B12 Injection SubQ

[sammmy]

And here are reviews that say it works for pernicious anemia:

Amazon.com

 

[Deleted member 16042]

And here are reviews that say it works for pernicious anemia:

Amazon.com

Thanks, that's great. If it is true, I am all for it, but I don't make medical decisions based on Amazon reviews. Show me clinical data. I would truly like to see it!

Ah crap, I'd even be willing to try this stuff if I need B-12 again, but the additives are a no go. I've gotten whalloped by a couple supplements when I forgot to check the ingredients closely.

 

[sammmy]

Even if assuming a meager 1% absorption, 2 tabs of Kirkland (10 000 mcg) will instantly get in your blood stream 100mcg B12, which is the dose in the daily injections for anemia. I suggest letting it dissolve in mouth for 10 mins before swallowing, although I just chew them like candy and it still works for me. There are reviews claiming that the daily tabs give them higher levels than the monthly shots (I'm assuming the monthly 1000mcg).

There might be outliers that do not absorb the tabs enough and need injections. The only way to test that is to try it. If you wait for "clinical data", it will never come.

 

[Deleted member 16042]

Even if assuming a meager 1% absorption, 2 tabs of Kirkland (10 000 mcg) will instantly get in your blood stream 100mcg B12, which is the dose in the daily injections for anemia. I suggest letting it dissolve in mouth for 10 mins before swallowing, although I just chew them like candy and it still works for me. There are reviews claiming that the daily tabs give them higher levels than the monthly shots (I'm assuming the monthly 1000mcg).

There might be outliers that do not absorb the tabs enough and need injections. The only way to test that is to try it. If you wait for "clinical data", it will never come.

Your logic is reasonable, thanks.

 

[GreenMachineX]

Injections of B12 are not necessary. I take 5000mcg = 5mg Methylcobalamin quick dissolve tablets by Kirkland. If taken each day, these take me from low normal to twice the high normal blood level of B12. Nowadays I take these 1-2 times weekly. Never noticed any symptomatic change from those, but I was never actually deficient.

This is quite cheap, comes with 300 tabs, which will last forever. At much better price, this works just as well as the sublingual liquid preparations, which are astronomically overpriced.

For me, injections seem to be necessary. Between sublingual and quick dissolve my levels dropped from 500 to 362 over a few months, eating plenty of meat as well.

 

[sammmy]

It is all about using the correct formulation (they are not all the same), a high oral dose (about 1% is absorbed without any intrinsic factor so 2 x 5000mcg tablets will be the equivalent of a 100mcg daily injection), chew it in mouth and keep it under tongue for 10 mins then swallow.

Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route - PMC

To compare the efficacy of sublingual and oral administration of 500 µg of cobalamin in subjects with cobalamin deficiency. Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to ...

www.ncbi.nlm.nih.gov

Cobalamin (vitamin B12) deficiency is caused by pernicious anaemia, food–cobalamin malabsorption, vegetarianism, and other deficiency states. It has a reported prevalence of 3–29%[1]. The usual treatment for cobalamin deficiency consists of intramuscular injections of the drug. However, these can be painful, are difficult to give to disabled or elderly patients, and are costly if administered by health professionals [2]. In the 1960s, Swedish investigators treated 64 patients with pernicious anaemia with 1000 µg of oral cyanocobalamin, and all showed clinical and haematological remission [3]. About 1% of cobalamin is absorbed orally in subjects without intrinsic factor. The daily requirement of cobalamin is 1.0–2.5 µg, and thus, large oral doses may meet these needs [4]. This hypothesis was confirmed by several more recent trials with sublingual or oral doses of cobalamin between 1000 and 5000 µg [5–9].

Effective treatment of cobalamin deficiency with oral cobalamin - PubMed

Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or...

pubmed.ncbi.nlm.nih.gov

Oral Vitamin B12 Replacement for the Treatment of Pernicious Anemia - PMC

Many patients with pernicious anemia are treated with lifelong intramuscular (IM) vitamin B12 replacement. As early as the 1950s, there were studies suggesting that oral vitamin B12 replacement may provide adequate absorption. Nevertheless, oral ...

www.ncbi.nlm.nih.gov

 

[GreenMachineX]

It is all about using the correct formulation (they are not all the same), a high oral dose (about 1% is absorbed without any intrinsic factor so 2 x 5000mcg tablets will be the equivalent of a 100mcg daily injection), chew it in mouth and keep it under tongue for 10 mins then swallow.

Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route - PMC

To compare the efficacy of sublingual and oral administration of 500 µg of cobalamin in subjects with cobalamin deficiency. Thirty subjects with low serum concentrations of cobalamin participated in the study. Subjects were randomly allocated to ...

www.ncbi.nlm.nih.gov

Effective treatment of cobalamin deficiency with oral cobalamin - PubMed

Because cobalamin deficiency is routinely treated with parenteral cobalamin, we investigated the efficacy of oral therapy. We randomly assigned 38 newly diagnosed cobalamin deficient patients to receive cyanocobalamin as either 1 mg intramuscularly on days 1, 3, 7, 10, 14, 21, 30, 60, and 90 or...

pubmed.ncbi.nlm.nih.gov

Oral Vitamin B12 Replacement for the Treatment of Pernicious Anemia - PMC

Many patients with pernicious anemia are treated with lifelong intramuscular (IM) vitamin B12 replacement. As early as the 1950s, there were studies suggesting that oral vitamin B12 replacement may provide adequate absorption. Nevertheless, oral ...

www.ncbi.nlm.nih.gov

Well, that's why I'm doing both injections and pills now.