On the dopaminergic front, a lot of the things I’ve had success with are highly related to that, and the ones I haven’t done well with are at times noted to increase serotonin, which is your dopamine is too low isn’t great.
Pregnenolone can do a lot related to PFS but has studies showing a dose dependent increase in dopamine response to stimulus. I didn’t get much out of lower doses but on 400mg I like it. Selegiline, an MAO-B inhibitor, also helped immensely, particularly when combined with that, but I’d be careful with that one. Currently coming off it because it appears to interact poorly with my levothyroxine/T4, and was the cause of massive cramps and rapidly increased intestinal movement that was too much for me. Before getting T4 back it was all great, sans having to be careful not to get too caught up in trivial things since everything felt great. Without enough T3, I feel like crap, and without T4 alongside that, I have erectile dysfunction with retaining blood in my penis. Increasing ketones also helps and has similar theories behind it.
If it wasn’t for that, high dose pregnenolone and HCG and potentially selegiline together would probably work wonders for a lot of goes with PFS like me. Test helps a lot too of course.
