KYZATREX (oral testosterone undecanoate) now available in all states across the US

Ravenouz said:

Did you get any nasty side effects by the way?

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Ravenouz said:

I am looking at all the warnings and one of them says increase risk of death.

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Jcilla said:

Does anyone have the study with oral T where the doctor talks about taking the second dose early afternoon?

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madman said:

There is no study using such dosing (early am/early afternoon) protocol.

Some uros especially Dr. Sun recommend such dosing protocol for some of their patients in order to maximize T levels during the day which would allow one to avoid the peak that would be achieved in the late evening after the second dose as some men may feel too amped up which can cause numerous issues for some especially when it comes to getting quality sleep.

I already posted the link for the interview with Dr. Sun in post #28 of this thread.


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Systemlord said:

I'm on Jatenzo @237 mg twice daily. I have libido and erections, not so on injections after a couple of weeks. The rapid and frequent spikes in hormones I believe is the reason for optimal response.

When on injections, I don't feel the anabolic effects even with similar hormone levels.

The other day I tested testosterone at 4 pm, 3 hours past my midpoint. I was still in the 400 range, having spent the morning and mid afternoon with testosterone at the top end of the ranges.

Jatenzo is the only formulation of TRT that has worked for me!

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Ravenouz said:

Amazon Pharmacy: CLARUS THERAPEUTICS JATENZO 237 MG CAPSULE (1 Capsule)

Amazon is showing a 30 day suppy is 600$. Thats seems sky high. I dont have any insurance, any other source? I called my doc and it will take 20 days for a new appointment after i missed my appointment call today....why is this 20x the price of normal testosterone?

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Oral TU- IT’S GO TIME - HELPING YOU GET STARTED ON JATENZO®

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Can't get it up... Ferritin that is. Blood issues after 5 years. HCG related question. Labs attached.

I have been on TC for over 5 years with varying results, mostly positive until the last year. I have had to do a few blood donations within the last 3 years due to rising HCT. It dropped my ferritin levels to 10, range 30 - 400. I can't get my ferritin levels up. My Mayo PCP said that if I take...

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Kyzatrex or Jatenzo

Good day all. I've been on testosterone cypionate almost 7 years. I inject anywhere from 100 to 120 mg in total divided 2 times a week. Am 47. I'm feeling good consistently for years now. Looks like my insurance cover oral testosterone. I did read some threads on here, I see system Lord is...

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madman said:

Possible dose titration (Jatenzo or Kyzatrex) needs to be kept in mind when it comes to the cost as not everyone will fare well or hit a high enough T level with the starting doses.

A phase III, single-arm, 6-month trial of a wide-dose range oral TU (Kyzatrex) product

Abstract Background Oral testosterone undecanoate (TU) formulations may provide effective, safe, and easily titratable testosterone replacement therapy. Objective Demonstrate efficacy and safety of a novel oral TU formulation. Design An open-label, single-arm, multi-center trial treated...

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Dose and impact of baseline characteristics.

The distribution of final doses is provided in Figure 3. The logistic regression analysis of the impact of baseline characteristics on final dose demonstrated that body weight and diabetic status were positively associated with higher final dose (⩽400, 600, or 800mg) with odds ratios of 3.928 (95% CI: 1.896–8.137) and 2.646 (95% CI: 1.111–6.300), respectively. In contrast, use of antihypertensive medication had no influence on final dose.


Figure 3. Final dose distributions after 90 days of treatment with KYZATREX
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ORAL TU (316 MG BID) QUICKLY AND EFFECTIVELY INCREASES SERUM T CONCENTRATIONS IN HYPOGONADAL MEN

INTRODUCTION AND OBJECTIVE Over 2.4 million US men have hypogonadism, defined as serum testosterone (T) levels

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*Overall, 316 mg TU BID quickly and effectively increased serum T concentrations above 450 ng/dL in 77% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 23% <450 ng/dL and 27% 1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.





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Oral TU Quickly and Effectively Achieves Serum Testosterone ≥300 NG/DL in Most Hypogonadal Men Without Dose Titrations

* Overall, the starting dose of 237 mg TU BID quickly and effectively increased serum T concentrations ≥300 ng/dL in 85% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 15%

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Conclusions:

Overall, the starting dose of 237 mg TU BID quickly and effectively increased serum T concentrations ≥300 ng/dL in 85% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 15% <300 ng/d and 12% ≥1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Therefore, an oral T replacement therapy that allows for dose titration would likely be preferable to a fixed dose. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.