We discussed the pros and cons. A few years ago, back in Maryland, with this urologist, I was taking 30 mg, Test E, IM, daily. My libido was strong, but few if any erections and I was already overweight for me, I went from 155 to 170 and my E2 sensitive was 60 pg. I totally subscribed to not using an AI. My decision, not my doctor Maybe that was a mistake. Everytime I hit a brick wall, I learn, but I get banged up, too. I'm just stumbling along trying to feel better,overall, and get my penis to work. My doctor is great and I'm his problem patient. @ggenovez reports great results from taking .5 mg anastrazole, daily, as part of his testosterone protocol. @Gman86 posted reports from three guys who also took enough AI to drive E2 way down and they experienced great improvements. Totally contradictory from what we know at the moment. If this doesn't work the only other option is to take estradiol tablets to push E2 higher.
@MIP1950, I think your approach is reasonable. Trust your doctor, go with his recommendations and see how you feel. You can adjust from there.
I personally think I feel shitty with high E2, but as many have pointed out, high E2 and low E2 symptoms overlap, so it can be a really hard thing to track. This is part of the reason why I never really stuck to an AI, even though I have been prescribed anastrazole several times in the past. I figured it's hard enough to chase one hormone in testosterone, let alone two.
All that said, I am giving anastrozole a try along with testosterone injections. I promise, I have been as much of a problem patient as you. I have struggled with multiple forms of TRT, even though I also feel wiped out off it. My latest theory is that if I could get testosterone and minimize downstream metabolites, I may feel better than I have in the past with injections. I started a trial of Xyosted and anastrazole this week. So far, going fine. Will report back here.
By the way, I have used Natesto on an off for years. It is an excellent option if you can't get this figured out.
I personally think I feel shitty with high E2, but as many have pointed out, high E2 and low E2 symptoms overlap, so it can be a really hard thing to track. This is part of the reason why I never really stuck to an AI, even though I have been prescribed anastrazole several times in the past. I figured it's hard enough to chase one hormone in testosterone, let alone two.
All that said, I am giving anastrozole a try along with testosterone injections. I promise, I have been as much of a problem patient as you. I have struggled with multiple forms of TRT, even though I also feel wiped out off it. My latest theory is that if I could get testosterone and minimize downstream metabolites, I may feel better than I have in the past with injections. I started a trial of Xyosted and anastrazole this week. So far, going fine. Will report back here.
By the way, I have used Natesto on an off for years. It is an excellent option if you can't get this figured out.
My urologist and I had(and always have)interesting conversations. He's also puzzled by why a man would improve with an E2 <5 pg but he acknowledged that it likely is related to the hypothalamus. Since we're operating blind, so to speak, I think all theories are on the table.
Regarding Natesto, I don't think it's covered by my insurance. I might be able get a STEP waiver, since I've been on injections, pellets and compounded cream. Even with that it would probably still be expensive but I'd try it. Right now, back to basics; 100 mg Test E, IM, weekly and now will add anastrazole. We have to keep trying. Sometimes, by science, and serendipity, we find a protocol that works!
Fernando Almaguer
Well-Known Member
Is your name pronounced.. dick's erect? lol
Hahah Fernando good eye!!!
DixieWrecked
Well-Known Member
This thread was good but now its great. For me at least.
That’s actually pretty damn funny. Never figured it out. This thread is officially great.
Same. Can’t believe it took this long lol
Ikr!!!! Haha
DixieWrecked
Well-Known Member
Ha. I love this place. You guys are cracking me up.
Back to experimenting with anastrazole. Bloated and feeling lousy. Last evening(7 pm) took 1 mg. Sleep was lousy, in a bad mood this morning, BUT, around 9 am, my libido took off, lots of sex fantasies which brought on a strong erection. Also urinating quite a bit. It's noon and I'm still horny. Took my test shot Thursday at noon; 100 mg, IM.
I certainly don't want to overdo the ai. Plus, this coming week, having surgery to repair a large umbilical hernia. Referring to Guy #2, perhaps 1 mg, weekly, would help. I'll also touch base with my urologist in a couple of weeks after I've had time to evaluate that my response wasn't just a fluke.
It’s always fascinating to me when guys take an ai to lower E2 and have a huge spike in libido, when increased E2 is supposed to be the main driver of libido. I wonder if it’s just due to having an improved T:E ratio that favors well in the libido department, or if it’s the fluctuation of hormones that is doing something positive. Obv the latter would be easily disproven if the increased libido stuck around once on the same dose of ai for a while.
But thanks for the update, and with ai’s it’s all about finding the sweetspot. Overdoing them will absolutely make u feel worse than under doing them, or not being on them at all. Just sucks that sweetspot is so different for every guy.
And it would also suck if a certain ai dose did wonders in the libido department, but made a guy feel worse in other areas, like mood and sleep, similar to what ur experiencing atm
Your last comment is on the money. And with my non-response to psych meds for bipolar, my mood is nearly always in flux, even when asleep, which makes it difficult to pin down what might be helping libido/erections or it's being mildly manic, today. But I will give it a few more weeks. The anesthetic gas will probably mess me up for two or three days, too.
I’m telling ya man, the answer for u lies in diet and supplementation. With u having bipolar disorder, until u dial those both in ur gonna always be chasing ur tail. I worked in psych for 5 years, and been a nurse for 10+ years, I would stay far far away from any and all psych meds.
Have u looked into lithium orotate?
I try my best to not push anything on anyone, but I can’t help but let u know that with u having bipolar disorder, ur always gonna be chasing ur tail until u optimize ur diet, supplementation, exercise and sleep.
Sleep is the most elusive and it is the foundation for mood stability, as well as physical well being. Tried lithium orotate several times over the years. Never found it to be helpful. All psych meds produce side effects but nothing beneficial. I'd be on one if it helped. Diet is hard, too. As I wrote months ago my wife is a vegan and if I started eating a heavy meat diet, such as carnivore, she'd have a breakdown. I eat fish, both frozen and canned(salmon, sardines). The stress level is high, too, as my wife's dementia is slowly getting worse. All I can do is keep trying. Thanks.
Oh ya, I remember u telling me about ur wife and her being vegan and her having dementia. Ur definitely between a rock and a hard place. And dementia is extremely difficult. I worked on an Alzheimer’s/ dementia floor for around 4 years, and my grandfather that lived next door to me passed away from it. It’s a horrible disease.
Until ur able to eat primarily meat it’s almost impossible to fix ur issues, unfortunately, so I won’t even try to recommend anything. Be careful with eating too much fish tho, here’s a podcast where a guy poisoned himself very badly eating too much fish. After watching it I personally cut out the canned sardines I was eating 2-3x per week, and now just supplement with very high quality EPA and DHA. I take them in separate supplements so that I can adjust the ratio of each to my liking.
And I have a bunch of tips to improve sleep, that absolutely work, but it doesn’t seem like u have the time, energy, or motivation rn to implement any of them.
And consider urself lucky that none of the psych meds worked for u. They’re all horrible in the long term, and end up causing more issues than they fix, and are just riddled with side effects. Plus, they don’t do anything that u can’t do on ur own through diet, supplementation and life style modifications. Stinks that lithium orotate didn’t do anything for ya.
Charliebizz
Well-Known Member
Any update on your a.i trial ?
I took two doses and then stopped. I know that’s not exactly a legitimate trial, but I decided I would give Xyosted more time in order to determine how I feel without an AI. Haven’t ruled out adding it back in down the road if E2 symptoms drift upward.
I keep coming back to this thread. Now been on 100 mg, IM, Test E for three months. Libido is there most days; sometimes quite strong, sometimes moderate, but present in my mind and body. However, zero improvement in erectile function. Rare nocturnal erections, no morning wood. If my libido is strong and I stimulate myself, I get an impressive, short lived erection. MyTT: 1064. FT: 225. E2(ultrasensitive/Quest): 54. Reintroducing anastrazole. I don't know what dose or if I'll do daily, EOD or weekly.
drpepper68
Member
What’s your prolactin me DHT? High prolactin causes me issue a well as low DHT (when used to use Finasteride)
I wouldn’t jump on anything you don’t need but if you try Anastrozole I would only do .25mg to start. But at 54 I wouldn’t think it’s that but everyone is different.
I wouldn’t jump on anything you don’t need but if you try Anastrozole I would only do .25mg to start. But at 54 I wouldn’t think it’s that but everyone is different.
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