Pregnenolone and Progesterone for Men: Pharmacokinetics and Studies

[JA Battle]

That guys body is probably irreparably damaged. This blows my mind. Has he ever gotten bloodwork?

I don’t think so, sad to see. But for now he feels like Zeus apparently. Talking to and watching this guy was an interesting experience. Quite entertaining honestly. Alpha to the max haha. He was completely open with me about what he’s been doing too which was cool. But I worry for some people...

 

[Montrealer]

View attachment 14631

I just got my pre-pregnenolone supplementation level (by LC/MS assay). My pregnenolone test level was 11 ng/dL (Quest "normal" range 22-237 ng/dL). I will retest in a few weeks after taking 100 mg every night. My progesterone test level (immunoassay) was 0.7 ng/mL (no range given). Let's see how much progesterone increases due to pregnenolone supplementation.

Nelson, do you observe any positive changes in your mood, sense of wellbeing since you started taking Pregnenolone?

 

[Nelson Vergel]

Nelson, do you observe any positive changes in your mood, sense of wellbeing since you started taking Pregnenolone?

I always wait at least 4 weeks to make conclusions since the placebo effect can last a while. I would say I am sleeping more deeply and waking up less tired so far. No extra bloating.

I will get my lab test results (preg, prog, etc) next week after supplementing 100 mg preg every night for the past 3 weeks. I have baseline levels to compare.

 

[Nelson Vergel]

What’s the reference range for the progesterone LC/MS test through discounted labs?

I will let you know in a week. They do not show it on their description page.

Quest Diagnostics: Test Directory

testdirectory.questdiagnostics.com

 

[JA Battle]

It’s <1.4 ng/ml

 

[Gman86]

It’s <1.4 ng/ml

Not the biggest fan of the < ranges, but at least it’s in the same unit of measurement as labcorp, ng/ml. Labcorp’s range is currently 0.0-0.5 ng/ml. So labcorp just prefers guys be in a lower range. But I’ve heard that labcorp’s range used to be 0.0-1.0. And I’ve heard that it’s healthy to have progesterone levels up to 1.2 ng/ml, as a male. So as long as the units of measurement are the same u can do ur own research and figure out where u want to be. So quest’s progesterone LC/MS would definitely be a viable option to test progesterone, and probably preferred over labcorp’s LC/MS progesterone test and their funky lab range for it

 

[JA Battle]

Not the biggest fan of the < ranges, but at least it’s in the same unit of measurement as labcorp, ng/ml. Labcorp’s range is currently 0.0-0.5 ng/ml. So labcorp just prefers guys be in a lower range. But I’ve heard that labcorp’s range used to be 0.0-1.0. And I’ve heard that it’s healthy to have progesterone levels up to 1.2 ng/ml, as a male. So as long as the units of measurement are the same u can do ur own research and figure out where u want to be. So quest’s progesterone LC/MS would definitely be a viable option to test progesterone, and probably preferred over labcorp’s LC/MS progesterone test and their funky lab range for it

This is what I was thinking. How is your progesterone supplementation going?

 

[Gman86]

This is what I was thinking. How is your progesterone supplementation going?

So I started taking 2mg injected subQ before bed on 5-7-21. Got labs done on 6-3-21. Results were 1.6 (0.0-0.5) ng/ml. I started at a level around 0.2-0.3. So I then dropped my dose to 1mg subQ before bed, and just had labs done on 6-24-21. Results should be back by the end of this week

But I ended up stopping the progesterone the day I got my labs done. I inject at night, so my last injection was before bed the night before I had labs done, and that was the last injection I did. I just didn’t notice any benefits from it. And I noticed that it was harder to finish. When I was with my gf it just took more effort to finish and took longer. When I was by myself I would get to the point where I would feel like I was gonna finish, and then wouldn’t. Which wasn’t normal at all for me. 2 days after discontinuing the progesterone I was finally able to finish without any issues. So it was definitely the progesterone causing that. So overall I just didn’t notice any benefits, and it just messed with me sexually a bit. I think it decreased my sensitivity a bit, possible decreased my libido a very tiny bit, and maybe made erections a little more difficult to get when I was by myself. With my gf I didn’t seem to have any issues. I’m nandrolone, which does something to progesterone receptors, as far as I know, so maybe with the nandrolone it was just overkill. Not entirely sure tbh. I just know that even on 1mg/ day subQ I was only experiencing negatives, and no positives that I was aware of

 

[Gianluca]

Study done in post menopausal women, but it shows how Oral Progesterone converts to Allopregnenolone in humans. I head dr Mark Gordon saying that who fails with Pregnenolone to increase ALLO, should try Progesterone

(PDF) Pharmacokinetics of progesterone and its metabolites allopregnanolone and pregnanolone after oral administration of low-dose progesterone

PDF | To investigate the pharmacokinetics of progesterone, allopregnanolone and pregnanolone after treatment with a low oral dose of progesterone. Eight... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

 

[GreenMachineX]

Great thread. Haven't started my pregnenolone trial yet. I have the weirdest side effects from everything and the overstimulation (like a wide open, brain-pressure) I'm getting currently I'm afraid to make worse. I think it's from the sublingual dhea building up since that's the only thing new and I believe 25mg oral dhea caused it several years ago. I've determined I need dhea though because it actually lowers my blood pressure and obviously helps with nitric oxide production for me (in gym and bedroom workouts lol). Maybe pregnenolone could rebalance the overstimulation from dhea? I have sublingual and capsule. I'm so prone to anxiety and being high strung.

 

[Nelson Vergel]

Maybe pregnenolone could rebalance the overstimulation from dhea? I have sublingual and capsule. I'm so prone to anxiety and being high strung.

You have nothing to lose. I would start at 100 mg nightly and see how you feel. It may have some calming effect on you.

 

[Nelson Vergel]

Study done in post menopausal women, but it shows how Oral Progesterone converts to Allopregnenolone in humans. I head dr Mark Gordon saying that who fails with Pregnenolone to increase ALLO, should try Progesterone

(PDF) Pharmacokinetics of progesterone and its metabolites allopregnanolone and pregnanolone after oral administration of low-dose progesterone

PDF | To investigate the pharmacokinetics of progesterone, allopregnanolone and pregnanolone after treatment with a low oral dose of progesterone. Eight... | Find, read and cite all the research you need on ResearchGate

www.researchgate.net

"To investigate the pharmacokinetics of progesterone, allopregnanolone and pregnanolone after treatment with a low oral dose of progesterone. Eight postmenopausal women were given a single oral dose of 20 mg of micronised progesterone on Day 1 and 20 mg twice daily on Days 2-7. Blood samples for the analysis of progesterone, allopregnanolone and pregnanolone were collected, and pharmacokinetic parameters were calculated. After ingestion of a single dose, areas under the plasma concentration-time curve (AUC) from 0 to 12 h for progesterone, allopregnanolone and pregnanolone were 127%, 196% and 119% higher than the corresponding AUCs estimated to be caused by endogenous production. The maximum plasma concentration (Cmax) and the AUC values were significantly lower for pregnanolone than for progesterone and allopregnanolone. The trough concentrations at steady state (Css) were significantly higher than the baseline values, and Css for pregnanolone was significantly lower than for allopregnanolone and progesterone. Css for allopregnanolone was in the range of what is normally seen in the menstrual cycle. After ingestion of a low-dose of progesterone, the concentrations of allopregnanolone were in the same range as those of progesterone. Oral doses of 20 mg of progesterone twice daily to postmenopausal women produced allopregnanolone concentrations comparable to those achieved physiologically in premenopausal women. Low-dose oral progesterone may be used as a prodrug to allopregnanolone when the aim is to investigate low-dose allopregnanolone effects in humans."

I wonder when researchers will look at progesterone dosing in men on TRT to "achieve physiologically progesterone levels comparable to those in healthy men not on TRT".

 

[GreenMachineX]

You have nothing to lose. I would start at 100 mg nightly and see how you feel. It may have some calming effect on you.

Well, I hear what you mean by "nothing to lose", but if the opposite happened and it amplified the stimulation, I would have a complete freak out lol.

 

[Gianluca]

"To investigate the pharmacokinetics of progesterone, allopregnanolone and pregnanolone after treatment with a low oral dose of progesterone. Eight postmenopausal women were given a single oral dose of 20 mg of micronised progesterone on Day 1 and 20 mg twice daily on Days 2-7. Blood samples for the analysis of progesterone, allopregnanolone and pregnanolone were collected, and pharmacokinetic parameters were calculated. After ingestion of a single dose, areas under the plasma concentration-time curve (AUC) from 0 to 12 h for progesterone, allopregnanolone and pregnanolone were 127%, 196% and 119% higher than the corresponding AUCs estimated to be caused by endogenous production. The maximum plasma concentration (Cmax) and the AUC values were significantly lower for pregnanolone than for progesterone and allopregnanolone. The trough concentrations at steady state (Css) were significantly higher than the baseline values, and Css for pregnanolone was significantly lower than for allopregnanolone and progesterone. Css for allopregnanolone was in the range of what is normally seen in the menstrual cycle. After ingestion of a low-dose of progesterone, the concentrations of allopregnanolone were in the same range as those of progesterone. Oral doses of 20 mg of progesterone twice daily to postmenopausal women produced allopregnanolone concentrations comparable to those achieved physiologically in premenopausal women. Low-dose oral progesterone may be used as a prodrug to allopregnanolone when the aim is to investigate low-dose allopregnanolone effects in humans."

I wonder when researchers will look at progesterone dosing in men on TRT to "achieve physiologically progesterone levels comparable to those in healthy men not on TRT".

I still think most men on TRT will need to look at oral Pregnenolone supplementation to restore physiologically level on Progesterone. Oral Progesterone for men is a good tool for anxiety/sleep, when raising Progesterone through Pregnenolone supplementation won't work for that purpose

 

[Zibernet]

I still think most men on TRT will need to look at oral Pregnenolone supplementation to restore physiologically level on Progesterone. Oral Progesterone for men is a good tool for anxiety/sleep, when raising Progesterone through Pregnenolone supplementation won't work for that purpose

Yes, most of us would have to supplement Pregnenolone.
But it has nothing to do with backfilling the pathways, and everything to do with being deficient even before TRT.
If we are low on T, why wouldn't we be low on Pregnenolone and DHEA?

Before TRT my Pregnenolone was below the bottom of the range, and my brain tremendously benefited from supplementing.

 

[Zibernet]

I am reintroducing pregenolone topically suspended in dmso at 2mg on scrotum every 8 hours.

I do this because my stint of running dhea and progesterone has me in what I would describe as a “gaba dominant” state. I’m happy and don’t care about anything! Including sex and work. I’m professionally chilling

does anyone know any information relating to how much pregnenolone an adult male endogenously secretes daily? Also is it in a diurnal fashion?

on another note but not to change the course of the thread, I was with a buddy last night at a bar and he is like 6’ 180 at 7% bodyfat. He has been on 200mg test e and 200mg tren e for 5 years straight! He looks like a cartoon. And the aggression he has socially is insane. Too bad it will be short lived for him and he doesn’t notice or care.

Do you have a recent pic of him?
That makes me curious.

When you say aggressive, is that in a good way?

 

[Gianluca]

Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation - PubMed

The steroid pregnenolone (P) and its sulfate (PS) can accumulate in the central nervous system independent of peripheral sources. Pharmacologically, the sulphated form of P interacts with the GABAA receptor complex, and functional assays show that this steroid behaves as an allosteric GABAA...

pubmed.ncbi.nlm.nih.gov

Abstract​

The steroid pregnenolone (P) and its sulfate (PS) can accumulate in the central nervous system independent of peripheral sources. Pharmacologically, the sulphated form of P interacts with the GABAA receptor complex, and functional assays show that this steroid behaves as an allosteric GABAA receptor antagonist. The present study explored the effect of a single dose of P upon the sleep-EEG and concurrent secretion of growth hormone and cortisol in male volunteers. P increased the amount of time spent in slow wave sleep and depressed EEG sigma power. Sleep-associated nocturnal cortisol and growth hormone secretion remained unchanged, ruling out the possibility that P exerted its effect via altered regulation of these hormones. Furthermore, results from in vitro studies on the potency of P to activate gene transcription via corticosteroid receptors made a genomic action of P via hormone receptor-sensitive DNA sequences unlikely. We conclude that P acts in a non-genomic fashion at or in the vicinity of the benzodiazepine binding site, modulating allosterically the GABAA receptor like a partial inverse.

 

[camygod]

I don’t think so, sad to see. But for now he feels like Zeus apparently. Talking to and watching this guy was an interesting experience. Quite entertaining honestly. Alpha to the max haha. He was completely open with me about what he’s been doing too which was cool. But I worry for some people...

shame he needs to use tren to feel that way
the damage to his brain will be awful
all just for sheer vanity

 

[SSHSSA74]

How much do you take? I tried it for a while but I retained too much water. It may be worth another try.

I have been taking 100 mg pregnenolone every night for a week. It may be too early to tell (placebo effect?), but I am sleeping well and my mood and energy have improved. Let's see if this effect is only happening by chance!

I am also taking iron plus vitamin C (1000 mg) to improve my low ferritin (it was 34 when I lasted checked)

I’m on 25 mg topical per night. And same here. Better sleep and mood for sure, which I really like, but I think it gives me ED even while on low to moderate dose of cialis.

 

[bumpy]

So I started taking 2mg injected subQ before bed on 5-7-21. Got labs done on 6-3-21. Results were 1.6 (0.0-0.5) ng/ml. I started at a level around 0.2-0.3. So I then dropped my dose to 1mg subQ before bed, and just had labs done on 6-24-21. Results should be back by the end of this week

But I ended up stopping the progesterone the day I got my labs done. I inject at night, so my last injection was before bed the night before I had labs done, and that was the last injection I did. I just didn’t notice any benefits from it. And I noticed that it was harder to finish. When I was with my gf it just took more effort to finish and took longer. When I was by myself I would get to the point where I would feel like I was gonna finish, and then wouldn’t. Which wasn’t normal at all for me. 2 days after discontinuing the progesterone I was finally able to finish without any issues. So it was definitely the progesterone causing that. So overall I just didn’t notice any benefits, and it just messed with me sexually a bit. I think it decreased my sensitivity a bit, possible decreased my libido a very tiny bit, and maybe made erections a little more difficult to get when I was by myself. With my gf I didn’t seem to have any issues. I’m nandrolone, which does something to progesterone receptors, as far as I know, so maybe with the nandrolone it was just overkill. Not entirely sure tbh. I just know that even on 1mg/ day subQ I was only experiencing negatives, and no positives that I was aware of

What is your nandrolone protocol ie dosage, 1 injection/week? 2 split doses? I have a bunch on hand and haven’t started it yet. I’m thinking of using 100mg week, but I just haven’t pulled the trigger yet because I’m feeling excellent and don’t want to muddy the waters so to speak.