High SHBG, low free T. TRT?

tareload · Jul 19, 2022

Jerajera said:
I've also seen very similar numbers between the Direct and Equilibrium Dialysis methods, despite everyone saying the Direct method is garbage

Almost, if you pretend the units of the direct RIA method are wrong or multiply the direct number by 10 as had been discussed. In reality the conversion factor more like 6-7. More info here.

Public Service Announcement: "Piss Poor" Direct RIA fT measurement (HELP is on the way)

Hey Folks, thought I would update the graph for free T reference ranges based on LC-MS/MS+ED and compare with Labcorp's direct RIA fT reference range. What the hell do you do with with your direct fT measurement if you want to compare with equibrium dialysis reference ranges? Take the Labcorp...

www.excelmale.com

arseniol · Jul 19, 2022

Jerajera said:
In my personal experience, the TruT calculator is completely off. I've posted the numbers somewhere and it wasn't even close. I've also seen very similar numbers between the Direct and Equilibrium Dialysis methods, despite everyone saying the Direct method is garbage

What do you mean by "Direct"? Do you mean from using total T, SHBG, and albumin with Vermeulen formula? Or do you mean RIA?

RIA is another world, maybe it has some meaning, but would need a conversion.

tareload · Jul 19, 2022

arseniol said:
What do you mean by "Direct"? Do you mean from using total T, SHBG, and albumin with Vermeulen formula? Or do you mean RIA?

RIA is another world, maybe it has some meaning, but would need a conversion.

See post above yours, # 21

arseniol · Jul 20, 2022

readalot said:
See post above yours, # 21

sorry, I missed it.

my lab suggested testing bioavailable through RIA, does it make sense?

arsenio7 · Aug 16, 2022

Systemlord said:
That's how it works. When I was diagnosed with low-T, my Total T was 91 ng/dL (3.2 nmol/L) and Free T below range, SHBG 11.

Actually, it is maybe better to have a total T that low to have the right diagnostic. Here, in Europe, if the total T is above 400 ng/dL the MD will skip all other tests and say that it is fine.