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Morten Hostrup, Anders Krogh Lemminger, Ben Stocks, Alba Gonzalez-Franquesa, Jeppe Kjærgaard Larsen, Julia Prats Quesada, Martin Thomassen, Brian Tate Weinert, Jens Bangsbo, Atul Shahaji Deshmukh (2022) High-intensity interval training remodels the proteome and acetylome of human skeletal muscle eLife 11:e69802
doi.org
Acetylation is what happens when a member of the small molecule group, acetyl, combines with different molecules. Researchers say acetylation can influence the behavior of proteins. So what this study found is that HIIT can reshape metabolism and boost skeletal muscle. The analysis revealed a notable increase in the production of proteins that build mitochondria, the power plants of cells, as well as muscle contraction-related proteins. I am going to say this same effect also applies to resistance training since there are periods of high intensity combined with periods of low intensity.
The importance of this study is HIIT improves skeletal muscle metabolism and enhances an obese person’s weight loss capacity if they are “diet-resistant."
High-intensity interval training remodels the proteome and acetylome of human skeletal muscle
Global proteomic and acetylomic analyses reveal how skeletal muscle adapts to high-intensity interval training including adaptations to processes regulating metabolism and contraction.
doi.org
Abstract
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on the proteome and acetylome of human skeletal muscle, revealing the response of 3168 proteins and 1263 lysine acetyl-sites on 464 acetylated proteins. We identified global protein adaptations to exercise training involved in metabolism, excitation-contraction coupling, and myofibrillar calcium sensitivity. Furthermore, HIIT increased the acetylation of mitochondrial proteins, particularly those of complex V. We also highlight the regulation of exercise-responsive histone acetyl-sites. These data demonstrate the plasticity of the skeletal muscle proteome and acetylome, providing insight into the regulation of contractile, metabolic and transcriptional processes within skeletal muscle. Herein, we provide a substantial hypothesis-generating resource to stimulate further mechanistic research investigating how exercise improves metabolic health.Acetylation is what happens when a member of the small molecule group, acetyl, combines with different molecules. Researchers say acetylation can influence the behavior of proteins. So what this study found is that HIIT can reshape metabolism and boost skeletal muscle. The analysis revealed a notable increase in the production of proteins that build mitochondria, the power plants of cells, as well as muscle contraction-related proteins. I am going to say this same effect also applies to resistance training since there are periods of high intensity combined with periods of low intensity.
The importance of this study is HIIT improves skeletal muscle metabolism and enhances an obese person’s weight loss capacity if they are “diet-resistant."
