Carpal tunnel symptoms and peptides

mcs · Mar 4, 2023

Anybody experience carpal tunnel syndrome symptoms (i.e. numbness in index finger, thumb and middle fingers) and body aches from GH peptides (tesamorelin, ipamorelin, etc.) especially when waking? I understand that CTS is a very common side effect with GH itself. What did you do to remedy it?

I had been using Ipamorelin/CJC-1295 blend 300mcg in a.m. and Tesamorelin 2mg + Ipamorelin 300mcg before bed daily to speed up healing and fat loss. The fat loss is gradual, but visible while lean body mass has likely increased as I feel "tighter" and my strength has started to increase. I also am using AOD-9604 and started Frag 196-191. I stopped for a few days to see of the symptoms will subside.

Deleted member 43589 · Mar 4, 2023

YES. All of these peptides you mention increase GH levels, very similar to the way hGH does. What do you do? Lower the dose and then slowly go up.

Exogenous hGH and peptides can cause carpal tunnel syndrome is by increasing fluid retention in the body. This can lead to swelling and inflammation in the wrist and hand, which can also compress the median nerve and cause symptoms of carpal tunnel syndrome. It might be that by reducing or controlling the amount of fluid retention in the body you can relieve some of the pain in the wrists.

Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure

Abstract. Initiation of GH treatment in adults is frequently complicated by the development of symptomatic fluid retention. To investigate the mechanism and ext

academic.oup.com

Blockade of the renin-angiotensin-aldosterone system prevents growth hormone-induced fluid retention in humans - PubMed

To test if the renin-angiotensin-aldosterone system (RAAS) is involved in growth hormone (GH)-associated fluid retention, we examined the effect of GH administration in the presence or absence of RAAS blockade at different levels on body fluid homeostasis. Eight subjects were examined in a...

pubmed.ncbi.nlm.nih.gov

Thus, it may be possible to reduce some of this water retention by taking an angiotensin II receptor antagonist.

mcs · Mar 4, 2023

BigTex said:
YES. All of these peptides you mention increase GH levels, very similar to the way hGH does. What do you do? Lower the dose and then slowly go up.

Exogenous hGH and peptides can cause carpal tunnel syndrome is by increasing fluid retention in the body. This can lead to swelling and inflammation in the wrist and hand, which can also compress the median nerve and cause symptoms of carpal tunnel syndrome. It might be that by reducing or controlling the amount of fluid retention in the body you can relieve some of the pain in the wrists.

Short-term growth hormone (GH) treatment of GH-deficient adults increases body sodium and extracellular water, but not blood pressure

Abstract. Initiation of GH treatment in adults is frequently complicated by the development of symptomatic fluid retention. To investigate the mechanism and ext

academic.oup.com

Blockade of the renin-angiotensin-aldosterone system prevents growth hormone-induced fluid retention in humans - PubMed

To test if the renin-angiotensin-aldosterone system (RAAS) is involved in growth hormone (GH)-associated fluid retention, we examined the effect of GH administration in the presence or absence of RAAS blockade at different levels on body fluid homeostasis. Eight subjects were examined in a...

pubmed.ncbi.nlm.nih.gov

Thus, it may be possible to reduce some of this water retention by taking an angiotensin II receptor antagonist.

I'm already taking Telmisartan and it still ddn't subside. Strange.

Deleted member 43589 · Mar 4, 2023

Try to back off on the dose. If you are doing for instance 100mcg, drop down to 50mcg.

mcs · May 8, 2023

Update:

Cycled off the GH secretagogue peptides for about a week (continued with BPC-157, TB-500).

Not only is the carpal tunnel continuing to be an issue, but my existing trigger finger got much worse as well and has spread to my other digits and even thumbs which I never had a problem with before.

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