KYZATREX (oral testosterone undecanoate) now available in all states across the US

[madman]

Testosterone Update on Oral Products

T. Mike Hsieh, MD, MBA, a professor in the Department of Urology at the University of California San Diego (UCSD) School of Medicine and Director, of the Men's Health Center at UCSD Health provides an update on available oral testosterone treatments, their efficacy, and risks involved and...

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[madman]

Early Access Program for KYZATREX™ to patients across the world

https://www.globenewswire.com/news-release/2023/08/10/2722814/0/en/Marius-Pharmaceuticals-Partners-with-Smartway-to-Design-and-Manage-the-global-Early-Access-Program-for-KYZATREX-testosterone-undecanoate.html RALEIGH, N.C., Aug. 10, 2023 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals (Marius) and...

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[madman]

Oral Testosterone Replacement Therapy

Oral Testosterone Replacement Therapy: What’s Available and What Took so Long? Introduction The field of testosterone replacement therapy (TRT) has witnessed remarkable growth and demand in recent years. While injectable and topical forms remain popular, other types of TRT including oral...

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[madman]

Price Comparison: Marketed product and lowest dosage of other products in same therapeutic class for treatment is an androgen indicated for testosterone replacement therapy inadult males for conditions associated with a deficiency or absence of endogenous testosterone

 

[Systemlord]

What dosage of Kyzatrex compares with Jatenzo at 237 mg?

 

[madman]

What dosage of Kyzatrex compares with Jatenzo at 237 mg?

200 mg.



2 DOSAGE AND ADMINISTRATION

2.1 Confirmation of Hypogonadism

Before Initiation of JATENZO Prior to initiating JATENZO, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these testosterone concentrations are below the normal range.


2.2 Dosing and Dose Adjustment Information

Individualize the dosage of JATENZO based on the patient’s serum testosterone concentration response to the drug. The recommended starting dose is 237 mg taken orally twice daily, once in the morning and once in the evening. Take JATENZO with food.


Dose Adjustment

To ensure proper dose adjustment, measure serum testosterone concentrations 6 hours after the morning dose in plain tubes, clotted at room temperature for 30 minutes prior to centrifugation. Adjust the JATENZO dose based on this serum testosterone measurement as shown in Table 1. Wait seven days after starting treatment or adjusting the dose before checking the serum testosterone concentration. Thereafter, periodically monitor serum testosterone concentrations 6 hours after the morning dose.

Administer the same dose in the morning and evening. The minimum recommended dose is 158 mg twice daily. The maximum recommended dose is 396 mg (two 198 mg capsules) twice daily.

2 DOSAGE AND ADMINISTRATION

2.1 Important Dosage Information

KYZATREX is not substitutable with other oral testosterone undecanoate products.


2.2 Confirmation of Hypogonadism Before Initiation of KYZATREX

Prior to initiating KYZATREX, confirm the diagnosis of hypogonadism by ensuring that serum testosterone concentrations have been measured in the morning on at least two separate days and that these testosterone concentrations are below the normal range.


2.3 Recommended Dosage and Administration

Individualize the dosage of KYZATREX based on the patient’s serum testosterone concentration response to the drug.

The recommended starting dose is 200 mg orally twice daily, once in the morning and once in the evening. Take KYZATREX with food.


Dosage Adjustment

Check serum testosterone concentrations 7 days after starting treatment or after dosage adjustment, 3 to 5 hours after the morning dose. Adjust the KYZATREX dose as necessary as shown in Table 1. Thereafter, periodically monitor serum testosterone concentrations.

The minimum recommended dose is 100 mg once daily in the morning. The maximum recommended dose is 400 mg twice daily. For total daily doses greater than 100 mg, administer the same dose in the morning and evening.

 

[Systemlord]

There’s a urologist who recommends dosing Kyzatrex in the morning and early afternoon (1-2 pm). The reason being, better to keep testosterone higher during the time when we’re active most, rather than when sleeping.

 

[madman]

There’s a urologist who recommends dosing Kyzatrex in the morning and early afternoon (1-2 pm). The reason being, better to keep testosterone higher during the time when we’re active most, rather than when sleeping.

Yes, that would be Dr. Sun.


30:19-30:37

Testosterone: Navigating Options & Implementation in Clinical Practice

Great interview! Very thorough. This video discusses the importance of men’s health and the role of urologists in addressing conditions like testosterone deficiency. Key Takeaways: *Dr. Andrew Sun provides an overview of different testosterone treatment options, including both internal...

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There are a few uros that would recommend this for patients struggling with that amped-up feeling after the evening dose which may interfere with falling asleep in susceptible individuals.

Best to experiment and see what works best for you.

I have been on injections for almost 7 years and the majority of the time I tend to inject late in the evening or right before bed as I have no issue falling/staying asleep.

I can always feel the surge in T 12 hrs later as my libido is more intense and spontaneous erections occur.

This is a given.

 

[Systemlord]

There are a few uros that would recommend this for patients struggling with that amped-up feeling after the evening dose which may interfere with falling asleep in susceptible individuals.

Best to experiment and see what works best for you.

TRT has always helped me sleep better, missing my Jatenzo in the evening messes up my sleep, I wake up feeling something is off, that’s usually when I go to my medicine container and find out that I missed my evening Jatenzo.

So I’m less inclined to dose Jatenzo in the early afternoon. High testosterone helps me sleep better.

My erections are no different at peak than they are at trough.

My erectile quality is strongly linked to my sleep quality and hydration status!

 

[madman]

 

[madman]

“PRIME”, POWERED BY KYZATREX®️ (CIII TESTOSTERONE UNDECANOATE CAPSULES)

https://finance.yahoo.com/news/mangoceuticals-introduce-prime-powered-kyzatrex-123000672.html The Dallas Based, Direct-to-Consumer Telemedicine Company Secures Marketing Agreement with Marius Pharmaceuticals Bringing KYZATREX to the Telehealth Market as ‘Prime’ by MangoRx Dallas, Texas &...

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[Nelson Vergel]

Effects of the oral TU Kyzatrex™ on ambulatory blood pressure in HG men

Abstract Testosterone replacement therapies have been shown to increase blood pressure (BP) in hypogonadal men. We studied the effects of a new formulation of testosterone undecanoate (Kyzatrex™) on ambulatory blood pressure (ABP) and heart rate, in 155 men with hypogonadism (mean age, 50.5...

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[Nelson Vergel]

Kyzatrex - Oral testosterone replacement therapy

Kyzatrex - Oral testosterone replacement therapy (2022) Adam Ali Asghar *, Mahnoor Rehan Hashmi, Rushaan Ahmed, Yumna Khabir Male hypogonadism, characterized by the body’s inability to secrete sufficient amounts of testosterone [1], affects approximately 40% of men over the age of 45 globally...

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[Nelson Vergel]

A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product - PubMed

URL: https://clinicaltrials.gov/ unique identifier NCT04467697, conducted under NCT03198728. Post-completion, clinicaltrials.gov requested creation of the separate NCT04467697 identifier. All subjects were recruited under NCT03198728.

pubmed.ncbi.nlm.nih.gov

 

[SSHSSA74]

Would like to try this Kyzatrex.

 

[Ravenouz]

In my experience, oral testosterone produces extremely consistent results.

More consistent than injections. No need to change the dosage every so often. My hormone levels are the same now as they were two years ago.

Do you currently take these? I despise the injections and have a whole bunch of vials that are going to goto waste....are these just as effective? I have low free testosterone. Im totally impotent, cant get an erection, have zero libido.

 

[Systemlord]

Do you currently take these?

I'm on Jatenzo @237 mg twice daily. I have libido and erections, not so on injections after a couple of weeks. The rapid and frequent spikes in hormones I believe is the reason for optimal response.

When on injections, I don't feel the anabolic effects even with similar hormone levels.

The other day I tested testosterone at 4 pm, 3 hours past my midpoint. I was still in the 400 range, having spent the morning and mid afternoon with testosterone at the top end of the ranges.

Jatenzo is the only formulation of TRT that has worked for me!

 

[Ravenouz]

I'm on Jatenzo @237 mg twice daily. I have libido and erections, not so on injections after a couple of weeks. The rapid and frequent spikes in hormones I believe is the reason for optimal response.

When on injections, I don't feel the anabolic effects even with similar hormone levels.

The other day I tested testosterone at 4 pm, 3 hours past my midpoint. I was still in the 400 range, having spent the morning and mid afternoon with testosterone at the top end of the ranges.

Jatenzo is the only formulation of TRT that has worked for me!

I wish you told me this before,I know its not your duty to its just that everyone on this forum is telling me to get this vial and that vial, take this much injection of this, and this much of that, I did all of that and had zero erections from it...a pill is so much more simple...and it seems for you its very effective...I am going to see if I can call my doctor and get these ASAP...is there another sort of pill you have to take to counter act the effects of this? My dick does not work so i really have nothing left to loose, but 1 thing I dont want is to grow tits. I see a bunch of ppl on this forum complaining about that, to grow tits and not have a working penis would be a new everlasting nightmare. I already have to deal with 1 for the rest of my life, i dont want tits on top of it.

 

[Systemlord]

I wish you told me this before,I know its not your duty to its just that everyone on this forum is telling me to get this vial and that vial, take this much injection of this, and this much of that, I did all of that and had zero erections from it...a pill is so much more simple..

I’m pretty sure I did tell you about it and even if I didn’t, the forum is full of threads about the subject of oral testosterone.

I believe the rapid spike in hormones overcomes my insulin resistance and any other metabolic issues whereas the injections doesn’t.

 

[Ravenouz]

I’m pretty sure I did tell you about it and even if I didn’t, the forum is full of threads about the subject of oral testosterone.

I believe the rapid spike in hormones overcomes my insulin resistance and any other metabolic issues whereas the injections doesn’t.

This may be my issue also, it just seems that most ppl are hell bent on the injections, no one recommended the pills to me, not even the doctors. They offerered me the testosterone that you leave under your skin for 4 weeks...son of a b***** if they said here take this pill it would of been 1000 easier to consider. I ended up not doing the under the skin tablet and went for the injections.

Did you get any nasty side effects by the way? I am looking at all the warnings and one of them says increase risk of death. Do you experience any side effects?