I have used 50mcg daily and it increased my level 25 pg/ml. It brought me from 15 up to 40.20 mcg daily, but my E2 is still little bit higher.. As long as I am on trt I more and more think it is about test: estradiol progesterone .. I feel more progesterone needs more estradiol. Suprisingly I felt best sexual function 90-100 pg/NL of e2..
20 mcg is not likely to bring you all the way up to 90-100.