Increasing doses of Tadalafil

[Ribeye]

In my quest to conquer ED, I have tried and reported here on my experience with Vyleesi branded, PT 141 (EM power), Tri Mix, Quad Mix, Botox, PRP injections (P Shot), Shockwave ( a real clinic quality system given by an experienced physician). One of the benefits of being treated by an experienced, well trained doc for ED is their knowledge of the meds, and how and when and where they can push the dosing for better benefits. She started me on 5 mg once a day of tadalafil. At her suggestion, the dose increased to 10 mg a day. About 6 months or so ago, we increased the dose to 15 mg, because I kept seeing benefit, with increasing doses. Each increase in dose saw the same side effects come back each time. For me, slight headache, and nasal congestion, and a little flushing. However, after each dose, I saw an increase in ease to get erections, easier ability to keep an erection and better sensitivity. And, after a relatively short time, the side effects dissipated. Recently we increased the dose yet again, to 20 mg per day. Thats a high dose of tadalafil. However, the jump in benefit this time was very significant. Yes, I did see the same side effects come back. Nasal congestion, headache, predominately. But it's now been about a week, and the side effects are largely gone. No more heachaches, nasal congestion is taking less and less time to resolve on its own. Now it comes on when the dose is probably absorbed and at full effect, but only lasts about a half hour or less. The biggest takeaway on effectiveness, has been a very significant increase in ability to get erections and ease in keeping them. I have also seen a very nice increase again in sensitivity. The takeaway here, is once you are acclimated to a medication like this, if you saw improvement but are not where you want/need to be, it is worth the conversation with your doc about increasing the dose. I was concerned about the high dose, however, she reminded me the dosing for pulmonary hypertension (tadalafil is approved and effective for treating pulmonary hypertension) STARTS at 20mg and goes up to 40 mg. So we know it can be taken safely at these doses. It is a relatively inexpensive option for those who have ED issues and worth investigating going up in dose if you are not where you want to be. The KEY it seems for me, was to gradually increase the dose.

 

[JmarkH]

I typically take 5mg in the morning and 5mg in the evening. I have difficulty keeping erections and use the penis rings, which help. I may try the increased dosage also.
As a side note, I also usually take nitric oxide with beetroot at the same time as the tadalafil.

 

[Fernando Almaguer]

I typically take 5mg in the morning and 5mg in the evening. I have difficulty keeping erections and use the penis rings, which help. I may try the increased dosage also.
As a side note, I also usually take nitric oxide with beetroot at the same time as the tadalafil.

how old are you if you don't mind me asking?

 

[JmarkH]

how old are you if you don't mind me asking?

65. My protocol is 50-56mg TC EOD and HCG 500iu every third day.

 

[Golfboy307]

In the last few months, I nudged my daily dose from 5mg to around 7mg which resulted in a large noticeable difference. I feel like the key as we get older is to maintain the quality of our arterial lining (the best we can) so these drugs don't lose effectiveness. That is my goal at least.

 

[Systemlord]

The takeaway here, is once you are acclimated to a medication like this, if you saw improvement but are not where you want/need to be, it is worth the conversation with your doc about increasing the dose.

Increasing the dose of Cialis works fine so long as it doesn’t lower your estrogen too much. This is not guaranteed to happen to everyone.

My estrogen got knocked down to 18 pg/mL on 2.5 mg with medium body fat percentage and a 592 ng/dL midpoint level and 1000+ ng/dL peak level.

Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study - PubMed

Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen-estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil...

pubmed.ncbi.nlm.nih.gov

 

[Fernando Almaguer]

65. My protocol is 50-56mg TC EOD and HCG 500iu every third day.

so you are totaling over 200 mg per week with test, correct?

 

[Fernando Almaguer]

Increasing the dose of Cialis works fine so long as it doesn’t lower your estrogen too much. This is not guaranteed to happen to everyone.

My estrogen got knocked down to 18 pg/mL on 2.5 mg with medium body fat percentage and a 592 ng/dL midpoint level and 1000+ ng/dL peak level.

Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study - PubMed

Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen-estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil...

pubmed.ncbi.nlm.nih.gov

What negatives did you notice from that, still getting erections with the medication?

 

[JmarkH]

so you are totaling over 200 mg per week with test, correct?

Yes, there about. I'm feeling well and my Ft is 29.8 and Estradiol 40.8. That was at the 50mg EOD.