Cialis Not working, Highest Dosage?

[Rick993]

Alright, so the effects of Cialis have really started to dwindle. Yesterday I took 20mg and I really couldn't even feel it. When I used to take 10 my penis would look large and in charge even when it was flaccid and I could get a rock hard erection in a moments notice. Has my body adapted to it? Whats the highest dosage anyone has tried? Any other input?

Tadalafil is also used to treat pulmonary hypertension (PAH) under the trade name Adcirca. In this manner the usual starting dose is 40mg daily, and titrated up to 60mg (20 mg TID) depending on the response. You really have to be conscious of the nitrate interaction, or you’ll be found unconscious. Tadalafil - Pulmonary Hypertension Association

 

[Rick993]

Also don’t be quick to go for an implant based on ultrasonography. Angiography of the Internal iliac to the internal pudendal artery is the gold standard; combined with angioplasty it is 75-80% effective in males where PDE5 no longer works. Essentially they are utilizing the technology used to treat atherosclerotic heart disease, in the penile arteries. TCT-515 PUDENDAL ARTERY ANGIOPLASTY FOR THE TREATMENT OF COMPLEX ERECTILE DYSFUNCTION IN MALES | JACC: Journal of the American College of Cardiology
Find yourself an interventional cardiologist or interventional radiologist with experience in small vessel peripheral artery disease. They usually are at the academic centers like UC Davis, etc.

 

[Rick993]

And as we all know pineapple juice retards the breakdown of PED5 drugs. These chemicals inhibit key drug metabolizingenzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. So pineapple juice greatly increases the prolonged circulating levels of PED5 drugs and also the side effects (priapism)

 

[DorianGray]

And as we all know pineapple juice retards the breakdown of PED5 drugs. These chemicals inhibit key drug metabolizingenzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. So pineapple juice greatly increases the prolonged circulating levels of PED5 drugs and also the side effects (priapism)

Pineapple juice? Interesting. Grapefruit juice enhances the effects of other drugs, I wonder if it has a similar effect on PDE 5? I've tried to increase the effects using NO stimulating supplements but that didn't seem to have any effect. Maybe time to try a pineapple, grapefruit, Super Beets cocktail.

 

[Mountain Man]

For Vince and Mountain Man: at those higher dosages do you ever worry about the PDE5 inhibitors losing their efficacy to where you cant use them? I am taking 3mg Cialis a day and add 50mg Viagra for added duration when I can. I am nervous about escalating these dosages and ultimately not being able to use these drugs anymore. (I am 53 and have some mild venous leak).

Not really. I use viagra only for sex, taking cialis for that and other reasons. Viagra works most of the time. There are a lot of times it works ok, and some times where it works unbelievably well. I notice that when I did not do a lot of physical stuff that day, or have an empty stomach it is fantastic. Also, how my wife looks, responds, or her desire also are a major factor as well.

I think that guys who speak about these meds often overlook all these various factors. I am 66, with my wife only for 33 years, so there are a lot of variables in place. If I have an average night, it is probably not the meds. Sex for me is going to ebb and flow a bit. Two nights ago my wife had 5 orgasms in the 45 minutes and said it was the best sex of her life. The key is to approach each time as something special while not putting pressure on either her or yourself.

 

[DixieWrecked]

and your total testosterone?

usually around 1200. No AI or hCG

try a different manufacturer of cialis. Also make sure it’s not from India. Prasco labs (USA) makes an authorized generic of cialis. Teva pharmaceuticals from Israel is ok too. You may have to look up the distributor and manufacturer. In addition, try taking a low dose daily whether in am or pm it broken up in 2 doses for both am and pm so it stays in your system. Then on the days it’s on, take an extra one. ED drugs lose potency After you work out too. Cialis is known to aid in testosterone levels And helps give a great pump in workouts. So on hard workout days you may need an extra dose.
I take a daily 5mg on empty stomach and don’t eat at least 1 hour afterward to make sure it’s absorbs. On days i lift or exercise much harder I throw in an extra one afterwards or at night.

All good feedback. I am actually going to contact my pharmacy today and see where they procure from. Interesting about the physical activity. Is the potency loss something you have personally noticed or is that common?

Tadalafil is also used to treat pulmonary hypertension (PAH) under the trade name Adcirca. In this manner the usual starting dose is 40mg daily, and titrated up to 60mg (20 mg TID) depending on the response. You really have to be conscious of the nitrate interaction, or you’ll be found unconscious. Tadalafil - Pulmonary Hypertension Association

Also very good to know. These guys must be walking around with aching hard-ons with that treatment.

 

[DixieWrecked]

IS there a particular pharmacy that generally carries American Made generics? Costco?

 

[Golfboy307]

Totally agree MM: older guys like us with long term marriages, there are a lot of psychological and nerve factors that affect performance day to day. (As opposed to in our teens and 20's).

 

[charile12]

I take 5mg cialis daily. It works. On the weekend I take an extra 5 and it works really well.

What am trying now is taking the 5 cialis with a 20mg Viagra. Works very good. I think the Viagra lowers sensitivity a bit.

Or should I just go for 10 daily?

 

[Cooper]

All - I have been only having limited success with Cialis daily 5mg. My Dr gave my Viagra 100mg to supplement with on actual days when I would be having sex. I have not tried the Viagra yet because I have read all the descriptions about Blue Vision due to Viagra. Do I need to be concerned about this? Have any of you had an issue taking Viagra? Also have you found Viagra to be more effective than Cialis?

 

[charile12]

All - I have been only having limited success with Cialis daily 5mg. My Dr gave my Viagra 100mg to supplement with on actual days when I would be having sex. I have not tried the Viagra yet because I have read all the descriptions about Blue Vision due to Viagra. Do I need to be concerned about this? Have any of you had an issue taking Viagra? Also have you found Viagra to be more effective than Cialis?

You may want to try 10mg cialis first. Did you try taking 10mg and see a difference?

 

[Vince]

All - I have been only having limited success with Cialis daily 5mg. My Dr gave my Viagra 100mg to supplement with on actual days when I would be having sex. I have not tried the Viagra yet because I have read all the descriptions about Blue Vision due to Viagra. Do I need to be concerned about this? Have any of you had an issue taking Viagra? Also have you found Viagra to be more effective than Cialis?

I've never had any issues with using Viagra. I do know some people that get blue vision, but I never have. Most people I talk to and that includes me, believe that Viagra works better than Cialis. I think you should try them.

 

[sammmy]

If generic rx Cialis is not working, try to chew the tablet to a fine paste. Most generic manufacturers do not test the delivery formula and in some cases it just doesn't deliver the drug. I've had such a case with generic Ambien - it works only if I chew the tablet, otherwise zero effect.

 

[Cooper]

If generic rx Cialis is not working, try to chew the tablet to a fine paste. Most generic manufacturers do not test the delivery formula and in some cases it just doesn't deliver the drug. I've had such a case with generic Ambien - it works only if I chew the tablet, otherwise zero effect.

Mine are actually capsules from Empower Pharmacy

 

[BuzzSaw]

I'm 47 years old, and take 25mg generic viagra daily. It def helps in the bedroom department. Been on TRT for about 3 years, and errections were still bad, so it's probably down to clogged arteries, etc (I've had high cholesterol for years, so changing my diet to mostly vegan).
There are other health benefits to taking a small daily dose of the blue pill, so will carry on taking it.

 

[DixieWrecked]

I'm 47 years old, and take 25mg generic viagra daily. It def helps in the bedroom department. Been on TRT for about 3 years, and errections were still bad, so it's probably down to clogged arteries, etc (I've had high cholesterol for years, so changing my diet to mostly vegan).
There are other health benefits to taking a small daily dose of the blue pill, so will carry on taking it.

What time do you take your viagra? How do you time that?

 

[BuzzSaw]

In the morning after breakfast.

 

[DixieWrecked]

In the morning after breakfast.

and you can feel its effects into the evening?

 

[BuzzSaw]

Pretty much, yes. Kinda surprised for such a small dosage, plus it helps when working out as more pumped. You can also look up re health benefits of small dose Viagra, so there are other pluses to taking it.

 

[DixieWrecked]

Thanks for answering all these questions! How long have you been doing this?