Yes and probably. I perceived improvements in cognition that correlated with the use of gonadorelin and enclomiphene. However, one possible confounding factor is that I had started taking selegiline in a similar time frame. I would tend to attribute more of the possible improvements to the GnRH, but for all I know there could be a synergistic effect. I doubt increased LH was much of a factor, as levels barely entered the normal range. Experiments in mice are promising: "A striking observation was that GnRH promoted adult neurogenesis despite aging." "GnRH led to an amelioration of aging-related cognitive decline .... Thus, prolonged elevation of systemic GnRH can cumulatively yield actions on the brain;..." Discussed here.
Thank you for the link;
It might work, but there are caveats. It's unclear what's best with respect to dosing. My guess is that small, frequent doses will be more effective than large, infrequent doses. Additionally, kisspeptin-10 is probably less effective than the endogenous kisspeptin-54. Then there's the problem of determining efficacy. There is a GnRH blood test, but it's not clear to me if it can provide a clear indication of what's going on with a pulsatile hormone. An LH test is likely to be more accessible, though timing could still be an issue, and you'd need to use enclomiphene, at least temporary, to overcome negative feedback at the pituitary.
whats ur selegeline protocol? How often do u take it each week, how many mgs each dose, time of day, food or not with food, orally or sublingually?
Optimistically, the selegiline and GnRH have so sharpened my memory that it just seems like you ask this all the time. I take 2.5 mg orally upon waking each day. This is on an empty stomach and without food. I've been on it since 2020.
LOL. In @Gman86 's defense, you might have changed your protocol over time?
Pretty modestly. I started with 1.25 mg daily and increased to 2.5 mg after a few months. I've stayed with 2.5 mg since then except for briefly trying 3 mg, which made no perceptible difference.
I know, I've been unsuccessfully looking for kisspeptin-54 before.
My best guess is two to three months. The questions are: How long does it take the GnRH neurons to recover from an atrophic state? And how long does it take to achieve a normalized response to renewed GnRH signaling?
Thank you,
this is what brain fog will do to ya lol. Sorry brotha. I’m gonna save ur response so I don’t accidentally ask again in the future. Thanks for responding for the 300th time tho lol. Honestly appreciate it lol
In general sublingual delivery makes me a little uneasy. You get these large spikes in serum levels, which may be undesirable. I did some experimenting with sildenafil, and sublingual proved to be a sure way to induce side effects, whereas oral was ok. Arguably dose titration would help, given the better efficiency of sublingual delivery. There are situations where pulsatile delivery could be advantageous. I'm thinking of hormones that have natural pulsatile delivery, such as testosterone and GnRH. I don't have anything specific to add about selegiline. I wonder if the apparent half-life is reduced with sublingual delivery—and does this matter with a suicide inhibitor?
Really appreciate the detailed response. Very helpful. l took a little break from selegiline, but I think I’ll be starting it back up in a week or so, and when I do, I might try taking it orally, starting around 2.5mg ED, or EOD. Have really only tried it sublingually, at least consistently. I know @BadassBlues also enjoys taking it orally. He uses 5mg/ day, IIRC
That seems kinda personal to reveal on a public forum don't you think?
I think we’re all pretty open here, but I probably could have worded that better hahah
No comment
