I remember someone posting on a different forum (can’t find the link now) of increased E2 levels on daily dosing vs. breaking up the same dose into 2-3x/week with T Enanthate. Aromatase activity seems to be higher when the peak and trough in T is eliminated from high-frequency dosing. I also see that SHBG is lower when injection frequency is lower, which is a good thing.
Now, the peaks and troughs of e.g. a twice a week or e5d (every half-life of enanthate) would also allow receptors some time off and thus upregulate - which is how all receptors in the body work.
If you constantly bombard a hormone or neurotransmitter receptor with an agonist, they will downregulate to compensate. Same thing with e.g. stimulants, if you keep chronically high levels they will stop working (clenbuterol vs ephedrine is a good example, the former having a 24hr half-life).
Could it be that some variation in levels is better since it imitates physiological pulsatility and maintains androgen receptor sensitivity better?
I have found that taking 100mg of Testogel (10% absorption) 2 days in a row with a 50mg subQ TE injection on the first day, followed by 3 days off (so injecting e5d) seems to make me both retain less water and have better libido vs. daily Testogel or even daily subQ at equivalent dosages - so fluctuating levels subjectively feel better than steady levels and my E2 levels are perfect now (I used to need Aromasin to manage it before).
I see some claiming to subjectively feel better on daily or eod dosing, and since I can’t find any studies comparing e.g. weekly injection frequency vs. daily or every-other-day injections it would be very interesting to get a discussion going on both the theoretical aspect of it as well as personal experiences and blood tests (T:E2 ratios, SHBG etc).
Now, the peaks and troughs of e.g. a twice a week or e5d (every half-life of enanthate) would also allow receptors some time off and thus upregulate - which is how all receptors in the body work.
If you constantly bombard a hormone or neurotransmitter receptor with an agonist, they will downregulate to compensate. Same thing with e.g. stimulants, if you keep chronically high levels they will stop working (clenbuterol vs ephedrine is a good example, the former having a 24hr half-life).
Could it be that some variation in levels is better since it imitates physiological pulsatility and maintains androgen receptor sensitivity better?
I have found that taking 100mg of Testogel (10% absorption) 2 days in a row with a 50mg subQ TE injection on the first day, followed by 3 days off (so injecting e5d) seems to make me both retain less water and have better libido vs. daily Testogel or even daily subQ at equivalent dosages - so fluctuating levels subjectively feel better than steady levels and my E2 levels are perfect now (I used to need Aromasin to manage it before).
I see some claiming to subjectively feel better on daily or eod dosing, and since I can’t find any studies comparing e.g. weekly injection frequency vs. daily or every-other-day injections it would be very interesting to get a discussion going on both the theoretical aspect of it as well as personal experiences and blood tests (T:E2 ratios, SHBG etc).
