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I would test first before you decrease your dose. Perhaps the 20mg are working well and levels are not too high. The usual dose of oral progesterone for men is 5/10mg, I'm sure some may need more, or less. I believe there is a U shape curve with pretty much anything, Progesterone helps with...

low cortisol/aldosterone did not affect TRT for me. But TRT can certainly exacerbate an existing adrenal/thyroid issue, especially when supraphysiologic doses are used for long period of time.

I would test progesterone if I were you, just making sure you are not going to high with it. 20mg orally is a pretty high dose

What do you guys think of AutoSleep app for Apple Watch? Has anyone tried this app? I think it works better than the integrated Apple Watch tracker

Do you know your Pregnenolone/Progesterone levels? FT4/FT3 rT3 numbers?

do you know what is your Progesterone level?

What time is your supper?

Pregnenolone-S has a half life of 16/8 hr, so it may not make sense to take it once per week unless a bigger dose is taken. A smaller dose like 25/50mg daily makes more sense to me.

Ok, adrenal heath is the foundation of HRT, if you are low in adrenal hormones other things won’t work well. Test also the aldosterone, low aldosterone may cause racing heart as well. Low cartisol can promote higher levels of adrenaline which can cause increased heart rate at times. But some...

If you have history of TBI you definitely want to test Pregnenolone, Progesterone, DHEA, cortisol, IGF-1, on top of Testosterone and Thyroid. 200mg test per week may make you feel good in the short term, but it may also create more problem with the brain later on. Starting at 100mg in divided...

Have you looked at your Aldosterone and cortisol level? How is your FT4\FT3?

what dosages have you been using of TRT?.

@DS3 curious to know what’s your progesterone level is with 5mg orally.

Abstract Tryptophan administration was used to evaluate the possibility that serotonergic neurons are involved in regulating the release of cortisol, renin, and aldosterone. Eleven studies were undertaken using 2 or 10 g tryptophan administered to fasting patients in continued supine posture...

That’s interesting to see how many have reported building tolerance to it plus addiction. A doc in the HRT space a couple of years ago RX it to me and said there was no addiction to it, good thing I use it once in a while

Curious to know your DHT and E2 level with the 1 click transcrotal cream

do you believe you have less issues with smaller Test dosages like the 42mg per week? are you monitoring also Pregnenolone/Progesterone/DHEA/Cortisol/Thyroid? what type of diet are you eating?

Curious to know what have been your dosages and frequency of TRT?

Understood, as always thanks for the well thorough explanation.

@Cataceous I was reading some comments of yours in another thread. It was mentioned that considering the physiologic testosterone production, because naturally Testosterone fluctuates during the day, when on TRT we should account for a 20 to 30% more. why is that?

@Anonymon any thoughts here?

thanks for attaching this! I appreciate it.

I have seen @Cataceous writing this over and over, but recently watched a couple of videos were it was also mentioned how much testosterone a man naturally produce. High HCT? acne? water retention? anxiety/restless, they may be all side effects of supraphysiologic Test dosing. Andrew...

we both take 1 grain in the am and 1 grain at about 3/4PM, blood was drawn at about 10 am. My GF does not show any hyper symptoms at all. She can now tolerate the cold, doesn't feel sleepy in the PM and sleep better at night. My self, i started to feel much less cold hands feet at the 4 weeks...

I was surprised to see these results, as based on Stop The Thyroid Madness, I really thought optimal would be achieved with over two grains. I wasn’t able to hold the dose for a full month before labs due to traveling, but actually a bit less than 4 weeks. My GF also on the same dose, but held...

I’m not sure Pharmacies can still compound NDT, I think there is some new regulation about it. What I meant is that, they can coumpaund a synthetic T4/T3 with same NDT ratio.

Compounding pharmacies like Empower, can compound the equivalent of a NDT grain in a T4/T3 combo. I’m wondering if they can compound also T2/T1 and calcitonin with it.

Pregnenolone in order to convert to Progesterone/allopregnenolone needs to make the first pass in the liver. If you search in the forum under Pregnenolone, you will find the studies plus a discussion about it.

Beside the sleep, have you experienced increased anxiety and memory loss as well after TRT? I’m sure you know oral micronized Pregnenolone converts into Progesterone.

Is your Progesterone low also?

normalizing DHEA-s levels can also improve penis sensitivity