I've heard before that being on T replacement can cause a mineral shift like your stating and make you hold onto more water potentially. Really curious as to the specifics of that if anyone knows....
TRT can cause water retention and high blood pressure during the first weeks of treatment. This article mentions ways to deal with that issue
www.testosteronewisdom.com
TESTOSTERONE EFFECTS ON BODY WATER
The pioneers in the androgen field recognized that
testosterone administration in androgen-deficient
men and in healthy women was associated with significant
retention of sodium, chloride, and potassium,
sulfur and phosphate (Knowlton et al, 1942;
Wilson 1996). Knowlton et al. (1942) reported that
much of the early weight gain could be accounted
for by water retention in association with retained
electrolytes and protein. When administration of
androgen is topped, sodium, potassium, and water
are lost quickly (Knowlton et al, 1942; Wilson
1996). Significant water retention resulting in edema
is unusual in healthy, hypogonadal men, who
are receiving replacement doses of testosterone.
However, supraphysiologic doses of testosterone
can result in edema and exacerbate heart failure
when given to men with pre-existing heart or kidney
disease. In clinical trials of testosterone replacement
in older men (Snyder et al, 1999; Sih et al,
1997, Tenover 1998; Kenny et al, 2001), the frequency
of edema and congestive heart failure in
testosterone-treated men has been very low.
This is the first controlled study demonstrating that testosterone increases ECW. Previous data concerning the effects of testosterone on plasma volume (19, 20) and urinary sodium excretion (18, 21) are limited and conflicting. The underlying mechanism is unknown, but several possibilities exist.
Testosterone could act directly on the kidney, because androgen receptors are expressed in renal tubules (31). There is evidence that androgens stimulate the expression of the angiotensinogen gene in the kidney (32, 33). Therefore, androgens could activate the local renal RAAS to stimulate sodium and water retention through an autocrine or paracrine mechanism (34). The epithelial sodium channel plays an important role in the sodium balance, as demonstrated by genetic abnormalities in its activity, such as in Liddle’s syndrome (35). It has recently been reported that androgens increase mRNA expression of the α-subunit of the epithelial sodium channel in a human renal cell line (36), providing a potential mechanism of sodium and water retention by testosterone.
Abstract. Context: Symptoms of fluid retention in GH-deficient patients during GH replacement are greater in men than in women, suggesting that testosteron
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