KYZATREX (oral testosterone undecanoate) now available in all states across the US

KYZATREX™ (testosterone undecanoate capsules)

The Power of Hormonal Balance | Restore your T- levels with Two KYZATREX capsules a day. | Discover KYZATREX Rediscover CONFIDENCE | A solution sans needles, gels, or creams

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KYZATREX (testosterone undecanoate) is an oral testosterone replacement therapy specifically designed for adult males with conditions associated with a deficiency or absence of endogenous testosterone, such as primary hypogonadism and hypogonadotropic hypogonadism 1112. Here is detailed information regarding its dosage, usage, side effects, price, and efficacy:

Dosage​

KYZATREX is available in capsule form in three dosage strengths: 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg taken orally twice daily, once in the morning and once in the evening, with food to enhance absorption 2412. Dosage adjustments are made based on serum testosterone levels measured 3 to 5 hours after the morning dose, at least 7 days after starting treatment or following a dose adjustment 45.

Usage​

KYZATREX capsules should be taken with food. The therapy is initiated only after confirming hypogonadism through appropriate tests that show serum testosterone concentrations below the normal range. It is important to monitor blood pressure regularly due to the risk of hypertension associated with its use 1012.

Side Effects​

Common side effects include increased blood pressure, which may necessitate the use of antihypertensive medications. Other potential side effects are acne, pain at the injection site, increased red blood cell count, and mood changes. Serious side effects may include major adverse cardiovascular events such as heart attacks and strokes11517.

Price​

The price of KYZATREX can vary depending on the pharmacy, insurance coverage, and dosage. It is advisable to consult with a healthcare provider or pharmacist for the most accurate pricing information.

Efficacy​

KYZATREX has shown high efficacy in clinical trials, with up to 96% of patients achieving normal testosterone levels within 90 days of treatment. The therapy effectively manages symptoms associated with testosterone deficiency, such as fatigue, low libido, and muscle loss 367. The formulation is designed to be absorbed through the lymphatic system, reducing the risk of liver toxicity commonly associated with oral testosterone treatments 18.

Additional Considerations​

KYZATREX carries a boxed warning regarding the potential for blood pressure increases and the associated risk of cardiovascular events. It is classified as a Schedule III controlled substance due to potential for misuse and abuse 1017. It is not indicated for use in women, particularly those who are pregnant, and it is not approved for treating low testosterone due to aging19.In summary, KYZATREX offers a significant advancement in the treatment of male hypogonadism, providing a convenient oral formulation that avoids the complications of other testosterone delivery methods like injections and gels. However, careful monitoring for side effects, particularly hypertension, is crucial.

 

Kyzatrex is not a 17-alpha-alkyl androgen and is not known to cause hepatic adverse effects.

Kyzatrex, as an oral testosterone replacement therapy (TRT), offers a distinct approach compared to other TRT options like transdermal patches, intramuscular injections, subcutaneous pellets, and nasal gels. Here's a comparison based on various aspects:

Administration and Absorption​

Kyzatrex is a soft gel capsule that you take by mouth. It contains testosterone undecanoate that has been dissolved in a mix of lipids and other solubilizers so that it can be quickly absorbed by the bloodstream while you eat. This formulation allows systemic delivery of oral testosterone undecanoate via the intestinal lymphatic system, bypassing the liver completely, which is a significant advantage over traditional oral testosterone therapies that could cause liver toxicity 24. Other TRTs, such as transdermal patches, intramuscular injections, and nasal gels, have their own administration routes, which may not be as convenient for some patients and can cause application site reactions 2.

Efficacy​

Clinical studies have shown that oral TRT, including Kyzatrex, is effective in maintaining serum testosterone levels within the normal range. Kyzatrex, in particular, has demonstrated a high efficacy rate, with up to 96% of patients achieving normal testosterone levels within 90 days of treatment. This is comparable to the efficacy rates of other TRT options3. However, some research indicates that TRT injections might be more effective at increasing muscle strength compared to oral testosterone3.

Side Effects​

Kyzatrex and other oral TRTs have been associated with increased blood pressure, which may lead to heart attack or stroke, among other adverse effects like increased red blood cell count 2. While injectable and transdermal TRTs also share some of these risks, the impact on blood pressure is a notable concern with oral testosterone undecanoate formulations 67. However, Kyzatrex has shown a lower risk of hypertension compared to other oral TRTs like Tlando and Jatenzo3.

Convenience and Patient Preference​

Patients typically prefer oral TRTs, such as Kyzatrex, as an easy method of administration over injections or topical applications, which can be uncomfortable or result in transference problems. 4. The need to take Kyzatrex with food for effective absorption might be a consideration for some patients 4.

Cost and Insurance Coverage​

The cost and insurance coverage for Kyzatrex compared to other TRTs can vary. While most insurance plans do not cover oral testosterone as a first-line treatment, there may be options to make oral medication more affordable for patients who cannot use other forms of TRT or have experienced side effects 4.

 

A pill that could outsell Viagra: New testosterone Rx drug

https://www.americanbazaaronline.com/2022/10/11/testosterone-drug-kyzatrex-hits-market-451261/ Kyzatrex could be a potential blockbuster to treat testosterone deficiency, a severely undertreated disease. Testosterone has been historically perceived as a lifestyle issue for men who want to...

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If prescribed, your monthly treatment plan ($149) includes the following:

*a monthly supply of your FDA-approved oral testosterone prescription

 

KYZATREX®

Novel Oral T Formulation Improves Male Well Being Without Compromising IPSS

Abstract Introduction: Male hypogonadism results from insufficient secretion of testosterone (T) and is characterized by low serum T concentrations. Common symptoms of hypogonadism include decreased libido, impotence, weakness, low energy, depression and/or loss of motivation, memory and...

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Effects of the oral TU Kyzatrex™ on ambulatory blood pressure in HG men

Abstract Testosterone replacement therapies have been shown to increase blood pressure (BP) in hypogonadal men. We studied the effects of a new formulation of testosterone undecanoate (Kyzatrex™) on ambulatory blood pressure (ABP) and heart rate, in 155 men with hypogonadism (mean age, 50.5...

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Novel oral testosterone replacement therapy headed to FDA

https://www.mdedge.com/familymedicine/article/235184/mens-health/novel-oral-testosterone-replacement-therapy-headed-fda?sso=true Marius Pharmaceuticals has submitted a new drug application (NDA) to the Food and Drug Administration for Kyzatrex, an oral testosterone replacement therapy (TRT)...

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FDA Approves Oral Testosterone Replacement Therapy Kyzatrex

Another oral testosterone undecanoate. https://www.empr.com/home/news/fda-approves-oral-testosterone-replacement-therapy-kyzatrex/

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Andriol, which is oral testosterone undecanoate, has been available in Australia for a long time, more than a couple of decades. It was never very popular here. I tried it many years ago and did not feel very much from it at all unfortunately.

 

Kyzatrex DTPt Program

kyzenroll.eaglepharmacy.com

Get Started | Why Kyzatrex | Safe, Easy, Up to 96% Effective

See how KYZATREX® helps restore normal testosterone levels, including information on clinical studies and side effects - see PI, including Boxed Warning

www.kyzatrex.com

 

At $150/month, I don't expect many orders when there are way cheaper modalities.

 

At $150/month, I don't expect many orders when there are way cheaper modalities.

Most definitely but keep in mind that there are men seeking out other options as they have no interest in using transdermal (gels/creams) let alone poking themselves with needles regardless of the cost.

If we are talking Big Pharma $150/month for Kyzatrex is a steal when compared to Tlando let alone Jatenzo LOL!

Even than as I have stated before most will always aim for injections not only because they are the cheapest/most effective route but more importantly everyone and their brother is aiming for those absurdly high trough TT/FT levels!

Stuck on that more T is better mentality LMFAO!

All bout dem gainz bruh!

F**K it if I am struggling with sides can here dem weights calling me.

 

In my experience, oral testosterone produces extremely consistent results.

More consistent than injections. No need to change the dosage every so often. My hormone levels are the same now as they were two years ago.

 

Is there anything special about this formulation? Is it just Test Undecanoate? I surprised this isn't more widely available from compounding pharmacies and/or UGLs.

 

At $150/month, I don't expect many orders when there are way cheaper modalities.

Most people going to online TRT shops are paying at least $100 a month. This is really not that much more.

 

Most people that actually quality for TRT are getting it through their primary doctor and insurance for free. The ones that don't need TRT but want to "optimize" themselves are mostly getting injectable testosterone from sites for probably $30/month, and the blood tests through their doctors are covered by insurance.

So very few that know what they are doing are going to jump on the $150/month bandwagon, especially in that economy that is going to get worse.

 

How much daily fluctuation are we actually talking about with these, does the undecanoate just build up in the system and keep levels super stable? Did they release any PK charts for this or jatenzo?

 

How much daily fluctuation are we actually talking about with these, does the undecanoate just build up in the system and keep levels super stable? Did they release any PK charts for this or jatenzo?

SAGE Journals: Your gateway to world-class research journals

Subscription and open access journals from SAGE Publishing, the world's leading independent academic publisher.

journals.sagepub.com

 

Oral Testosterone: The New Frontier of TRT

https://www.prostatehealthpodcast.com/84-oral-testosterone-the-new-frontier-of-testosterone-replacement-therapy-with-wayne-kuang-md/#testosterone We are excited to partner with Marius Pharmaceuticals for today’s podcast and have Dr. Wayne Kuang joining us as our featured guest! Until...

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Oral TRT Products: Jatenzo, Tlando, Kyzatrex, & DiTest

Testosterone Replacement Therapy: A Narrative Review with a Focus on New Oral Formulations (2022) Salman Z Bhat and Adrian S Dobs Male hypogonadism affects 10–30% of the male population and is often under-recognized and under-treated. Different replacement formulations exist, each with...

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Novel administration methods for treating low testosterone

Novel methods for the treatment of low testosterone (2023) Julius Fink & Shigeo Horie Abstract Introduction Testosterone replacement therapy is a promising and growing field in modern healthcare. Several novel testosterone preparations aiming at providing an efficient drug without side...

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A pill that could outsell Viagra: New testosterone Rx drug

https://www.americanbazaaronline.com/2022/10/11/testosterone-drug-kyzatrex-hits-market-451261/ Kyzatrex could be a potential blockbuster to treat testosterone deficiency, a severely undertreated disease. Testosterone has been historically perceived as a lifestyle issue for men who want to...

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My Experience On Jatenzo (Oral TRT) Log

Please post your lab results. Thank you for sharing. So I guess it’s like the creams and a blood test is required 4-6 hours after. Good to know. Honestly I think these short half life preparations are the best for trt long term. Jmo I kinda agree with this sentiment (short half lives). But, I...

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FDA Approves Oral Testosterone Replacement Therapy Kyzatrex

Another oral testosterone undecanoate. https://www.empr.com/home/news/fda-approves-oral-testosterone-replacement-therapy-kyzatrex/

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Official Natesto Thread

Whole thesis worth a browse but chapter 3 is pertinent to this thread plus some tips on proper administration in the discussion. Chapter 1 a nice review if you want more background. Long story short, you probably aren't beating a WADA test on Natesto unless you know what you are doing (purely...

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My Experience On Jatenzo (Oral TRT) Log

Was ur energy at the same level as before donating blood, or was it higher than before? The energy levels are the same regardless of hematocrit and hemoglobin levels, however erections are better after the phlebotomy. This is the second time my erections have gotten better on day two after a...

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Alternating Dosage Every other day on Daily Dosing

Hi everyone, Just a theory I've been having. I started doing daily dosing recently and it's probably the best I've felt since staring TRT. I'm a low SHBG by the way (around 20). But my main issue is insomnia and I'm curious if this is caused by having a steady state of high test levels. So...

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Better Libido/Sexual Function with different esters?

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TRT only "works" when it's clearing the system

Similar to those who say they only feel the honeymoon phase for a little bit during new protocol, I only feel the effects of TRT (libido) for 1-2 days, after week 4 of my last injection, when the T has mostly cleared your system. Reverse honeymoon phase. Other than that, I feel nothing from T no...

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My Experience On Jatenzo (Oral TRT) Log

I wanted to start a thread detailing my personal experience with Jatenzo (oral TRT) which is remarkable in how quickly it has shown results when compared with injections. The first week on Jatenzo was very pleasant unlike my experience after dosing changes on injections, all with minimal swings...

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SAGE Journals: Your gateway to world-class research journals

Subscription and open access journals from SAGE Publishing, the world's leading independent academic publisher.

journals.sagepub.com

View attachment 35067

FDA Approves Oral Testosterone Replacement Therapy Kyzatrex

Another oral testosterone undecanoate. https://www.empr.com/home/news/fda-approves-oral-testosterone-replacement-therapy-kyzatrex/

www.excelmale.com

 

SAGE Journals: Your gateway to world-class research journals

Subscription and open access journals from SAGE Publishing, the world's leading independent academic publisher.

journals.sagepub.com

View attachment 35067

Thanks for that, are you satisfied with estradiol levels, i sure wish one day it will be available in Europe.

 

Thanks for that, are you satisfied with estradiol levels, i sure wish one day it will be available in Europe.

I don’t know what my estrogen levels are, I’ve never tested them on Jatenzo.

 

i sure wish one day it will be available in Europe.

It’s only a matter of time.

 

It’s only a matter of time.

Maybe so, but they had panteston 40mg capsules, same as andriol, not anymore, it was pretty expensive as you had to swallow a lot of them. I wish they still had it, i would have liked to try low dose undecanoate injections combined with 40-80mg capsules twice daily.