Pregnenolone – By Gene Devine

[Storm]

I've always felt wonderful on trt. I really don't know if I'm receiving any benefit from supplementing with Pregnenolone and dhea. But I really enjoy my protocol and the whole try experience.

Hey Vince do you have a full list of the supplements you take each day, doses, and timing? Do you know if I would need to supplement DHEA if my DHEA is in range according to labcorp's range ? I'm 29 and I'm at 275.3 on the blood test for DHEA sulfate (range is 138.5 -472.5).

Thanks

 

[TRT7]

I was tried pregnenolone and it gives me anexiety.

 

[Vince]

Hey Vince do you have a full list of the supplements you take each day, doses, and timing? Do you know if I would need to supplement DHEA if my DHEA is in range according to labcorp's range ? I'm 29 and I'm at 275.3 on the blood test for DHEA sulfate (range is 138.5 -472.5).

Thanks

Looking at your lab range I would have to say no. I like to use DHEA because I normally have low estradiol levels but when I supplement with DHEA it brings my estradiol levels into a good healthy range.

 

[joshmaximus]

It has a calming effect because it activates receptor sites in brain cells for GABA (itself a calming agent), enabling more GABA to be absorbed by the cells.

Gene what supplents do u take? Is there a thread on what all u take am interested.

 

[G1122]

I had labs that show no detectable (0) pregnenalone as well as progesterone with a DHEA-S level of 194.0ug/dL (0 - 650). This was while I was on TRT (on clomid now without much success - high LH, low T...). Wondering why (as far as I can tell) there isn't much research in men on pregnenalone/dhea supplementation as an alternative to TRT, it seems there's an upstream cause. I see one study commonly referenced that concluded DHEA supplementation increases T in women, but not in men, but that study only had 9 65+ year old men. What about a subpopulation of younger men that don't have adequate levels?? If I don't have adequate precursor hormones how is my body supposed to make adequate T?

 

[Vince Carter]

Pregnenolone is a typically unreliable test and can be more pricey than other tests where a better one is Progesterone which is just one rung down the ladder, and is cheaper. A "good" Progesterone test can infer the Preg is good enough.

 

[G1122]

Pregnenolone is a typically unreliable test and can be more pricey than other tests where a better one is Progesterone which is just one rung down the ladder, and is cheaper. A "good" Progesterone test can infer the Preg is good enough.

Thanks for the tip! They happened to run a Progesterone lab, too, and it was also 0 (undetected).

I'm going for an ACTH stimulation test, I've had low cortisol values, too. Curious how this pathway could create secondary hypogonadism, but wouldn't be surprised.