Extremely high SHBG

[Systemlord]

My liver function appears to be normal from my bloodwork results

https://imgur.com/a/VOU1eSp

Also my E2 came back quite low at only 12, the nurse told me I was bottomed out on E. Why do you recommend twice weekly instead of once per week? I thought the large once per week is what could possibly help lower the SHBG?

More stability is always a good thing keeping levels more stable, it should be enough and if it isn't you could always switch things up. This TRT game is all about trial and error, it will take awhile to see what works best for you.

You could do either protocol, good chance both will do the job. Question is which one will make you feel better. One large injection is sure to increase estrogen, whether it's a good thing is anyone's guess.

 

[MarkM]

The larger once weekly injections are better suited for the high SHBG individuals.

 

[amble]

For 25 your T is way too low.

. It would be appropriate to have one injection of TCyp probably 120-140mg per week (in one injection) it's the one large injection that may help reduce SHBG.

Kickstart doses are great, but one does of a Testosterone Ester a week will cause 'fun' spikes. Ten Tcy are effectively the same. They will not 'last' a week.

low T or Low T causing Thyroid a

Thyroid generates the feedback hormones for low T. Chronic low T exhausts the thyroid in some conditions which can mask other organic causes of hyPOthyroidism.

for 0.5cc (100mg/week) Test Enanthate and HCG 0.4cc 3x per week. Is this a good starting dose?

only if you ramp up to three of those T injections spread over a week within a few weeks.

importance of SHBG and free testosterone. The nurse said free testosterone is just the stuff "floating around".

There is not much incorrect about 'floating around'. It is "bio available" meaning in can be productively employed. SHBG steals free T never surrendering it. Bound T raises overall T scores but doesn't help you.

If your shbg continues to be unreasonably high it's time for you to import some Proviron.

 

[andrew1324]

Thanks for your input, I've been taking 130 mg / week so far and have been doing pretty good on that. No side effects that I can tell. But indeed I do feel better at the beginning of the week than the end.

Kickstart doses are great, but one does of a Testosterone Ester a week will cause 'fun' spikes. Ten Tcy are effectively the same. They will not 'last' a week.

Ten Tcy?

only if you ramp up to three of those T injections spread over a week within a few weeks.

I'm confused as to what you're recommending here

There is not much incorrect about 'floating around'. It is "bio available" meaning in can be productively employed. SHBG steals free T never surrendering it. Bound T raises overall T scores but doesn't help you.

The nurse told me the doctors approach was only to focus on Total T rather than Free, which is not good in my case. I got the vibe she felt it was unimportant when she said that.

 

[andrew1324]

Just got my results back after 4 weeks of being on TRT, attached my results.

My E2 and TT are way too high.
Total Testosterone : 69.5 nmol/L (2004 ng/dL)
Estradiol : 285 pmol/L (77 pg/mL)

I've been injecting 130mg Test E into thigh 1" 25g needle once every 6 days along with HCG 400iu 3x per week. I really havn't noticed much in terms of side effects other than not having as much energy as I did the first 2 weeks (maybe because of such high E?) I plan to do the water retention treadmill test later today.

I hope my doc's not gonna be pissed when I tell him I've been doing a higher dose than he originally recommended (100 mg/week). I thought it would be necessary since my SHBG has been so high and Free T has been so low..

I feel like I really need to have my Free T and SHBG tested as well but the doctors nurse receptionist didn't seem to think that was as important. I have a follow up appointment this week and plan to ask to get those tested from now on.

Why is my Total T so high? Would the high SHBG be making me hold on to T for a much longer time?

Whats the best route to go from here? Should I cut doses down big time? Start injecting 2x weekly?

Thanks for your help