Pregnenolone & DHEA, any of you guys taking them and seeing benefits?

[trtthings]

I have a bottle of 100mg pregnenolone tablets at home and took the first one this morning. Other than that I've no experience with it myself.

 

[trtthings]

Looks like maybe the 100mg pregnenolone was a mistake, I feel like it's giving me anxiety.

I thought what John Crisler had to say on it here was interesting, regarding transdermal being superior to the tablets: SHR # 2071 :: Pregnenolone the Progenitor Hormone ::

 

[PhilM7]

I tried both DHEA and the Pregnenolone cream and I couldn't tell a difference. With that said, I have had different results with DHEA in the past. About 20 years ago, when DHEA benefits first came into the news for me, I brought a brand at the drugstore and discovered that it put me into a deep coma like sleep at night. It was wonderful. When the bottle was empty, I tossed it out, not remembering what brand it was. I went to the drugstore later, and I brought what I thought was the last brand I had, in the same mg dosage, but it did nothing, and didn't make me sleep well. I have never had that positive experience with DHEA since then. I may try another brand in the future. Everybody reacts differently to meds and supplements, so your results may vary.

 

[Nelson Vergel]

There are some interesting posts here

pregnenolone

www.excelmale.com

 

[antelopers]

I like the idea of pregnenolone, but even 10mg makes me groggy and slow for 2 days

 

[trtthings]

I like the idea of pregnenolone, but even 10mg makes me groggy and slow for 2 days

I wonder if it has to do with transdermal > oral as Crisler mentioned in the podcast.

 

[Vince]

I take Pregnenolone 10 mg and 25 mg of DHEA. It brings my dhea levels in a good range. Also helps to increase my estrogen levels, which normally are low.

 

[trtthings]

Can't say for sure if it was the pregnenolone, but been highly emotional & on the verge of crying today. Can't say I'm looking to repeat it.

 

[52hoosier]

I take both at Defy's recommendation. Evidently, the DHEA is helping to lower my SHBG and raising my Free T. That's what Defy tells me.

 

[xqfq]

My firsthand, unscientific reports:

Before I was on TRT, taking even a small amount of DHEA would make me feel incredible. "Like the first day of summer" is the best way to describe it. I haven't really experimented with DHEA in a controlled fashion since being on TRT.

I did an experiment where I mega-dosed pregnenolone. I took 30mg three times a day. It felt amazing. There was constant spring in my step. The reason I started the experiment was I read a paper about how mega-dosing pregnenolone was being trialed as a "cure for loneliness" by researchers[1]. But it was a temporary experiment, so I stopped.[2]

1. I wasn't lonely, but I was interested in the effect.
2. And I suspect that these temporary changes in hormones can, by virtue of the *change* itself, maybe cause some kind of mental effect. E.g. some guys feel best between dose changes.

 

[Match]

Aceito ambas as recomendações de Defy. Evidentemente, o DHEA está ajudando a diminuir meu SHBG e aumentar meu T. Livre. Isso é o que Defy me diz.

Fez exames que confirmam que DHEA reduziu seu SHBG? Quais seus valores antes e após, por gentileza?

 

[ERO]

I take oral DHEA 10mg and apply pregnenolone cream 10mg before bed to help me sleep. That's the only benefit I have ever noticed from either or both of them - they help me sleep better and not awaken at 3-4 am and not be able to get back to sleep.

 

[McBeavy]

Do you take both of them before bed? When you say sleep better, do you mean longer or is the quality of your sleep improved?

 

[ERO]

Yes, both before bed. I have sleep issues where I go to sleep fine and sleep good, but wake up at like 3:00 AM, wide awake and unable to get back to sleep until about the time I need to get up for work at 6:00.

These two supplements allow me or help me to sleep until the alarm goes off most nights.

 

[jmjmjm]

I’m taking DHEA. No negative effects to report. Not sure about the positives. I feel good with my current protocol.

 

[Zibernet]

Pregnenolone makes me depressed at any dose.
DHEA, on the other hand, gives me a mental boost and swells my penis like nothing else.

 

[DonaldPump2020]

I always feel like pregnenolone lowers my e2 (i already have low e2 symptoms for whatever reason) even more, or it raises progesterone which antagonizes e2 receptors.

I like its benzo'esque calming effect via progesterone/allopregnanolone but cant seem to find a dose that works.

I use DHEA 25-50mg a day, split into 2 doses if.
I feel like it improves anxiety after taking it for some time, but doesnt fix my low e2

 

[Dano]

I use DHEA plus from Douglas Labs. 25mg of DHEA and 25mg of pregnanolone, one capsule before bed. I sleep good, wake up feeling energized and it seems to be helping with my lower T symptoms as I have not started TRT yet (sex drive decent, morning wood and mild ED symptoms are gone). Using this as I'm low-normal T range now, 52 yrs old and in generally good health. May move forward and reach out to Defy but this is helping me for now...

 

[Zibernet]

I use DHEA plus from Douglas Labs. 25mg of DHEA and 25mg of pregnanolone, one capsule before bed. I sleep good, wake up feeling energized and it seems to be helping with my lower T symptoms as I have not started TRT yet (sex drive decent, morning wood and mild ED symptoms are gone). Using this as I'm low-normal T range now, 52 yrs old and in generally good health. May move forward and reach out to Defy but this is helping me for now...

Have you tried DHEA on its own to see what's doing what?

 

[Dano]

Have you tried DHEA on its own to see what's doing what?

I haven't tried that... My DHEA levels were in the lower end of the range before I started this formulation. I figured with a lower/normal T the pregnenolone added on would help backfill the channels. Haven't had T levels tested since starting this but I feel better and symptoms have improved.