Methylene Blue

No, I stopped a while back for a couple of reasons. I was a bit concerned as to the purity. Also concerned about contraindication possibilities with Selegeline.

There are a lot of well-respected people who have very positive things to say about it, so I don't have any reservations as to its possibilities. It's mainly the sourcing issues. This isnt something you would want to take if it isn't medical grade.
What do u think of this product? This is the one I ordered and am taking

What product were u taking?

 
I too have stopped taking it consistently and only take it if I have a cold, which I almost never do. It's worth stepping back and considering the general guideline that it is best to wait about 5 years after a compound/drug is released before making a judgment on it's risk/reward. I think people sometimes just apply that to "drugs" but it could apply to just about anything. In the case of MB, Chris Masterjohn raised some interesting concerns about whether it is really beneficial for a person who is already healthy, and I have heard of clinicians raising concerns that it decreases bifido bacteria and may negatively impact gut bacteria.

Regarding the wait and see guidelines, VIOXX was the poster child for this and we have seen this in real time too with recent things such as GLP-1 agonists. As Dr. Kendrick noted as an example, if a group of people started smoking, it would take about 5 years for the problems to start to be really apparent, and due to the fat-loss affects of nicotine, it could look beneficial early on. I think AmidwesternDoctor on Substack recommends 7 years (who by way is IMO essential reading...the amount and quality of what he puts out is incredible) but the bottom line is that it takes a while for the totality of an intervention to really become clear, and taking some new compound, especially one that is highly impactful, is not a great idea unless someone is faced with absolutely no alternative, which very few of us are.
 
What do u think of this product? This is the one I ordered and am taking

What product were u taking?

I don't recall the brand I used. It's good to use a tested product, that one looks to be as good as any I have seen.
 
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I cannot get this troches (EU) but many of you (US) could get this double quality tested source of methylene blue.
 
What a coincidence - i was reading this thread earlier today. @Guided_by_Voices mentioned Chris Masterjohn a couple of posts above, who i follow and get emails from. And just now, he's sent out a really long email all about methylene blue. I can copy/paste it if anyone's interested, it's long though
 
Just skimmed over what Chris masterjohn said, but seems like he’s not a fan of methylene blue. He says that over time it actually makes ur mitochondria work less efficiently. Which is ironic since it’s promoted as a compound that improves mitochondrial function
 
What was the dose u were taking?
I think it was a 2 oz bottle and I was taking from a half to a full dropper in a full glass of water. And as someone very experienced with various levels of depression, I can tell when something has a particular effect on my mood and the MB put me in a very distinct funk. I wasn't taking any other meds so it was the MB and MB alone that accounted for it and the symptoms ceased when stopped.
 
I think it was a 2 oz bottle and I was taking from a half to a full dropper in a full glass of water. And as someone very experienced with various levels of depression, I can tell when something has a particular effect on my mood and the MB put me in a very distinct funk. I wasn't taking any other meds so it was the MB and MB alone that accounted for it and the symptoms ceased when stopped.
Sounds like ur dose was too high. Definitely the methylene blue tho for sure. Might have been raising ur serotonin levels too much. Ever since SSRI’s became big, everyone thinks the more serotonin the better. Couldn’t be further from the truth. So many negative things occur when u raise serotonin levels too much
 
Sounds like ur dose was too high. Definitely the methylene blue tho for sure. Might have been raising ur serotonin levels too much. Ever since SSRI’s became big, everyone thinks the more serotonin the better. Couldn’t be further from the truth. So many negative things occur when u raise serotonin levels too much

Totally agree with you about serotonin. Years ago, my gp at the time prescribed me an ssri (paroxetine) when i said i was having trouble sleeping due to stress. "You'll feel great too" he told me..... Second worse med i've ever taken (i binned them after a few weeks) - only one worse than that was some years later when a different gp convinced me to try a different ssri, (sertraline) after a major bad event in my life happened. Well it took my mind off the event that's for sure, but only because its effects were do bad i wanted to throw myself off the nearest cliff. And coming off the drug was so bad i had to be prescribed a course of diazepam to get through it. I know serotonin is important, (and that an ssri itself isn't actually serotonin). But i think doctors promoting ssri's as 'happy pills' should be force fed them to see for themselves exactly what the s*** feels like. I read a good theory once about how ssri's, when they do have a positive effect for someone, actually work. It was that they flood the brain with so much serotonin that its receptors eventually become resistant or insensitive to the serotonin, allowing dopamine to be dominant so to speak (something like that). It would explain why things can get worse for the patient when commencing treatment before (if it works for them) getting better. Ssri's and statins - docs just love dishing 'em out for some reason.
 
Totally agree with you about serotonin. Years ago, my gp at the time prescribed me an ssri (paroxetine) when i said i was having trouble sleeping due to stress. "You'll feel great too" he told me..... Second worse med i've ever taken (i binned them after a few weeks) - only one worse than that was some years later when a different gp convinced me to try a different ssri, (sertraline) after a major bad event in my life happened. Well it took my mind off the event that's for sure, but only because its effects were do bad i wanted to throw myself off the nearest cliff. And coming off the drug was so bad i had to be prescribed a course of diazepam to get through it. I know serotonin is important, (and that an ssri itself isn't actually serotonin). But i think doctors promoting ssri's as 'happy pills' should be force fed them to see for themselves exactly what the s*** feels like. I read a good theory once about how ssri's, when they do have a positive effect for someone, actually work. It was that they flood the brain with so much serotonin that its receptors eventually become resistant or insensitive to the serotonin, allowing dopamine to be dominant so to speak (something like that). It would explain why things can get worse for the patient when commencing treatment before (if it works for them) getting better. Ssri's and statins - docs just love dishing 'em out for some reason.
That’s an interesting theory about SSRI’s and dopamine. And it’s funny cuz I was gonna say in my last reply that it’s actually dopamine that people probably want, if they want all the benefits that SSRI’s promise to give. Increasing dopamine will give u a better sense of well being, more energy, more drive, possibly improved sexual function. Basically all the things anyone would want to see improvements in. Increasing serotonin, as far as I know, can inhibit sexual function, and possibly cause a numbing type of mental effect. Which I can see helping people that are very depressed/ suicidal. Feeling emotionally numb, is much better than feeling depressed/ suicidal, I would imagine. When researching what serotonin does, I just don’t see how increasing levels of it would be a good way to treat depression.

I actually tried increasing my serotonin levels when I was in like my 20’s. I bought some precursors, that were supposed to help increase serotonin levels. And I think they did. But I felt horrible. I felt super emotionally numb. Like I wasn’t happy, but I wasn’t sad. I just like didn’t care. It was so weird. I just remember hating it, and stopping the precursors immediately after I started feeling like that. And I’m not saying everyone that increases serotonin levels are gonna feel exactly like I did, but from what I understand about SSRI’s, and increasing serotonin levels, that can be a pretty common occurrence in many people

It is really interesting that so many of these men that end up mass murdering a bunch of people are on SSRI’s. Again, kind of makes sense with the whole emotionally numb thing. It would kind of take an emotionally numb person to be able to do something like that, I would assume.
 
I think it was a 2 oz bottle and I was taking from a half to a full dropper in a full glass of water. And as someone very experienced with various levels of depression, I can tell when something has a particular effect on my mood and the MB put me in a very distinct funk. I wasn't taking any other meds so it was the MB and MB alone that accounted for it and the symptoms ceased when stopped.
4mg starting dose
 

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