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Still a ways off with the Phase 2A trial just getting started. If it continues to look good then it may show up on research chemical sites before FDA approval, depending on its legal status.

Natesto has the evidence behind it. It's the only form of TRT proven to allow continued HPTA function, which in my mind makes it more physiological. Oral forms cause more complete suppression unless accompanied by a SERM. It's likely that appropriately dosed buccal troches would be similar in...

It comes as 100 mg/mL, but I dilute it to 50 mg/mL for quarter-milligram dose resolution.

Suspensions are water-based. In this case there are micronized testosterone particles suspended in the carrier; being hydrophobic they do not dissolve as they would in oil. The injections are spaced six hours apart. No blood work yet, but I am seriously considering doing a sequence of tests to...

The slower the transition, the less the likelihood of side effects. If you limit the reduction to a few milligrams per week then you may not even notice it. But then it will take a few months to complete. With respect to anxiety, have you ever tested your serum progesterone? Frequently it is...

If your goal is primarily to be healthy then be aware that the maximum testosterone production in healthy young men is equivalent to 90-100 mg testosterone cypionate per week, and 60-70 mg is typical. By this standard you are vastly overdosed. The long-term consequences of this are uncertain. We...

Older men do get more "bang for the buck" from testosterone because the metabolic clearance rate declines with age. That is, free testosterone will typically go higher at the same dose as we age. There is no evidence that high levels of testosterone are healthier or to be preferred in any way...

I agree that estradiol is the stronger regulator, but we typically observe that enclomiphene fails to stimulate the HPTA under conventional TRT. This is most likely due to the direct negative feedback of androgens on kisspeptin neurons in the arcuate nucleus. I've suggested that using cistanche...

You have my sympathy. Having experienced something similar, I think people fail to appreciate the dramatic effects menopause can have on some women. It goes well beyond libido, perhaps affecting feelings of empathy and connectedness to significant others. Nominally my wife divorced me because I...

It might work in some healthy individuals, but it's more of a stretch for those suffering from secondary hypogonadism, who have a reduced natural set point for testosterone. A crude estimate based on an 18 hour half-life is that propionate still leads to a trough that's 40% of the peak. I...

Your one measurement is already more useful than any guesswork I might provide, especially if we assume a fair amount of individual variability. To me it says that lowering the dose to 150 IU hCG EOD has a decent chance of reducing suppression to the point where LH is at least low-normal.

Are you thinking that any potential return on their risky investment should be limited by your definition of fairness rather than by the free choices of buyers and sellers? That's been tried and it was a colossal failure.

That's highly dependent on the doses involved. DHT can inhibit aromatase, so at high enough levels there could be a noticeable effect on estradiol, but still nothing like a dedicated aromatase inhibitor. The dose of hCG also matters. At lower doses the HPTA may not be fully suppressed, implying...

I think it's more a matter of semantics. It is true that esters slow the release of testosterone, and that once released from the esters the testosterone molecules are indistinguishable from others, regardless of source. I do not believe @madman is arguing that differing pharmacokinetics do not...

At least in the past I recall that they used the ratio of testosterone to epitestosterone to reveal doping. It's stated that an abnormal T/E ratio can also be indicative of the use of exogenous DHT. Epitestosterone is an inactive epimer of testosterone that is naturally produced in equal...

Most men will have significant HPTA suppression with a TC/ENC protocol, making the enclomiphene not worthwhile. However, you can bypass the hypothalamus, where the significant negative androgenic feedback occurs, by injecting GnRH in pulses.[R] Another quibble is that 10-20 mg TC daily is hardly...

Equilibrium dialysis is supposed to be the gold standard. Therefore if the test was done correctly then the results point against SHBG causing the variation in testosterone; free testosterone appears to drop in proportion to total. This leaves lab error as the most plausible reason for the large...

Yes, impaired/slower metabolism leads to higher levels of testosterone, the opposite of what you're seeing. This is a good idea. It's useful to have SHBG so that you can calculate free testosterone from total using the Vermeulen method. The general expectation is for average free testosterone...

https://www.excelmale.com/threads/a-different-dosing-strategy-with-bremelanotide-pt-141-yields-dramatically-better-results.28542/

Nothing much happens to the testosterone, but carrier oils may degrade over time and be less healthy to inject. Underlying metabolism of testosterone is unlikely to change much in this time frame. It gradually slows with age, leading to higher testosterone at the same dose. In theory a...

It doesn't really support the assertion by @aneuman of no suppression below 5 mg exogenous T per day. FSH levels in 17 of 18 individuals receiving at least 5 mg testosterone per day were at or below prepubertal levels (4.59± 0.17) (13) ... At no time were levels of LH and FSH higher after...

Due to individual variation there's no fixed answer. In switching to injections you will likely produce less DHT, which could be helpful. But it's also easier to attain very high testosterone levels with injections, which could be counterproductive. Your best bet is to start injections with a...

It seems likely to be true, especially if you stipulate similar LH/hCG activity. But a comparison between endogenous LH and exogenous hCG isn't exactly straightforward.

Is this figure based on any rigorous accounting? But assuming it is correct, perhaps it matches the fraction who didn't bother to monitor serum levels and titrate the dose accordingly. The supposedly low topical progesterone dose of 10 mg per day yields 1 mg absorbed per day at 10% efficiency...

On the plus side, I think the article helps to emphasize the importance of achieving and maintaining a good balance between progesterone, testosterone, DHT and estradiol. On the minus side, promoting a progesterone product on the same page does somewhat diminish its credibility.

Thanks for the added information. In my understanding, progesterone isn't essential for her both because there's no uterus to respond to estradiol and because the vaginal cream has limited systemic activity. It's different for women with a uterus starting systemic HRT, and I'm curious about how...

Yes, 5 mg per week isn't a bad starting point, ideally in divided doses. That translates to 0.5 mg of testosterone per day, which is perhaps a little high relative to natural production, with various sources suggesting 0.1-0.4 mg. It's possible that adding testosterone will also increase...

Blending propionate with a longer ester such as cypionate or enanthate is a good choice if you're going to inject daily. Propionate alone causes an unnaturally large variation in serum testosterone, while a longer ester usually leads to an unnaturally low variation. There's a long thread here...

If you're US-based and in the right state then you can support the site sponsor: https://www.discountedlabs.com/free-estradiol-sensitive Alternatively, free estradiol can be estimated with a calculator: https://www.excelmale.com/threads/spreadsheet-for-calculating-free-t-e2.17216/

That's not what he said. He said that changing SHBG is not going to change free testosterone, only total. It's great to see a doctor who understands this.

Disagree. I counter your anecdote with my own. I do better on lower doses and I have actually tried a wide range of physiological doses..