E2 sweet spot, it's a ratio

[slicktop]

Hi guys:
My numbers are:
E2 Sensitive 43
Total T 685
Free T 154.8
SHGB 15
Can someone calculate my ratio and tell me how I‘m doing please?
Thanks

Hard to do without ranges. I don't recognize the free T test that goes that high as being from LabCorp or Quest. Is that a Tru-T value? Anyhow- please consider starting a fresh post for this, but in general, if you feel good those numbers are nothing to cause you concern, although your E2 does seem a bit high to me, personally.

 

[ssc68]

Hard to do without ranges. I don't recognize the free T test that goes that high as being from LabCorp or Quest. Is that a Tru-T value? Anyhow- please consider starting a fresh post for this, but in general, if you feel good those numbers are nothing to cause you concern, although your E2 does seem a bit high to me, personally.

These are Quest numbers.
Quest Ranges:
Total T: 250-1100(ng/dl) My test was 685
Free T: 35-155(pg/ml) My test was 154.8
E2: <\= 29(pg/ml) My test was 43
I do feel pretty good with these numbers. Thanks for your response.

 

[ssc68]

So, I've been taking .25 Arimidex 2X a week for 4 weeks. My E2 went from 63 pg/ml to 43 pg/ml (Ultra sensitive). Quest says it should be lower or ewual to 29 pg/ml Ultra sensitive.
Should I try lowering the E2 some more, (closer to 29 pg/ml ultra sensitive which is the ultra sensitive range) or should I leave it alone at 43 pg/ml?

As per my high E2 symptoms. The sensitive nipples are gone and the bloated feeling/water retention has improved a lot. My doctor gave me an appointment for six months from now. I take the Arimidex 24 hours before my T shot and then 3 days later.

 

[Gman86]

So, I've been taking .25 Arimidex 2X a week for 4 weeks. My E2 went from 63 pg/ml to 43 pg/ml (Ultra sensitive). Quest says it should be lower or ewual to 29 pg/ml Ultra sensitive.
Should I try lowering the E2 some more, (closer to 29 pg/ml ultra sensitive which is the ultra sensitive range) or should I leave it alone at 43 pg/ml?

As per my high E2 symptoms. The sensitive nipples are gone and the bloated feeling/water retention has improved a lot. My doctor gave me an appointment for six months from now. I take the Arimidex 24 hours before my T shot and then 3 days later.

Are any mood/ energy/ sexual symptoms any better or worse with the slightly lower E2?

 

[ssc68]

Are any mood/ energy/ sexual symptoms any better or worse with the slightly lower E2?

Yes sexually, I have increased libido, fuller erections and last longer. Also, I am getting morning wood which was not happening when my E2 was at 63/69.
I can't say I have noticed any mood changes or energy. I can tell you this, I don't feel as bloated and I am no longer retaining water in my lower legs. It also got rid of sensitive nipples which I hated.

 

[meelord]

I have achieved this experimenting with three different methods....one was low dose AI, two was no AI, but the removal of HCG from my regiment, and 3 was no AI, using HCG, and lowering my dose of T. All three worked in gettin’ my E2 and SHBG in close proximity range.

Which of the three was subjectively best for you feeling wise?

 

[hurleytmark]

These are Quest numbers.
Quest Ranges:
Total T: 250-1100(ng/dl) My test was 685
Free T: 35-155(pg/ml) My test was 154.8
E2: <\= 29(pg/ml) My test was 43
I do feel pretty good with these numbers. Thanks for your response.

I have the exact free T level (154.8) on quest scale as a natty. My Total T is 778 ng/dl though. Based on your shbg level, I must be in the low 20s.

I still suffer ED even though my levels are good. I wonder where my E2 sits. I've been as high as 62 pg/ml and as low as 50 pg/ml on a sensitive scale. My free T rises as E2 goes down, so it should be lower than 50 pg/ml

Are you on TRT?

 

[SkiDaddy]

Below are my numbers Using Scrotal Cream for T, HCG .25iu twice weekly, NO AI
So, what should I change, I have NO Libido?

Total T 1002
E2 Sensitive 34.6
Free T 33.8
SHGB 29.0
Prolactin 5.8 ng/ml

 

[Cataceous]

Below are my numbers Using Scrotal Cream for T, HCG .25iu twice weekly, NO AI
So, what should I change, I have NO Libido?

Total T 1002
E2 Sensitive 34.6
Free T 33.8
SHGB 29.0
Prolactin 5.8 ng/ml

Have you experimented with lower doses? Ideally you would try various peak levels of total testosterone in the 500-800 ng/dL range, leaving substantial time between changes.

Do you know what your DHT is? It can be quite high with use of a scrotal transdermal product. This in turn can reduce estrogenic activity, possibly affecting libido. DHT acts as both an aromatase inhibitor and as an estrogen receptor antagonist.

Have you experimented with raising dopamine activity? There are various medications and supplements to try.

I didn't regain satisfactory libido until I tried restoring other upstream hormones, and GnRH in particular through the use of gonadorelin. There is too little data to say if others would benefit from such treatment.

 

[aneuman]

Below are my numbers Using Scrotal Cream for T, HCG .25iu twice weekly, NO AI
So, what should I change, I have NO Libido?

Total T 1002
E2 Sensitive 34.6
Free T 33.8
SHGB 29.0
Prolactin 5.8 ng/ml

I hear you. Same boat.

My numbers are

Total T: 787 ng/dL
E2: 36 pg/ml
Free T: 88.7 pg/ml
Bioavailable T: 190.1 ng/dL
SHBG: 44 nmol/dL
Prolactin: 6.1 ng/ml
DHEA-S: 228 mcg/dL
DHT: 55 ng/dL

I'll visit the doctor soon, I'll let you know if there's any change in protocol. I'm on enclomiphene 12.5 ED.

 

[SkiDaddy]

GnRH

I have tried Testosterone Levels between 500-800 does not make a difference.
I also tried and still do to increase Dopamine, by using Mucuna-Pruriens, DMAE, Life Extensions (dopa-mind), and Berberine.
DHT = 250 ng/dL
DHEA = 392 ug/dL

Is there a test for GnRH ?

 

[eli]

Below are my numbers Using Scrotal Cream for T, HCG .25iu twice weekly, NO AI
So, what should I change, I have NO Libido?

Total T 1002
E2 Sensitive 34.6
Free T 33.8
SHGB 29.0
Prolactin 5.8 ng/ml

Drop the HCG
See if that'd help. Tales 6 weeks

 

[Systemlord]

I'm on enclomiphene 12.5 ED.

This is more than likely why you have no libido.

 

[SkiDaddy]

Drop the HCG
See if that'd help. Tales 6 weeks

I was off HCG for 9 months and started back at Defy request on 01/24/2022.
I never noticed any difference except I feel better with HCG.

P.S. I was diagnosed with Venous Leakage by penile doppler a year ago, it is getting better by about 50% with a lot of work.
Not sure if that apples to No Libido.

keep us posted about you doctor visit about enclomiphene.

 

[eli]

I was off HCG for 9 months and started back at Defy request on 01/24/2022.
I never noticed any difference except I feel better with HCG.

P.S. I was diagnosed with Venous Leakage by penile doppler a year ago, it is getting better by about 50% with a lot of work.
Not sure if that apples to No Libido.

keep us posted about you doctor visit about enclomiphene.

I don't believe that should because libido is mental and chemicals.

 

[Wolverine]

I was off HCG for 9 months and started back at Defy request on 01/24/2022.
I never noticed any difference except I feel better with HCG.

P.S. I was diagnosed with Venous Leakage by penile doppler a year ago, it is getting better by about 50% with a lot of work.
Not sure if that apples to No Libido.

keep us posted about you doctor visit about enclomiphene.

@Cataceous is on the money. I was on scrotal gel. DHT was at 287 with 1 click (50mg). Adversely affects E and increases NE. All other lab values were good. No libido, poor EQ etc.

 

[Cataceous]

...
Is there a test for GnRH ?

I see Labcorp has one. But in most guys on TRT it is suppressed to very low levels, along with its downstream hormone LH. Here's my speculation on why loss of GnRH and kisspeptin can be bad:

Kisspeptin suppression under TRT: Can it affect mood and libido?

TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men. I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be...

www.excelmale.com

Is GnRH suppression hurting us?

Admittedly the last thing we need is some other nebulous danger to worry about that may not even exist. Read on at your peril. TL;DR: Testosterone replacement therapy suppresses the production of GnRH. Receptors for GnRH are found in places besides the pituitary. One animal model suggests GnRH...

www.excelmale.com

I document a pituitary restart with gonadorelin (GnRH):

Pituitary restart while on TRT: promising initial results with GnRH plus enclomiphene

TL;DR: Over a period of seven weeks, treatment with GnRH and enclomiphene raised LH and FSH from around 0.1 mIU/mL to about 1.0 mIU/mL, even though TRT and hCG dosing were continued. Subjective results have been encouraging. I had written previously on the subject of GnRH suppression on TRT...

www.excelmale.com

 

[SkiDaddy]

I went on the Defy website and tried to find Kisspeptin with No luck.
Would you have to take both enclomiphene and Kisspeptin together.

 

[Cataceous]

I went on the Defy website and tried to find Kisspeptin with No luck.
Would you have to take both enclomiphene and Kisspeptin together.

Kisspeptin cannot legally be sold in the U.S. as a medication. It's only available through peptide sites for "research".

Gonadorelin—GnRH—is a legal medication, and Hallandale Pharmacy has offered it.

Enclomiphene may be needed if you want the pituitary to respond well to GnRH and produce LH. However, if you're continuing with hCG then the LH is less necessary.

 

[SkiDaddy]

Thanks for the replies.
I tried Gonadorelin and it gave my bad headaches.