A different dosing strategy with bremelanotide (PT-141) yields dramatically better results

[FunkOdyssey]

Probably better for another thread specifically on MIF-1, I'll make one soon in the Mental Health forum.

But I've done multiple cycles of it and each one is kinda different. The 1st one I did back in May I didn't even feel anything until like the 4th day when suddenly while at an outdoor mall I could feel that "vibe" again. This peak effect subsided but I still felt like my baseline was higher for some time until crashing later on for unrelated reasons.

No side effects. Its an amazing peptide for me. When I first did it though I started the first day at a smaller dose like 5 mg just to make sure no adverse effects. One might think "Oh because PT141 improves libido then MIF1 will lower it" but this is absolutely not true and in fact its a little the opposite because if anhedonia improves, libido improves for me anyways and MIF is dopaminergic after all (But I wouldn't expect it to improve libido for a non-anhedonic/blunted person)

I was feeling horribly numb in late August, I had crashed badly and I was getting very worried and in a dark place. I took MIF-1 and then within 2 hours felt it this last cycle. Suddenly the world was brighter, I felt a huge motivation and hedonic tone boost, could anticipate the future again, feel the sun out. This peak effect went down but I still came out of the cycle "reset" back to a copable point. It has a great effect on lowering stress-too. And while on it, the morning dread of the day (when my symptoms are worst) gets so much better.

It seems like I feel the effects earlier with each cycle. Know that MIF-1 the effects can actually go backwards if you take too much too long (this is mentioned in a study on the oral form), which is why its important to keep the schedule/dosing in accordance with that study. The longest I've done it is 8 mg for 8 days and when I did it on the 8th day things kinda went backward slightly. 5-7 days at most seemed ok for me. 6 days for me is the sweet spot. I believe its because it inhibits alpha-MSH and some is needed.

I did do bloodwork on my alpha-MSH before and at the end of one of my cycles though and it didn't go down that much just from 13 to 9.

Also I think MIF-1 should be used like a 'reset' opportunity. So literally exercise intense every single day you are on a cycle of MIF to make use of that dopamine to try to make it stick. Another thing I found is taking Mucuna Pruriens L-dopa supplement synergises with it (this is also in studies, MIF potentiates L-dopa).

LDN I stop while on MIF to avoid any interactions with opiod system (MIF-1 is kind of like a super LDN, its an opiod antagonist in ways I don't really get) , but afterwards, I notice my LDN endorphin rebound is stronger too for like a few days.

These days Ketamine IV is presented as the 'hot' thing for anhedonia but MIF1 was way way better for me.

Incredible post! Very valuable experience you've gained and shared. Yes, I agree this deserves its own thread. I took my first 10 mg dose today and don't feel much of anything yet. So far so good I guess.

 

[electrify]

I just started the thread here about MIF-1 MIF-1 (and other peptides) for Anhedonia/Depression

 

[Cataceous]

I think PT-141 (bremelanotide) is quite dangerous, years back in 2018 it sent me into a severe anhedonia episode at 200 mcg. ...

The dose makes the poison. That 200 mcg could still be tenfold more potent than your endogenous α-MSH. You should also investigate whether milligram-level doses of MIF-1 are similarly excessive.

Now that I'm further from the daily dosing experiments I am finding that even a single 20 mcg dose of bremelanotide taken every third day has an effect on libido, albeit a modest one.

 

[electrify]

The dose makes the poison. That 200 mcg could still be tenfold more potent than your endogenous α-MSH. You should also investigate whether milligram-level doses of MIF-1 are similarly excessive.

Now that I'm further from the daily dosing experiments I am finding that even a single 20 mcg dose of bremelanotide taken every third day has an effect on libido, albeit a modest one.

Yea based on your analysis it probably was an issue, which is surprising given that 200 mcg is still within the lower end of what is typically dosed. My MC4 receptors must have still been hypersensitive

I do need do check what endogenous levels of MIF1 are. I know that when I tested alpha MSH on bloodwork before and after was 13 and 9.

 

[Vince]

The dose makes the poison. That 200 mcg could still be tenfold more potent than your endogenous α-MSH. You should also investigate whether milligram-level doses of MIF-1 are similarly excessive.

Now that I'm further from the daily dosing experiments I am finding that even a single 20 mcg dose of bremelanotide taken every third day has an effect on libido, albeit a modest one.

Since it's a modest one could it just be a placebo?

 

[Bob62]

I can share my experience with pt141 1.5mg . Maximum consecutive daily use 2 days before tolerance develops. Minimum one week reset needed but even better one month. Perhaps some very mild anhedonia day 3and 4 after use but then rapid return to baseline mood. So for me it's a occasionally special treat use . Proerecttile but not prolibido for me. Btw I took a dose to sort out a booty call I wasn't that into tbh. All I can say is it's not that effective to do the job if you are doing a duty screw .

 

[Cataceous]

Since it's a modest one could it just be a placebo?

This can't be ruled out, as there's no blinding at the moment.

 

[Willyt]

The dose makes the poison. That 200 mcg could still be tenfold more potent than your endogenous α-MSH. You should also investigate whether milligram-level doses of MIF-1 are similarly excessive.

Now that I'm further from the daily dosing experiments I am finding that even a single 20 mcg dose of bremelanotide taken every third day has an effect on libido, albeit a modest one.

Did you experience any of the anhedonia/blunting that is being discussed as possible side effect?

 

[Cataceous]

Did you experience any of the anhedonia/blunting that is being discussed as possible side effect?

No, not in this trial, nor previously with several isolated "normal" doses of 1.5 mg.

 

[SoxsRocks]

This is interesting so some men have a little sexual desire so they use bremelanotide to get their libido back. It makes me wonder what makes them to lose it in the first place. I would think it's anxiety. Maybe if you got rid of your anxiety your libido would stay strong?

​

This is a great thread and definitely some good information that may benefit us all
Capacious that's some testing and I think I amngoing to actually follow that for myself.
My problem is slightly different Vince you ask how fo some men lose libido I never lost it it was taken away when I had prostate surgery (nerve sparing robotic prostatectomy) for cancer. Cialis/viagra no real help but Bremelanotide (pt-141) filled a gap, I purchased and tried it from reputable peptide companies until I had my primary Dr write a prescription to a compound pharmacy and honestly that worked better, morning wood, arousal and erection more frequently. Bremelanotide (pt-141) bridged the gap.
Now to test myself with Caragious work

Stay tuned

 

[FunkOdyssey]

This is a great thread and definitely some good information that may benefit us all
Capacious that's some testing and I think I amngoing to actually follow that for myself.

Now to test myself with Caragious work

I'm sure @Cataceous will appreciate the kind words after he recovers from the brutalization of his name.

 

[Vince]

This is a great thread and definitely some good information that may benefit us all
Capacious that's some testing and I think I amngoing to actually follow that for myself.
My problem is slightly different Vince you ask how fo some men lose libido I never lost it it was taken away when I had prostate surgery (nerve sparing robotic prostatectomy) for cancer. Cialis/viagra no real help but Bremelanotide (pt-141) filled a gap, I purchased and tried it from reputable peptide companies until I had my primary Dr write a prescription to a compound pharmacy and honestly that worked better, morning wood, arousal and erection more frequently. Bremelanotide (pt-141) bridged the gap.
Now to test myself with Caragious work

Stay tuned

I'm happy it's working for you and you have your love life back.

 

[zancek0]

This is a great thread and definitely some good information that may benefit us all
Capacious that's some testing and I think I amngoing to actually follow that for myself.
My problem is slightly different Vince you ask how fo some men lose libido I never lost it it was taken away when I had prostate surgery (nerve sparing robotic prostatectomy) for cancer. Cialis/viagra no real help but Bremelanotide (pt-141) filled a gap, I purchased and tried it from reputable peptide companies until I had my primary Dr write a prescription to a compound pharmacy and honestly that worked better, morning wood, arousal and erection more frequently. Bremelanotide (pt-141) bridged the gap.
Now to test myself with Caragious work

Stay tuned

This is interesting. So after the surgery you lost erections AND libido?
Do you perhaps remember what drugs/meds (if any) you were given prior to surgery?

 

[Golfboy307]

At my doctor appointment in September, he mentioned there is a new study out showing the positive effects of low daily dosing of PT141 versus the "on demand" high dose protocol. Similar benefits but much lower sides. I will see if I can get my hand on it and post here.

In the meantime, I had him call it in for me based on the lower dosing instructions. I will report back in due time.

 

[Wolverine]

At my doctor appointment in September, he mentioned there is a new study out showing the positive effects of low daily dosing of PT141 versus the "on demand" high dose protocol. Similar benefits but much lower sides. I will see if I can get my hand on it and post here.

In the meantime, I had him call it in for me based on the lower dosing instructions. I will report back in due time.

Thanks! What is your doc's low dosing regimen?

 

[Golfboy307]

We have communicated via his portal, so not totally sure. He said it would be in the prescription instructions. Will let the group know.

 

[nippy]

We have communicated via his portal, so not totally sure. He said it would be in the prescription instructions. Will let the group know.

Any news

 

[Golfboy307]

Sorry no info yet. Been so busy haven't been able to get going on the daily dosing program. Hope to give it a try once life calms down a bit.

 

[Vince]

I haven't seen an update to this thread for a while. I was wondering how you guys are doing with low libido and this protocol.

 

[Golfboy307]

I haven't started yet. Doing some year end shock wave sessions which really boost EQ for me. Not sure I want to do both at the same time. Will keep you posted.