Before I went to injections, I was in pellet therapy with no HCG for about a year. Two main symptoms was atrophy of my testicles and lack of ejacultion volume. Both were corrected with adding HCG. Other than that I also get no other feel that it does anything else for me except raise E2 slightly. I also, like VC, shoot 250iu e3.5d and that seems to be the right amount for me to keep the boys full and volume normal to me.