High E2 Problems

Powerdome · Apr 2, 2018

Hello... I have been on TRT for a while and have been taking 40mg 3 times per week to combat E2 problems. I am trying not to need an AI.

My results last week were TT 575, FT was 10 and E2 was 92..............

I have switched to 25mg EOD to try lowering the E2 resonse. My question is has anyone withE2 problems tried a simliar protocol and found it lowers their E2?

Powerdome · Apr 2, 2018

Does pregnenolone or DHEA raise E2? Or do they help lower it? I am wanting to lower my E2 levels and decrease the anxious feelings I get from my E2 levels. I take 25mg EOD of T.

Vince Carter · Apr 2, 2018

From your other post I'd drop the DHEA entirely, it converts to E way too easily and you don't need to supplement it any way. Post your lab ranges because I'd bet you have the wrong E test.

Vince · Apr 2, 2018

I agree with Vince Carter stop taking your DHEA and pregnenolone. Make sure you're getting the right sensitive estradiol test for men.

Powerdome · Apr 2, 2018

Thanks for the response. I am not currently taking DHEA and pregnenolone. I should have made that clear. I was merely asking for advice to see if it would be a good adjunct to my program

Estradiol 92.00 pg/ml
Free-test 10.51 pg/ml
T.T 5.75 ng/ml
Cortisol 12.04 ug/dl

CoastWatcher · Apr 2, 2018

Powerdome said:
Thanks for the response. I am not currently taking DHEA and pregnenolone. I should have made that clear. I was merely asking for advice to see if it would be a good adjunct to my program

Estradiol 92.00 pg/ml
Free-test 10.51 pg/ml
T.T 5.75 ng/ml
Cortisol 12.04 ug/dl

What estradiol test was run? LC, MS/MS, the sensitive test? If you aren't sure, post the ranges associated with the test from your lab work. Those are a sure giveaway as to which test.

Powerdome · Apr 2, 2018

The results didn't have a ref range. I popped off a message to the hospital asking those questions...thanks...will post as soon as I know

Powerdome · Apr 2, 2018

I will ask to have my SHBG tested next time also. Perhaps there is an issue there?

Powerdome · Apr 4, 2018

The range was under 60. There was no lower limit.

Vince · Apr 5, 2018

The range for LC,MS/MS, the sensitive test for men is 8.0-35.0

Powerdome · Apr 5, 2018

I doubt whether it is a sensitive test...thanks

Vince Carter · Apr 5, 2018

Powerdome said:
I doubt whether it is a sensitive test...thanks

You need this test because any other is for females and will tend to overestimate E levels in males. The test is usually written as Sensitive or UltraSensitive LC/MS/MS.

You should do SHBG but as a direct thing for E it could be a problem if SHBG is low Free T tends to be very high (because there is less SHBG to bind), which further goes in to Free Estrogens (possibly) being very high as well.

Powerdome · Apr 5, 2018

Yes, I intend to have my SHBG done as well as my DHEA and either pregnenolone or progesterone (not sure which is better)
I would guess that my SHBG is high as my Free Test is low unfortunately

I have been on my new protocol of 25mg EOD for only a week so will see how that effects my next draw in a couple months.

Powerdome · Apr 5, 2018

Also, a question regarding blood draws. Fasted or not. I have read it doesn't matter to much, but again have read fasted is better? So much conflicting info!

AIs are also a topic that is confusing. Some well know TRT doctors use them and others hate them. Its a minefield haha

Vince · Apr 6, 2018

Powerdome said:
Also, a question regarding blood draws. Fasted or not. I have read it doesn't matter to much, but again have read fasted is better? So much conflicting info!

AIs are also a topic that is confusing. Some well know TRT doctors use them and others hate them. Its a minefield haha

I always fast 12 hours before doing labs, most doctors run labs on more than just testosterone panel.