Increasing LH on trt

[bixt]

This certainly gives some credence to why EOD creams or prop works well by those who swear by it. A doc who goes by @highpull over at T nation has a few patients (a minority) who swear prop twice a week is the best for them. Logically, it doesn't make sense as we are all brainwashed into thinking "stable levels" are the best and you will feel like shit when you go below a certain level. However, in the context of the above, we may now have some explanation as to why what people feel does not always correlate with their blood (or supposed blood) levels.

Maybe this is the answer to why the guy on the every 3 week injection frequency has a sky high libido (and there's a LOT of them out there, who don't bother to post, because they have no complaints. Their docs just followed the Pfizer leaflet and all is dandy).

 

[Dr.V.P.C.]

Highly interesting stuff Dr!

Have you had any experience with for example with low dose Propionate EOD or E3D + a SERM, being able to raise LH?

We don´t have pharma grade test prop here in Brazil , so because of legal reasons i have never tried.

 

[TLR]

This certainly gives some credence to why EOD creams or prop works well by those who swear by it. A doc who goes by @highpull over at T nation has a few patients (a minority) who swear prop twice a week is the best for them. Logically, it doesn't make sense as we are all brainwashed into thinking "stable levels" are the best and you will feel like shit when you go below a certain level. However, in the context of the above, we may now have some explanation as to why what people feel does not always correlate with their blood (or supposed blood) levels.

Maybe this is the answer to why the guy on the every 3 week injection frequency has a sky high libido (and there's a LOT of them out there, who don't bother to post, because they have no complaints. Their docs just followed the Pfizer leaflet and all is dandy).

I’m smelling what you’re stepping in….I’ve often myself wondered how it was “optimal” for EVERYONE to have stable levels all of the time, given the individual variations between individuals….and every where you look nowadays it seems like settled science “the more frequent the better”. I agree that it looks better on paper, but I know several guys on the standard 100 mg once a week that have no complaints…..

 

[TLR]

It certainly would lead to big peaks and troughs, just like EOD propionate would. As Dr VPC said above though, the effects of the hormones on symptoms, well-being, etc doesn't perfectly track blood levels. Think about how long it takes some guys that quit cold turkey to start feeling withdrawal.

On the one occasion I tried a Clomid / HCG “restart,” I was instructed to wait 14 days after my last dose to start the protocol, and I SWEAR I felt better than I could remember in a long time the last few days before starting, with insane sexual desire…..hmmm…

 

[TLR]

Yes it's possible
Change to transdermal EOD
Put some Clomid
Will recover in some months

Not asking you to “dispense medical advice,” but what would a protocol look like doing this? I get the transdermal EOD dosing, but how much Clomid and when? Daily, EOD? And youve actually seen an LH response while giving exogenous testosterone? I’m not trying to be a douchebag, I’m actually highly interested in what you’re saying. I’ve just always been led to believe exogenous test in any decent dose is going to keep LH pushed down…

 

[Soalian]

Yes.

Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene

TL;DR: Over a period of seven weeks, treatment with GnRH and enclomiphene raised LH and FSH from around 0.1 mIU/mL to about 1.0 mIU/mL, even though TRT and hCG dosing were continued. Subjective results have been encouraging. I had written previously on the subject of GnRH suppression on TRT...

www.excelmale.com

You do have a decent chance of getting some LH production. Subjective results are more variable, perhaps depending on the effects enclomiphene has on estrogenic activity and whether this is good or bad for the individual. In the long run I'd aim for the lowest dose that gives decent results. In the short run the relatively high dose of 25 mg/day might speed up the restart.

If you're saying those are 500 mcg troches of gonadorelin then ideally they would be split in a lot of pieces and used a few time a day. I only need 20 mcg per injected dose to see results. How efficient is troche absorption? 50%? If so this would say that 50 mcg doses might be adequate if there are enough of them. The Royal Medical Center results suggest that infrequent large doses can still work. But then your LH pulses are also infrequent, and it's not clear if there are subjective benefits from this.

where do you stand nowadays on the LH issue on TRT, regarding the suppression of brain LH receptor activation, possibly leading to missing out on putative benefits from neurological effects from having brain LH (or LHR analogs such as HCG) ?

It's still unclear to me whether or not brain LHR activation has important neurological implications on the whole.

Thank you.