Huge increase in libido with DIM

[Gman86]

So a few weeks ago, I started on Raloxifene 60mg / ed for my teen gyno which I’m planning to have removed this year. What is interesting is that it seems that the suppression or effect of the SERM on the gyno tissue is helping my overall E2 balance symptom wise. I’m going to do bloods next week to see what’s what.

I’ve seen various studies, mostly in females that state there is more active local aromatisation in breast tissue and in the adipose around it so I theorise that this perhaps is the reason why I needed to go on TRT in the first place (due to the negative feedback loop with LH) and why I have a hypersensitivity to exogenous Testosterone. Particularly long esters.
To put it simply, I think gyno is my problem in that it is actively aromatising more than regular tissue. Not low SHBG.

Hope this info is useful to anyone with similar physiology.

Very interesting hypothesis. Really appreciate the critical thinking skills u clearly have. U could definitely be onto something

 

[Marcuswalliby]

I started taking DIM (2 capsules a day - DIM plus from Nature’s way) and my libido went through the roof (it was already good before starting DIM). So i stopped and resumed a few times to see if it was the DIM responsible for the boost in libido and it seems like it is.
So if you have your lab work looking great but no libido maybe something to try.

Seems to have that effect but in my case my gf just gets worn out and so do I ,I think it would be better to just have the opposite and get it over with but she wouldn't like it .

 

[Marcuswalliby]

Yeah that is the only one I've tried. I need to try some others. I put the DIM plus on my list.

They are such a good company ,they heard me complain and contacted me about giving me a refund .Still I think most of these brands that are legit work .I don't think one brand stands out from the rest .

 

[grimcontango]

Hey all,

Just wanted to update on my case. So things haven’t been as consistent as I’d like, it seems there’s quite some variability in the absorption of DIM and its effect.

The only temporal relief I get is by using Arimidex although as is often the case, the dosing is very hard to manage even in the most fractionated of amounts and Arimidex affects my lipids quite significantly.

Having had recent bloodwork on trough showing high e2 (I feel good when that value is around 100) on just 75-100mg of Testosterone a week and trawling through a myriad of studies, mostly in relation to female breast tissue/breast cancer, myself and the various doctors I consult with can only surmise that gyno or some forms of it is indeed an intracrine organ in that it can produce Estrogen by itself and/or aromatise (excessively in my case). There aren’t many studies on this, but here’s an example Estrogens in the breast tissue: a systematic review

I think my gyno is the original cause of my low T in my early 30s (I’m now 39) - high e2 / prolactin in turn knocking out my hpta and causing a feedback loop. So perhaps when the gland reaches a certain size/output it can cause this issue.

I’m scheduled to have my gyno removed on the 25th of June. So will report back on how this changes my hormone profile in the coming months but I hope my findings are useful for anyone out there with teenage gyno (of a sizeable amount). The surgeon is actually a gyno specialist so I’m exploring on how we can make use of all the data I’ve collected as I think there’s some clinical significance in continuing research on this as it can be prevented during the teenage years.

Although I’m more of a lurker, I would like to thank everyone on the forum and Nelson for all the content that has helped me troubleshoot things over the years.

 

[t_spacemonkey]

i know this is an old thread, but i stopped using DIM due to strong DHT suppresion

Diindolylmethane (DIM) is a plant-derived compound that can inhibit the biological effects of dihydrotestosterone (DHT) in the body. DIM works by preventing DHT from binding to androgen receptors, which causes the body to act as if DHT levels are lower than they actually are. This can be effective for treating hormonal acne, as DHT stimulates oil glands to secrete oil and acne patients are more sensitive to its effects. When taking DIM for acne, skin may start clearing up in 3–30 days

 

[Vince]

DIM suppresses cell proliferation of LNCaP cells and inhibits dihydrotestosterone (DHT) stimulation of DNA synthesis. These activities were not produced in androgen-independent PC-3 cells.

PubMed › ...

Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in ...​

 

[Seagal]

i know this is an old thread, but i stopped using DIM due to strong DHT suppresion

Diindolylmethane (DIM) is a plant-derived compound that can inhibit the biological effects of dihydrotestosterone (DHT) in the body. DIM works by preventing DHT from binding to androgen receptors, which causes the body to act as if DHT levels are lower than they actually are. This can be effective for treating hormonal acne, as DHT stimulates oil glands to secrete oil and acne patients are more sensitive to its effects. When taking DIM for acne, skin may start clearing up in 3–30 days

Had no idea. Only read about in the context of estrogen clearance. Wonder if it has any effect on hair loss....

 

[Vince]

The Plant Derived 3-3′-Diindolylmethane (DIM) Behaves as CB2 Receptor Agonist in Prostate Cancer Cellular Models

3-3′-Diindolylmethane (DIM) is a biologically active dimer derived from the endogenous conversion of indole-3-carbinol (I3C), a naturally occurring glucosinolate found in many cruciferous vegetables (i.e., Brassicaceae). DIM was the first pure ...

www.ncbi.nlm.nih.gov

 

[Nelson Vergel]

So without HCG your libido tanks? Are your erections not as strong as well, or does your libido just take a dive without the HCG?

Without hCG (plus TRT), I have hardly any desire to "hunt" for sex.

Remember, I am a 65-year-old man who has used TRT for over 35 years and who is also taking antiretrovirals and other medications while living with HIV for 40 years. I am not a "typical" case. That is why I have always been obsessed with any new developments, not only to remain sexually active but also to look good and feel half-decent while aging with this inflammatory disease.

 

[Gman86]

Without hCG (plus TRT), I have hardly any desire to "hunt" for sex.

Remember, I am a 65-year-old man who has used TRT for over 35 years and who is also taking antiretrovirals and other medications while living with HIV for 40 years. I am not a "typical" case. That is why I have always been obsessed with any new developments, not only to remain sexually active but also to look good and feel half-decent while aging with this inflammatory disease.

And u take 1000iu’s/ week, correct? How many injections of HCG do u do per week?

 

[t_spacemonkey]

Without hCG (plus TRT), I have hardly any desire to "hunt" for sex.

Remember, I am a 65-year-old man who has used TRT for over 35 years and who is also taking antiretrovirals and other medications while living with HIV for 40 years. I am not a "typical" case. That is why I have always been obsessed with any new developments, not only to remain sexually active but also to look good and feel half-decent while aging with this inflammatory disease.

i can only confirm that without HCG my sex drive is 'blunt'. i get it done but it really feels meh. HCG makes all the difference in the world. i personally experimented with various doses (due to cheap indian hcg) and 3x1000IU is a sweet spot for me.

 

[Gman86]

i can only confirm that without HCG my sex drive is 'blunt'. i get it done but it really feels meh. HCG makes all the difference in the world. i personally experimented with various doses (due to cheap indian hcg) and 3x1000IU is a sweet spot for me.

So 3000iu’s/ week total?

 

[grimcontango]

Hello everyone

I’m 5 days post op from having my gyno removed. If anyone wants to see, I can post the gory photos of the glands that were excised. I haven’t seen my chest yet and will be seeing it for the first time on the 8th of July.

Now more interestingly, I haven’t had an injection of Test Phenylprop or anything else in about 10 days now and curiously my libido, morning wood and general sense of well being are far higher than they were on injections. This is despite being bandaged up and in compression with 4 drains. I’ve not normally gone that long without at least 1 injection and I’d be getting low t/e2 mental sides by now.

I’m having bloodwork tomorrow to see what my levels are but it seems there is some plausibility to my original thesis that I don’t actually have an issue with testosterone production but rather that my teenage gyno reached a certain maturity such that it was skewing my e2/t ratio and/or inhibiting the production of testosterone altogether at the HPA level entirely.

I’ll revert back again with bloodwork accordingly but to my mind this does raise the question of how we measure if someone is truly hypogonadal or not. Meaning to say is there an organ causing suppression rather than it being a production issue requiring exogenous T. I don’t think gyno needs to be that sizeable to cause a skew, it just needs to be mature enough.

 

[Nelson Vergel]

And u take 1000iu’s/ week, correct? How many injections of HCG do u do per week?

500 IU twice per week of hCG. 50 mg of T twice per week. Both in the same syringe

 

[tropicaldaze1950]

500 IU twice per week of hCG. 50 mg of T twice per week. Both in the same syringe.

Nelson, is your HCG compounded or do you purchase from India? Thanks.

 

[Nelson Vergel]

Nelson, is your HCG compounded or do you purchase from India? Thanks.

I get it from India. Click on the banner on the site that says cheap Ed drugs and use coupon ExcelMale20 for 20 percent off.

 

[tropicaldaze1950]

I get it from India. Click on the banner on the site that says cheap Ed drugs and use coupon ExcelMale20 for 20 percent off.

View attachment 45841

Thank you!

 

[babi]

Works for me, but YMMV



I take it daily to reduce the effects of extra estrogen. It does help in my protocol.

As said by most everyone, YMMV. It takes a while to get the effects you want dialed in (1+ years for me). In my case, too much E2= no libido, no erection. Too little E2, some libido, no ejaculation. So if you're in a happy spot, I'd suggest not to bother, but if you can identify the effects as too much estrogen, then DIM is an easy thing to try.

-RSR

How long DIM takes to show it's effect?