I have been on TRT for 16 months, my hematocrit levels starting going past the max value after 2 months. I started donating blood every 2 months and levels have been perfect. I stsrted at 50mg every 3.5 days and 1/2 a anastrozol. My estrogen levels are always perfect, but my T was sometimes above max range, dropped to 40mg and brought levels to 800 range, but started getting bad back acne, so lowered it to 35. I am 51, even lowering dose, I still need to donate blood.