I tried once weekly injections and because my SHBG was mid range it just didn't work well for me. I would inject on Monday AM and felt real good Tuesday, Wednesday, and Thursday. But as the injection wore off I felt worse and worse. Friday I felt just "okay" but Saturday and Sunday I felt like I did before starting TRT.
Once weekly injections work well in two situations. One, if you have high SHBG it is going to give you the best chance at success with TRT. Two, you just don't want to inject more than once a week and you are willing to live with feeling crappy a couple days of the week like I mentioned in the first paragraph.
I now inject E3.5D, Monday AM and Thursday PM. However, I am considering going to an ED protocol.
So for me, I did not feel better on once weekly injections.