Factors Affecting Protocol Change

[JWSimpkins]

Has anyone here had to change their drug dosages (i.e. Test, hCG, AI) when they started hitting the gym and losing body fat/gaining muscle?

 

[robs2nd75]

In theory the leaner you become the less T you should need but we are HPTA suppressed, no? Though I am becoming leaner I have required a higher dose of T as time passes and this has elevated my e2. There are so many variables that influence our hormones I think it would be almost impossible to conclude w/ certainty that bf change alone engendered a need for more/less T. I seem to remember one or two rat studies that demonstrate that obese mice require more T but in humans.....Interesting question

 

[JWSimpkins]

In theory the leaner you become the less T you should need but we are HPTA suppressed, no? Though I am becoming leaner I have required a higher dose of T as time passes and this has elevated my e2. There are so many variables that influence our hormones I think it would be almost impossible to conclude w/ certainty that bf change alone engendered a need for more/less T. I seem to remember one or two rat studies that demonstrate that obese mice require more T but in humans.....Interesting question

That's interesting Rob that you would need more T as you got leaner. I would expect at the very least one would need less AI when body fat was reduced. I have lost a decent amount of body fat over the last two months, so I'm interested to see if this will affect my blood work in a couple of weeks.

 

[robs2nd75]

I'm guessing I need more b/c my doc is reluctant to prescribe hcg and I'm definitely suppressed at this time. I also have severe sleep apnea and diabetes = too many variables. I will note, and this of course is anecdotal, but my A1c seems to affect the amount of T I need more than my weight/ bf %. (my weight shifting about 20 lbs and my lifts increasing about 25-30% has had less AND if my sleep is off everything is off