Does HCG Cause Alzheimer's Disease?

[Dad51]

I've come across a few studies online that seem to correlate high levels of HCG to increased risk of Alzheimer's disease. Something about it increasing the plaque formation linked with Alzheimer's disease when HCG levels are chronically elevated possibly because it causes chronically higher than normal levels of LH. I feel great on HCG but not worth getting Alzheimer's from it. Is any of this true?

Here's an excerpt from one such study:
Specifically, luteinizing hormone, which is increased with age in both men and women (in response to removal of negative feedback), has surfaced as a potentially powerful player in the risk and onset of Alzheimer's disease. Mounting evidence in basic research and epidemiological studies supports the role of elevated luteinizing hormone in exacerbating age-related cognitive decline in both males and females. This review summarizes the recent developments involving luteinizing hormone in increasing the cognitive deficits and molecular pathology characteristic of Alzheimer's disease.

 

[Fernando Almaguer]

I've come across a few studies online that seem to correlate high levels of HCG to increased risk of Alzheimer's disease. Something about it increasing the plaque formation linked with Alzheimer's disease when HCG levels are chronically elevated possibly because it causes chronically higher than normal levels of LH. I feel great on HCG but not worth getting Alzheimer's from it. Is any of this true?

Here's an excerpt from one such study:
Specifically, luteinizing hormone, which is increased with age in both men and women (in response to removal of negative feedback), has surfaced as a potentially powerful player in the risk and onset of Alzheimer's disease. Mounting evidence in basic research and epidemiological studies supports the role of elevated luteinizing hormone in exacerbating age-related cognitive decline in both males and females. This review summarizes the recent developments involving luteinizing hormone in increasing the cognitive deficits and molecular pathology characteristic of Alzheimer's disease.

HCG does not increase LH, it mimics it. I wonder if that makes a difference here.

 

[Guided_by_Voices]

Step one for people concerned about dementia is to follow the recommendations in Dr. Bredesen's dementia reversal protocol. Even if a study showed HCG increased risk, if it was done in a population which was trying to give themselves dementia (which is the majority of people in th US) then the study would not be valid for healthy people.

 

[Phil Goodman]

HCG does not increase LH, it mimics it. I wonder if that makes a difference here.

^
This


If they are blaming LH(or at least considering it as a possible factor) then we’d need to know if a substance that mimics it would have the same effect. If not, then it seems trt(with or without HCG) would lower the risk since at least on the front, since it causes LH levels to plummet to practically zero.


Can you link to the studies you’re referencing?

 

[Guided_by_Voices]

Elevated LH could also be a marker for low T, which is a risk factor for Dementia, so it may not be the LH at all.

 

[Cataceous]

Good discussion and references here:

Thread 'HCG and elevated LH in Alzheimer patients'

Jun 5, 2022

While browsing alzheimmer info for my girl's aging mother, I came accross some studies that made me think my HCG use...

Elevated gonadotropin levels in patients with Alzheimer disease​

Elevated gonadotropin levels in patients with Alzheimer disease - PubMed

Gonadotropin levels are elevated in some patients with AD, ie, women not taking estrogen. Elevated gonadotropin levels may have a role in the production of amyloid-beta protein, which is related to formation of senile plaques. Therefore, elevated gonadotropin levels may be involved in the...

pubmed.ncbi.nlm.nih.gov

The Contribution of Luteinizing Hormone to Alzheimer Disease Pathogenesis​

The Contribution of Luteinizing Hormone to Alzheimer Disease Pathogenesis - PMC

Several hypotheses have been proposed that attempt to explain the pathogenesis of Alzheimer Disease (AD) including theories involving senile plaque and neurofibrillary tangle formation, increased oxidative stress, and cell cycle abnormalities, since ...

www.ncbi.nlm.nih.gov

Stuff like this made me pause:

There is growing evidence supporting a role for gonadotropins, particularly LH, in AD pathogenesis beginning with the finding of a two-fold increase in circulating gonadotropins...​

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