to diagnose is not anywhere near definitive.
DixieWrecked
Well-Known Member
I know what you mean. I lost that primal drive to do just about anything. Workouts were lame. My work at my job was lame. No desire to pursue women at all. I know I have only been on progesterone for a few days but i feel really damn good. My penis is hanging normally. I just had a beastly workout. I'm sleeping well. I am defientely going to stick with it and your success story brings me even more optimism.
I’ve been on the pregnenolone cream at 50mg daily in the morning for about a month, and have being doing the progesterone cream at a lower dose at night on the scrotum. Preg cream helps a lot with mood and energy, and gives me similar feelings of being on cortisol replacement without the downsides. Progesterone cream down there makes me calmer but I can’t say it’s done as much.
I’ve been on a cut for about a month and lost around 10lbs and have felt fine all things considered, whereas usually while cutting I feel horrid. My free test and E2 remain skyrocketed for unknown reasons, but I’m going in for bloodwork in a few weeks to see if bringing my thyroid dose down will help with that.
Can’t say for sure but I don’t seem to respond well to pregnenolone pills.
I’ve been on a cut for about a month and lost around 10lbs and have felt fine all things considered, whereas usually while cutting I feel horrid. My free test and E2 remain skyrocketed for unknown reasons, but I’m going in for bloodwork in a few weeks to see if bringing my thyroid dose down will help with that.
Can’t say for sure but I don’t seem to respond well to pregnenolone pills.
Where do u apply the preg cream in the morning?
How many mg’s of progesterone cream do u apply to ur scrotum at night? Do u apply it right before bed, or a few hours prior?
First question: What is the mechanism of opposition? Second: Is this situation analogous to estradiol's influence on SHBG? If so then the free hormone may be regulated independently and changes in the amount of the binding globulin only influence the total hormone level, e.g. total testosterone, while the more important free hormone level is not affected.
Holy shit, what are your test levels on that dose? Just 2 clicks to my scrotum alone has my test levels off the charts.
What’s ur progesterone dose? How many mg’s?
Oh sorry I thought I wrote that, it’s 40mg of the cream.
Wow that seems like a decently high dose of prog cream compared to others that are using it. No issues at this dose? Ever had progesterone checked while on the prog cream?
I’d say that the opposition in multi faceted. There seems to be a link between progesterones reduction of prolactin and down regulating estrogen receptors. The opposition of the actual productions of estrogens seems possible to be mediated through modulation of cortisol in either its secretion/secretion pattern and or its metabolism. I’m not sure. Cortisol has a place in increasing aromatase activity most likely through insulin/blood sugar dysregulation. Neurotransmitters are also involved. Metabolically, things flow in both directions. Nervous system effects hormones, hormones effect nervous system.
Concerning number two, I’m not sure. Interestingly, thyroid hormone replacement increases shbg in many as well. Is estradiol just at the scene of the crime in these increases in shbg and tbg or is it causative? Also, are these binding hormones simply just transporters essentially to the most important target tissues as we know that receptor activation is what allows hormones to exert their beneficial or detrimental effects?
I didn’t think much of it and it’s two pumps of the tube. I’d used it in the past on my skin and I just felt calm from it. Never had that checked but I’ll be going in for labs within a month or so and might add all that to the panel.
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