Pregnenolone makes high dose Testosterone tolerable

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Dave Lee explains that a Pregnenolone deficiency doesn't allow for higher testosterone dosages to be tolerated.
Supplementing Pregnenolone is an easy fix instead of lowering your testosterone levels.

 

Ahhh! I misunderstood your question! Free T range is 35-155.

I was surprised my E2 wasn’t higher either. I do not touch AI’s and I’m not taking EQ which can lower E2. My SHBG is on the lower end of the range at 12.

But yeah man, I feel excellent. The best I have felt in long time. It took months of experimenting and I have finally found that sweet spot. I will stick with this protocol.

I am going to be adding some deprenyl in a few weeks and see how that goes. I’m taking it for the life extension benefits and of course as a sort of nootropic.

Have u ever taken high doses of an ai in the past? Or high doses of DHT derivatives? I just can’t believe ur E2 is 25! Lol. What was ur total T and E2 prior to starting TRT? Maybe ur just the lowest aromatizer on the planet lol

do u mind linking the pregnenolone product ur using?

Deprenyl is definitely a super interesting compound. Me and @Cataceous are the only 2 members that have experimented with it, as far as I know. He still takes it, I believe. I didn’t notice any benefits from it, so I ended up discontinuing it. I was only using a fairly small dose tho, IIRC. Would love to hear ur experience on it once u start

 

At 250mg's/week (125mgs x 2 injections) my TT is at 1503 ng/dl and my FT is at 731.4 pg/ml. I was noticing my resting heart rate was increasing by about 10bpm's. Nothing to be alarmed about but I could feel my heart rate wasn't quite what it was

I began to take 50mgs pregnenolone/day and 25 mgs DHEA/day. It helped a little bit. Some days were better than others. I upped my dose to 100mgs Preg/day and 50mgs DHEA/day and BINGO. My resting heart rate returned and I felt excellent with high TT and FT levels. I never felt bad at these levels mind you, but I thought I'd feel much better. I just felt slightly "off"

My program/dosages are finally dialed in in regards to HCG, Test, DHEA, Pregnenolone. Libido and sense of well being is off the charts. Never felt better.

Hey man, how would you say cardio is? How has it been affected by the addition of preg/dhea? If you don’t do cardio then I guess during sex how is cardio?

 

Have u ever taken high doses of an ai in the past? Or high doses of DHT derivatives? I just can’t believe ur E2 is 25! Lol. What was ur total T and E2 prior to starting TRT? Maybe ur just the lowest aromatizer on the planet lol

do u mind linking the pregnenolone product ur using?

Deprenyl is definitely a super interesting compound. Me and @Cataceous are the only 2 members that have experimented with it, as far as I know. He still takes it, I believe. I didn’t notice any benefits from it, so I ended up discontinuing it. I was only using a fairly small dose tho, IIRC. Would love to hear ur experience on it once u start

I have never messed with AI’s because I am very aware of their pitfalls. I don’t abuse AAS when I cycle. For example the last cycle I did ended 3 months ago. I was on 200mgs test cyp/week, Tren E 200mgs/week and 20mgs Superdrol/day. I did Superdrol for 4 weeks and Test Cyp and Tren for 15 weeks. Only problem I had was My prolactin shot up. I knocked it down with Caber for a 2.5 weeks and then never had an issue after that. I’m lucky when it comes to side effects from taking androgens but then again I don’t take crazy doses. I do convert to a crap ton of DHT but that is the extent of it. Pregnenolone posted below.

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My TT when I first started TRT 20 years ago was 82 lol. That was a nightmare. I was clueless as to what was wrong with me but I knew something wasn’t right. That’s a whole other story. I don’t even know what my E2 was back then, I didn’t have the knowledge to even request that and the doctors probably didn’t either.

I’ll keep you posted on Deprenyl. I only got a 3 month supply to see if it does anything. I’ll start with 2.5mgs/day then move up to 5mg/day and see what happens.

 

Hey man, how would you say cardio is? How has it been affected by the addition of preg/dhea? If you don’t do cardio then I guess during sex how is cardio?

I do both hahahaha.

I haven’t noticed a negative or positive impact on my cardiovascular system from taking it.

 

I have never messed with AI’s because I am very aware of their pitfalls. I don’t abuse AAS when I cycle. For example the last cycle I did ended 3 months ago. I was on 200mgs test cyp/week, Tren E 200mgs/week and 20mgs Superdrol/day. I did Superdrol for 4 weeks and Test Cyp and Tren for 15 weeks. Only problem I had was My prolactin shot up. I knocked it down with Caber for a 2.5 weeks and then never had an issue after that. I’m lucky when it comes to side effects from taking androgens but then again I don’t take crazy doses. I do convert to a crap ton of DHT but that is the extent of it. Pregnenolone posted below.

Search - Life Extension

Use the search field to find vitamins, supplements, and health information to help you live a better life.

www.lifeextension.com

My TT when I first started TRT 20 years ago was 82 lol. That was a nightmare. I was clueless as to what was wrong with me but I knew something wasn’t right. That’s a whole other story. I don’t even know what my E2 was back then, I didn’t have the knowledge to even request that and the doctors probably didn’t either.

I’ll keep you posted on Deprenyl. I only got a 3 month supply to see if it does anything. I’ll start with 2.5mgs/day then move up to 5mg/day and see what happens.

Hope you understand that this is a men's health/hrt forum and we do not discuss cycling, blasting/cruising AAS for the sole purpose of muscle enhancement which has absolutely nothing to do with maintaining long-term health!

Superdrol let alone Tren has no place on here!

There are numerous steroid forums littered on the internet to discuss such.

 

That’s what I figured. Here’s the lab range for quest’s free T lab (46.0-224.0). Sometimes it only goes up to 155.0, but years ago they only ever used the range that goes up to 224.0. I’m sure they lowered it as men have gotten sicker and sicker. So I always go by their original range that goes up to 224.0. So ur free T is about 3 1/4 times the top end of their range. But if ur feeling great, I wouldn’t change a thing!

But how is ur E2 only 25? That seems almost impossible considering where ur total and free T values are. It’s just very hard for me to believe that’s accurate

Also what’s ur SHBG level? It must be in the single digits, or close to it

You have no clue where your FT level truly sits as you never had it tested using the most accurate assays.....gold standard Equilibrium Dialysis or Ultrafiltration!

 

Hope you understand that this is a men's health/hrt forum and we do not discuss cycling, blasting/cruising AAS for the sole purpose of muscle enhancement which has absolutely nothing to do with maintaining long-term health!

Superdrol let alone Tren has no place on here!

There are numerous steroid forums littered on the internet to discuss such.

Apologies I had no idea. I’m new and while that is no excuse it won’t happen again.

Thank you for the heads up!

 

Ahhh! I misunderstood your question! Free T range is 35-155.

I was surprised my E2 wasn’t higher either. I do not touch AI’s and I’m not taking EQ which can lower E2. My SHBG is on the lower end of the range at 12.

But yeah man, I feel excellent. The best I have felt in long time. It took months of experimenting and I have finally found that sweet spot. I will stick with this protocol.

I am going to be adding some deprenyl in a few weeks and see how that goes. I’m taking it for the life extension benefits and of course as a sort of nootropic.

At 250mg's/week (125mgs x 2 injections) my TT is at 1503 ng/dl and my FT is at 731.4 pg/ml. I was noticing my resting heart rate was increasing by about 10bpm's. Nothing to be alarmed about but I could feel my heart rate wasn't quite what it was

I began to take 50mgs pregnenolone/day and 25 mgs DHEA/day. It helped a little bit. Some days were better than others. I upped my dose to 100mgs Preg/day and 50mgs DHEA/day and BINGO. My resting heart rate returned and I felt excellent with high TT and FT levels. I never felt bad at these levels mind you, but I thought I'd feel much better. I just felt slightly "off"

My program/dosages are finally dialed in in regards to HCG, Test, DHEA, Pregnenolone. Libido and sense of well being is off the charts. Never felt better.

Even if you never posted the testing method for FT with a sky-high trough TT 1503ng/dL your trough FT level would be absurdly high even if you had high/highish SHBG.

Unfortunately in your cases, your SHBG is absurdly low 12 nmol/L most likely due to your high dosed T protocol 250 mg/week (125 mg every 3.5 days) let alone other AAS you have been using and seeing as you are hitting a trough TT 1500s you can be rest assured your trough FT levels are through the f**king roof!

Peak levels are going to be higher.

Luckily you had FT tested using one of the most accurate assays Equilibrium Dialysis (reference range 35-155 pg/mL) and you can clearly see that your trough FT is ridiculously high 731.4 pg/mL.

 

Apologies I had no idea. I’m new and while that is no excuse it won’t happen again.

Thank you for the heads up!

All good my man just want to give you a heads up.

 

Even if you never posted the testing method for FT with a sky-high trough TT 1503ng/dL your trough FT level would be absurdly high even if you had high/highish SHBG.

Unfortunately in your cases, your SHBG is absurdly low 12 nmol/L most likely due to your high dosed T protocol 250 mg/week (125 mg every 3.5 days) let alone other AAS you have been using and seeing as you are hitting a trough TT 1500s you can be rest assured your trough FT levels are through the f**king roof!

Peak levels are going to be higher.

Luckily you had FT tested using one of the most accurate assays Equilibrium Dialysis (reference range 35-155 pg/mL) and you can clearly see that your trough FT is ridiculously high 731.4 pg/mL.

I’ve been “clean” for 3 months and only on Test Cyp but I believe you are right in regards to the low SHBG being due to the high dose of test.

 

Luckily you had FT tested using one of the most accurate assays Equilibrium Dialysis (reference range 35-155 pg/mL) and you can clearly see that your trough FT is ridiculously high 731.4 pg/mL.

Wow. Good everyday fT level .

 

Ahhh! I misunderstood your question! Free T range is 35-155.

I was surprised my E2 wasn’t higher either. I do not touch AI’s and I’m not taking EQ which can lower E2. My SHBG is on the lower end of the range at 12.

But yeah man, I feel excellent. The best I have felt in long time. It took months of experimenting and I have finally found that sweet spot. I will stick with this protocol.

I am going to be adding some deprenyl in a few weeks and see how that goes. I’m taking it for the life extension benefits and of course as a sort of nootropic.

I've taken deprenyl (selegiline). It will increase your T even further (via increasing dopamine).

 

I've taken deprenyl (selegiline). It will increase your T even further (via increasing dopamine).

Really? I did not know that (raises T levels). Are you still taking it? Let me know the pro's/con's (if any) of your experience. Dosing as well. 1mg/day, 2.5mg/day, 5mg/day?

I'm very interested in your experience with it. Why you stopped (if applicable) etc etc.

 

@bumpy what time of day are u taking the preg and DHEA?

Are u able to open the life extension pregnenolone capsules? Jc incase I were to get them and wanted to start off with a little lower of a dose, but didn’t want to buy the lower dose capsules

 

Really? I did not know that (raises T levels). Are you still taking it? Let me know the pro's/con's (if any) of your experience. Dosing as well. 1mg/day, 2.5mg/day, 5mg/day?

I'm very interested in your experience with it. Why you stopped (if applicable) etc etc.

Dopamine and testosterone have a bidirectional relationship. My 23andme shows that I have a gene variant wherein I do not breakdown dopamine as quickly as the normal person, so when I took selegiline it made my already high dopamine levels even higher. I cut my T cyp dose and yet my t levels went higher. High dopamine also means high norepinephrine which affects EQ, heart rate and BP. I stopped taking it because it affected my EQ, increased heart rate and BP. I have a gene variant that you may not have, so it may not affect you like it did me.

 

@bumpy what time of day are u taking the preg and DHEA?

Are u able to open the life extension pregnenolone capsules? Jc incase I were to get them and wanted to start off with a little lower of a dose, but didn’t want to buy the lower dose capsules

I take the pregnenolone first thing in the morning (empty stomach). 45 minutes later I eat breakfast and take DHEA. My second dose of DHEA comes around 5pm.

I do not have the bottle of pregnenolone with me but i do believe they are the capsules you can pull apart. Worst case scenario if they are not, you can cut them open. They are not small capsules so getting access to the powder will be easy.

Please keep me updated how this protocol goes for you once you feel like you’ve got it dialed in. I’m very interested to see how it works out for you. I’ve had great success on it, so I hope you find yourself in the same boat. Nothing better when people get dialed in and feel fantastic.

 

Dopamine and testosterone have a bidirectional relationship. My 23andme shows that I have a gene variant wherein I do not breakdown dopamine as quickly as the normal person, so when I took selegiline it made my already high dopamine levels even higher. I cut my T cyp dose and yet my t levels went higher. High dopamine also means high norepinephrine which affects EQ, heart rate and BP. I stopped taking it because it affected my EQ, increased heart rate and BP. I have a gene variant that you may not have, so it may not affect you like it did me.

what dose were you on?

 

I take the pregnenolone first thing in the morning (empty stomach). 45 minutes later I eat breakfast and take DHEA. My second dose of DHEA comes around 5pm.

I do not have the bottle of pregnenolone with me but i do believe they are the capsules you can pull apart. Worst case scenario if they are not, you can cut them open. They are not small capsules so getting access to the powder will be easy.

Please keep me updated how this protocol goes for you once you feel like you’ve got it dialed in. I’m very interested to see how it works out for you. I’ve had great success on it, so I hope you find yourself in the same boat. Nothing better when people get dialed in and feel fantastic.

Thanks so much for the reply. And I feel the exact same way. I love seeing guys finally figuring out how to get dialed in and feel fantastic on HRT. I’ll save this thread and definitely give an update when I do end up adding pregnenolone to my protocol.

 

what dose were you on?

2.5 mg MWF. It has a long half life.

 

2.5 mg MWF. It has a long half life.

Also, the high conversion of dopamine into the more excitory catecholamines is regulated by gaba. Pregnenolone-progesterone pathway is a strong amplifier of gaba signaling. I believe I’m in this same boat as you although I have not had the dna testing to verify it. I’m pretty high strung as we call it.