Drop in SHBG after starting TRT

IamNotShepard · Jun 22, 2019

Hi,

How many of you guys noticted lowered SHBG after starting TRT? I am most curious about people who had high-ish SHBG before taking testosterone. For me the drop was almost 50%.

fifty · Jun 22, 2019

Mine dropped from a high of like 70 to 45 after about 9 months.

sh1973 · Jun 22, 2019

I’ve had high shbg for the last decade and trt hasn’t budged it at any dose.

Systemlord · Jun 22, 2019

Almost everyone notices a drop in SHBG after starting TRT, some see an increase do to high insulin and obesity suppressed their SHBG.

antelopers · Jun 22, 2019

Mid-range shbg here, hasn't changed at all on trt.

TLR · Jun 22, 2019

Mine wasnt tested when I started......however it went up from 17 to 30 in about a year when I dropped dose from 200 mg a week to 100. What dose are you taking? Higher doses are known to decrease it even more than usual.

madman · Jun 22, 2019

Not everyone will notice a lowering of SHBG when on trt and most will only notice a small drop in levels.

Larger declines in SHBG are usually seen when one is using higher doses of androgens such as 200 mg/week or when using steroid doses 250-600 mg/week.

T 150 mg/week (75 mg every 3.5 days).....SHBG went from 35--->30 nmol/L

Nelson Vergel · Jun 23, 2019

Like Madman said.

Anabolic steroids and TRT decrease SHBG, DHEA, pregnenolone and progesterone in men.

IamNotShepard · Jun 23, 2019

Nelson Vergel said:
Like Madman said.

Anabolic steroids and TRT decrease SHBG, DHEA, pregnenolone and progesterone in men.

My SHBG was 70 nmol/l prior to TRT and went all the way down to 34 nmol/l (similar to fifty, but my was lowered even more) The drop was significant and the dosage is not that big. It's 30mg EOD which would translate to 105mg weekly. What could be the reason for such a drop? Is that a sign of high androgen sensitivity?

Nelson Vergel · Jun 24, 2019

IamNotShepard said:
My SHBG was 70 nmol/l prior to TRT and went all the way down to 34 nmol/l (similar to fifty, but my was lowered even more) The drop was significant and the dosage is not that big. It's 30mg EOD which would translate to 105mg weekly. What could be the reason for such a drop? Is that a sign of high androgen sensitivity?

I am not sure if you are taking anastrozole. Anastrozole decreases HDL even more.