Anyone supplement E2 alongside TRT

[Gjohns28]

Not sure if I should start a new thread.....guess I'll post here first.

I'm also a low aromatiser and seemingly a low responder (T-985; E2-15 on 200 Test C per week) . I'm 2-weeks into supplementing Estradiol Cypionate (2mg per week) to try and change my t/e ratio.

Positives: EQ and erection frequency are up (nocturnal/morning) a lot; sensitivity is up a some (wasn't bad before); libido up a little (wasn't bad before); physically a lot stronger, more energetic; maybe a bit calmer/relaxed.

Negatives: My knees feel like someone inserted glass shards in them...as if I have low E2. Almost debilitating. Hurts to walk, impossible to do any type of athletics that require movement.

I guess I should give this more time/get blood work/etc....but not being in pain and being athletic are important to me. 3-4 more weeks of this feels like an eternity.

Note that my best T/E ratio was once at 600/35 and my joints felt like pillows. But this was with Enclomiphene....so libido was non-existent.

 

[Gjohns28]

I should mention...supplementing E2 was due to physically feeling weak/fatigued, brain fog, and joint pain (knees especially).

 

[Cataceous]

...
The main sexual dysfunction I have experienced is loss of sensitivity on my penis and I am wondering if I can get it back by increasing my estrogen. I just started HCG in the hopes of accomplishing this, did you have the same issue?

Anecdotally, some guys see improvements when reducing testosterone to more realistic levels. Even 80 mg TC/week combined with hCG is fairly high compared to what's natural. However, if my experience is also broadly applicable then the problem is not necessarily something that can be fixed by tweaking testosterone, estradiol and hCG. I believe the issue relates to TRT's disruption of other hormones. I made no headway until I started replacing upstream hormones in earnest. In particular, GnRH supplementation seems to be quite helpful. I've also been supplementing kisspeptin, oxytocin and progesterone. While sensitivity is nothing like teenage levels, the improvement is large in comparison to when I was on more generic TRT protocols.

 

[Gjohns28]

Anecdotally, some guys see improvements when reducing testosterone to more realistic levels. Even 80 mg TC/week combined with hCG is fairly high compared to what's natural. However, if my experience is also broadly applicable then the problem is not necessarily something that can be fixed by tweaking testosterone, estradiol and hCG. I believe the issue relates to TRT's disruption of other hormones. I made no headway until I started replacing upstream hormones in earnest. In particular, GnRH supplementation seems to be quite helpful. I've also been supplementing kisspeptin, oxytocin and progesterone. While sensitivity is nothing like teenage levels, the improvement is large in comparison to when I was on more generic TRT protocols.

Thank you! Lowering T was a thought I'd had and you've underscored it for me. Maybe shoot for that 600-700 level. I'm guessing that would be 120-130mg per week.

 

[Cataceous]

Thank you! Lowering T was a thought I'd had and you've underscored it for me. Maybe shoot for that 600-700 level. I'm guessing that would be 120-130mg per week.

What is your injection frequency and when to you test levels relative to injections? Physiological TRT doses are more like 40-90 mg TC per week in divided doses.

 

[Gjohns28]

Catacecous,

100mg every 3.5 days; testing at trough for levels. SHBG is around 50 so I thought it better to keep the frequency no more than twice a week. Got started at the standard telehealth 200mg per week and thought it may be too much. Then got labs and saw that it wasn't so high after all (in terms of Total/Free/E2).

Their solution to raise e2 was simply add more T but I'm not comfortable doing that. Like you, I feel like a borderline roid abuser @ 200mg. I've since left them as it didn't take me long to figure out they're a TRT-mill and I had become smarter than them after some time online.