Carpal tunnel symptoms and peptides

[mcs]

Anybody experience carpal tunnel syndrome symptoms (i.e. numbness in index finger, thumb and middle fingers) and body aches from GH peptides (tesamorelin, ipamorelin, etc.) especially when waking? I understand that CTS is a very common side effect with GH itself. What did you do to remedy it?

I had been using Ipamorelin/CJC-1295 blend 300mcg in a.m. and Tesamorelin 2mg + Ipamorelin 300mcg before bed daily to speed up healing and fat loss. The fat loss is gradual, but visible while lean body mass has likely increased as I feel "tighter" and my strength has started to increase. I also am using AOD-9604 and started Frag 196-191. I stopped for a few days to see of the symptoms will subside.

 

[Deleted member 43589]

YES. All of these peptides you mention increase GH levels, very similar to the way hGH does. What do you do? Lower the dose and then slowly go up.

Exogenous hGH and peptides can cause carpal tunnel syndrome is by increasing fluid retention in the body. This can lead to swelling and inflammation in the wrist and hand, which can also compress the median nerve and cause symptoms of carpal tunnel syndrome. It might be that by reducing or controlling the amount of fluid retention in the body you can relieve some of the pain in the wrists.

Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure

Abstract. Initiation of GH treatment in adults is frequently complicated by the development of symptomatic fluid retention. To investigate the mechanism and ext

academic.oup.com

Blockade of the renin-angiotensin-aldosterone system prevents growth hormone-induced fluid retention in humans - PubMed

To test if the renin-angiotensin-aldosterone system (RAAS) is involved in growth hormone (GH)-associated fluid retention, we examined the effect of GH administration in the presence or absence of RAAS blockade at different levels on body fluid homeostasis. Eight subjects were examined in a...

pubmed.ncbi.nlm.nih.gov

Thus, it may be possible to reduce some of this water retention by taking an angiotensin II receptor antagonist.

 

[mcs]

YES. All of these peptides you mention increase GH levels, very similar to the way hGH does. What do you do? Lower the dose and then slowly go up.

Exogenous hGH and peptides can cause carpal tunnel syndrome is by increasing fluid retention in the body. This can lead to swelling and inflammation in the wrist and hand, which can also compress the median nerve and cause symptoms of carpal tunnel syndrome. It might be that by reducing or controlling the amount of fluid retention in the body you can relieve some of the pain in the wrists.

Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure

Abstract. Initiation of GH treatment in adults is frequently complicated by the development of symptomatic fluid retention. To investigate the mechanism and ext

academic.oup.com

Blockade of the renin-angiotensin-aldosterone system prevents growth hormone-induced fluid retention in humans - PubMed

To test if the renin-angiotensin-aldosterone system (RAAS) is involved in growth hormone (GH)-associated fluid retention, we examined the effect of GH administration in the presence or absence of RAAS blockade at different levels on body fluid homeostasis. Eight subjects were examined in a...

pubmed.ncbi.nlm.nih.gov

Thus, it may be possible to reduce some of this water retention by taking an angiotensin II receptor antagonist.

I'm already taking Telmisartan and it still ddn't subside. Strange.

 

[Deleted member 43589]

Try to back off on the dose. If you are doing for instance 100mcg, drop down to 50mcg.

 

[mcs]

Update:

Cycled off the GH secretagogue peptides for about a week (continued with BPC-157, TB-500).

Not only is the carpal tunnel continuing to be an issue, but my existing trigger finger got much worse as well and has spread to my other digits and even thumbs which I never had a problem with before.

Prior post:

TRIGGER FINGER is OUT OF HAND (no pun intended)

Prior post: https://www.excelmale.com/forum/threads/anyone-have-experience-with-trigger-finger.21215/#post-180384 The warning signs started in 2019. Had first surgery in 2020. Thought it was a one and done. 3 years later and I am plagued with the worst trigger finger and pain in the rest of my...

www.excelmale.com

Latest labs (significant elevation in IGF-1, Z score but not GH or GRH since starting the peptides):