Does a high hematocrit change your blood's clotting profile? High altitude vs TRT.

[Systemlord]

Does having a high hematocrit mean your blood is more likely to clot? This study looks at a city where people with the highest hematocrit in the world live and work.

 

[Vince]

Definitely both increase thrombotic risks

Is it safe for men with history of PE and on blood thinners to start testosterone ?

There are no published studies conducted on men with a history of pulmonary embolism (PE) who are taking blood thinners and want to use testosterone replacement therapy (TRT). However, they do provide a broad overview of the relationship between TRT and the risk of venous thromboembolism (VTE)...

www.excelmale.com

 

[aloetard]

Extra workload in compromised individuals is a real concern. Wish more (any) youtubers would cover plasma viscosity and whole blood viscosity.

TRT and Cardiovascular Disease

Testosterone replacement therapy and cardiovascular disease (2022) Jeremy M. Auerbach and Mohit Khera The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective...

www.excelmale.com

 

[aloetard]

Some of this is useful fyi regardless of phlebotomy arguments.

 

[aloetard]

Interesting question...

 

[Seagal]

Did anyone here with high hematocrit from TRT measure their blood viscosity?

 

[Seagal]

Extra workload in compromised individuals is a real concern. Wish more (any) youtubers would cover plasma viscosity and whole blood viscosity.

TRT and Cardiovascular Disease

Testosterone replacement therapy and cardiovascular disease (2022) Jeremy M. Auerbach and Mohit Khera The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective...

www.excelmale.com

What if blood viscosity is increased but blood pressure is not affected? Are the blood vessels dilated to adapt to increased viscosity, or is some 'lubrication parameter' increased?

 

[aloetard]

What if blood viscosity is increased but blood pressure is not affected? Are the blood vessels dilated to adapt to increased viscosity, or is some 'lubrication parameter' increased?

In relatively healthy individual yes there is some room to adapt.

Nitric Oxide in the Vasculature: Where Does It Come From and Where Does It Go? A Quantitative Perspective

Nitric oxide (NO) affects two key aspects of O[2] supply and demand: It regulates vascular tone and blood flow by activating soluble guanylate cyclase (sGC) in the vascular smooth muscle, and it controls mitochondrial O[2] consumption by inhibiting ...

www.ncbi.nlm.nih.gov

Vasodilation - Wikipedia

en.m.wikipedia.org

For someone with significant hardening then not so much room. There's a bunch of other details in my other thread. I used to post details ad nauseum but will keep it high level unless you really want the nitty gritty. Good questions.

 

[aloetard]

Did anyone here with high hematocrit from TRT measure their blood viscosity?

I haven't officially measured it using testing that hasn't been adopted in any widespread sense. I use the poor man's test when I give blood. If it is coming into the tube like water and the phlebotomist compliments me, I am happy. They can tell you the stories of morbid patients that have blood viscosity that is really thick. Think about the wear and tear on the endothelium in that case. Your body may accommodate for a while but then?

 

[aloetard]

lubrication parameter

Short of a graduate fluid mechanics course, this thread is decent:

Hematocrit drives Blood Viscosity- Does that Matter in Men on TRT? Effect of Altitude?

On this post see second video.

 

[Seagal]

Your body may accommodate for a while but then?

Maybe it can accommodate easily within a particular range. I don't know.

 

[Seagal]

Short of a graduate fluid mechanics course, this thread is decent:

Hematocrit drives Blood Viscosity- Does that Matter in Men on TRT? Effect of Altitude?

On this post see second video.

That's a pleasant change here, someone who does not make absolute claims based on bits of a puzzle.

 

[Seagal]

Watched the videos, read the paper.
I can just report that my hematocrit is 54% and my resting BP is no more than 120/80.

 

[Seagal]

Think about the wear and tear on the endothelium in that case.

If I understand correctly then higher hematocrit does not mean more shear (wear and tear) to the endothelium.

 

[aloetard]

does not mean

Correct. If blood vessel is compliant then it can compensate for higher viscosity. Without compliance (atheroschlerotic disease), absolutely more shear with higher viscosity which begets vicious cycle.

Third video:

Hematocrit drives Blood Viscosity- Does that Matter in Men on TRT? Effect of Altitude?

Competing effects:

Hematocrit drives Blood Viscosity- Does that Matter in Men on TRT? Effect of Altitude?

Reducing dose and increased my hematocrit.

www.excelmale.com

Viscosity will eventually win out if high enough and for long enough by consuming physiogical reserves. High viscosity for sustained periods.....bad, based on what we know today.

 

[aloetard]

Watched the videos, read the paper.
I can just report that my hematocrit is 54% and my resting BP is no more than 120/80.

That is encouraging; two people can have the same HCT and dramatically different whole blood viscosity. Why? They have very different plasma viscosities (inflammation, disease). Hct doesn't tell the whole story of whole blood viscosity.

Congrats!

 

[Seagal]

Heard about methylene blue for HCT reduction. I don't have any experience or serious knowledge about it.


Methylene Blue as an Agent for Reducing Red Blood Cell Count

https://journals.sagepub.com/doi/abs/10.3181/00379727-31-7396p

 

[aloetard]

Heard about methylene blue for HCT reduction. I don't have any experience or serious knowledge about it.


Methylene Blue as an Agent for Reducing Red Blood Cell Count

https://journals.sagepub.com/doi/abs/10.3181/00379727-31-7396p

I had not. Thank you for the link.

Interesting reading.

PharmGKB

www.pharmgkb.org

Methylene Blue - StatPearls - NCBI Bookshelf

 

[aloetard]

 

[Ribeye]

Does having a high hematocrit mean your blood is more likely to clot? This study looks at a city where people with the highest hematocrit in the world live and work.

Does having a high hematocrit mean your blood is more likely to clot? This study looks at a city where people with the highest hematocrit in the world live and work.

This is fascinating work. thanks for posting. As one who nearly depleted my iron, it was a stupid decision I made because a primary care doc, not my HRT provider, convinced me I was going to have a stroke if my HCT didn't come down. He then sent me to hematologist, who was more knowledgeable, and didn't think I even needed to donate with an HCT at 51%. Bottom line, my HRT provider that I should have trusted, was telling me the truth all along and not to worry about it until it gets to at least 54%. Since I now have my apnea under control, it has never risen to that level.