Hey guys, would I qualify for TRT based on my labs?

[Dr Justin Saya MD]

Is zuclomiphene an identical agonist as E2 is? Not just in terms of Ki but EC50 and possibly even other more complicated measurements of end target response.

In other words, there are ERa and ERb receptors, does zuclomiphene bind identically to these as does E2?

I wonder if zuclomiphene has a bit of a different response from the receptor than E2 does and possibly explaining the poor response most men report.

I've even thought that clomid's estrogen antagonist effects were responsible for the poor response, but the symptoms these men report sound more high E2 than low, but not always.

I'm not aware of this biochemical data on zuclomiphene if it exists. I would suspect there would be greater likelihood of further study on receptor dynamics with the enclomiphene isomer, especially considering they are attempting FDA approval for the isomer separate from clomiphene itself.