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Any updates to your low dose protocol? Do you inject subq or shallow IM?

We’re talking about anything in large quantities being somewhere in the body where you wouldn’t typically see large quantities of said substance: hundreds of milligrams of T or TU 2x/day in the lymphatics. It’s just a personal concern of mine. I have no evidence to support T or TU in the...

Pinched abdominal skin and love handles.

The Natesto applicator found its way back into my nasal vestibules (home). I’ve had a couple great days now in a row. I’ve also made a point to include more cow flesh. No promises but if I can stave off the jelly nose fatigue I may just hold off on pulling labs for a while and assess based...

Generally speaking, there is a direct relationship between SHBG and metabolic health… particularly in the liver where SHBG is produced. Low SHBG is generally a consequence of poor metabolic health. Testosterone can improve metabolic health for some so in those cases SHBG could rise slightly...

I’ve got a few concerns with the new orals. For one we just don’t have the long term use data. What does hundreds of milligrams of TU in the lymphatics do if anything good or bad? What about excreting 10% via the intestines? My biggest concerns involve ingesting the “other ingredients” over...

Thanks buddy! Gotta love the Decepticons and yes I still have the sense of humor of a 5 year old so… Based on the research I have done, I’m targeting a ferritin of 100 ng/ml. Anything below 50 can be problematic. I’ve experienced restless leg, Koilonychia, extreme fatigue, itching without a...

n of 1 but… on subq my E2 was higher, T lower, I retained more water, and I experienced less symptomatic improvement compared to the same dose injecting shallow IM with a 27 G 1/2” My HCT was 1 point lower on subq 49 vs 50 with shallow IM

Agree, agree, agree! It’s really hard to pull a 370 on Natesto and not conclude that you’re undertreated despite feeling pretty good thanks to the endless messsging on every corner that T numbers are everything! I know it’s the reason I’ve bailed on Natesto more times than I’d like to admit. I...

Well I wouldn’t necessarily compare those swings to the diurnal swings in endogenous production from a symptomology perspective because we’re talking about two different systems… one fed by endogenous production and the other by exogenous through a mucous membrane 3x/day. Def think it’s helpful...

From what I’ve gathered, it’s the peaks that facilitate the symptomatic improvements. It’s looking more and more like it’s the chronically high troughs that are responsible for the side effects we all come on to these forums to complain about. You pulled some great numbers on Natesto! If I...

We’ve had very similar experiences! I’m a long time TRTer (15 years). My ferritin has been chronically low for years and it’s been challenging to raise it while on T. Every time I’m on low dose injections my HG/HCT creeps up to the >17/>50 range. My HG/HCT is perfectly normal off T. I tried to...

How long after dosing Natesto did you get your blood draw for that 932 ng/dl? Were you doing anything different with the administration?

What do your hemoglobin and hematocrit numbers look like on daily injections vs your previous protocol frequency?

Would be helpful to know when you administered Natesto in relation to your blood draw because it’s in/out so quickly. No free T measure?

Great share! When are you dosing testosterone cypionate in relation to your current HCG regiment?

Happy to dialog with a fellow Natesto-er. One thing to keep in mind as you chew on next steps. Judging from your LH/FSH, you’re currently not suppressed and recovering from suppression can take some time as I’m sure you’re aware. I believe a fully functioning HPTA is critical if you hope to have...

It may be worth experimenting with dosing per the instructions. Clearly it’s possible for some to see a substantial peak 1 hour after dosing as evidenced by the trial data. As for SHBG, not sure what your diet is like but low carb diets/fasting tends to raise SHBG. On paper, I still believe...

When was the blood draw in relation to dosing? As far as application, do you paint it on with the applicator or do you follow the insert instructions: dispense and gently massage? Looks similar to the results I’ve gotten. I’ve never pulled anything higher than a 470 ng/dl and I’ve pulled labs...

Roger that. Thank you for sharing. Hopefully my SHBG will rise to a somewhat more respectable level with some additional time under my belt. That said, the 11 I scored was a snapshot and it occurred when my t was maxed out so no telling where it is once T drops off… likely increases...

The overarching point of my post revolved around dosing without food/meal. I believe you (systemlord) mentioned once that you were trying that. Are you… any lab work? If you’re on the 316mg dose you don’t have the option to drop to 237mg. Like I mentioned the 316mg dose consists of (2) 158mg...

I've followed Systemlord's progress with Jatenzo. After being on TRT for well over a decade and countless complications from injections, dealing with discontinued products like Androderm or a complete lack of therapeutic effectiveness from alternate modalities like Natesto, I decided to give...

Your labs mirror mine pre-TRT, similar age when I started, same height... you got me on weight ;) If you and your doctor decide to pursue treatment via TRT - my advice since you asked... 1. Never change but one variable at a time!!! I do not recommend jumping into TRT with T, HCG and an AI...

I believe the half life is 60 hours! Mind if I ask what your latest prolactin lab was Loki? Saya knows his stuff no doubt!

There are suggestions that high E2 can lead to high prolactin in some cases and yes... high prolactin symptoms mirror many of the same symptoms associated with high E2. High prolactin (in the 20s and above) will kill erections in most guys. Prolactin naturally rises after orgasm... makes you...

Vince - may have missed it... are you injecting SQ, IM or shallow IM?

BTW Coast... the needles you use are 1/2" correct? What are your preferred injection sites?

It is my belief that anytime the body senses a sudden influx/rise in testosterone (a peak) the body responds by taking measures to bind up and metabolize what it considers excess in an attempt to reach homeostasis (genetically/receptor mediated of course). I also believe that due to genetic...

Also... Dr. Saya did not think my SHBG of 37 precluded me from ED injections as the goal is to minimize the T peak and thus conversion to E2.

Here's an update following my discussion with Dr. Saya. As I stated, like CoastWatcher, I'm looking to avoid having to rely on an AI to manage my E2. Dr. Saya is aware of this. He also agreed it was logical at this point to work with one variable at at time so for the next 8 weeks, I'll...