AIs and E2 from HCG

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skullmaggots

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I'll keep this simple, but I've read all sorts of things on this. Can the E2 increase experienced from adding HCG to your TRT be controlled via an AI? If not, then how an earth does anyone take HCG? My e2 shot up fom 35pg/mL to approx 80pg/mL. This has lead to an increase in libido but a decrease in my ability to get or maintain an erection.

I am doing bloods, and second test is tomorrow. At the moment I'm taking 15mg exemestane a week.
 
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I haven't seen a definitive answer to this, but I'll give you my take. Competitive inhibitors such as anastrozole may be less effective in the intratesticular environment, where testosterone concentrations are very high and hCG is acutely stimulating aromatase activity in Leydig cells. My guess is that suicide inhibitors such as exemestane are less susceptible to these factors; as soon as an exemestane molecule binds to an aromatase molecule it's game over for the aromatase.

I think systemically you'll able to knock down estradiol with a high enough dose of either type of AI. Whether this is wise is another question. There is at least the theoretical possibility of creating localized estrogen deprivation, even when serum levels appear to be ok.
 
skullmaggots said:
I'll keep this simple, but I've read all sorts of things on this. Can the E2 increase experienced from adding HCG to your TRT be controlled via an AI? If not, then how an earth does anyone take HCG? My e2 shot up fom 35pg/mL to approx 80pg/mL. This has lead to an increase in libido but a decrease in my ability to get or maintain an erection.

I am doing bloods, and second test is tomorrow. At the moment I'm taking 15mg exemestane a week.
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Someone's opinion, experience. Maybe it is helpful to you.


I would reduce the hcg dosage and question if I really need hcg.
 
skullmaggots said:
Can the E2 increase experienced from adding HCG to your TRT be controlled via an AI?
Click to expand...
You will not find definitive answers when dealing with "individuals" unique biology processes.

AI's can't affect E2 produced inside the testicles and I recall a few members who couldn't bering down E2 using an AI while on hCG.
 
Thought I'd post my second week blood results my E2 is now 27pg/mL this is down from 80pg/mL so I can say that Exemestane has lowered my E2 serum levels. Obviously I will need to work out whether this will result in a crash when I get a moment. Gut feel is I need to back off a little and monitor every 2 weeks to see if my E2 becomes stable. I estimate about 7-10mg Exemestane a week for 500iu*2 HCG and 50mg * 3 Cyp.
 
skullmaggots said:
Thought I'd post my second week blood results my E2 is now 27pg/mL this is down from 80pg/mL so I can say that Exemestane has lowered my E2 serum levels. Obviously I will need to work out whether this will result in a crash when I get a moment. Gut feel is I need to back off a little and monitor every 2 weeks to see if my E2 becomes stable. I estimate about 7-10mg Exemestane a week for 500iu*2 HCG and 50mg * 3 Cyp.
Click to expand...
From 80 to 27 with only 15mg exemestane. You must be a hyper responder. Great that it works. Do you feel any different now?
 
I think the big swing in my E2 initially caused a drop in my libido/EQ. However, last night after some Viagra had some pretty decent sex. My libido is also coming back in waves, I feel more confident and alpha if that makes sense. I'm also taking 20mg ED of proviron which I know can reduce E2 a little, never done that much before for me but sure it contributed a little bit. Now, whether the blood level of E2 is a reliable proxy for tissue level E2 is another question, but it's all we've got to go on atm.
 
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This is from AI review.
Injecting HCG into the scrotum could cause pain, irritation, and potential tissue damage.
 
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