Dr Justin Saya MD
Moderator
Dr. Crisler states this in his book and I find him credible. Of course YMMV and only labs will tell if this is the case for you.
What he really means is 80mg SPLIT UP during the week (like 40mg BIW...as is common with subq) is often equivalent (with regards to area under curve) to 100mg once weekly (i.e. old school IM regimen).
As Zooka15 accurately quoted me above " I think Dr. Saya pointed it out one time, that is not the subq method that is lowering or evening out the e2. Rather when people do subq they are doing more frequent smaller injections."
This same holds true with smaller, more frequent injections whether it be IM (deep or shallow) or subq.