Systemlord
Member
None.
That's a load of sh**! There's an increase risk of death living life, like crossing the street. There's increase risk of death with any other medicines.
KYZATREX (oral testosterone undecanoate) now available in all states across the US
- Thread starter madman
- Start date
madman
Super Moderator
There is no study using such dosing (early am/early afternoon) protocol.
Some uros especially Dr. Sun recommend such dosing protocol for some of their patients in order to maximize T levels during the day which would allow one to avoid the peak that would be achieved in the late evening after the second dose as some men may feel too amped up which can cause numerous issues for some especially when it comes to getting quality sleep.
I already posted the link for the interview with Dr. Sun in post #28 of this thread.
Thanks I knew I saw it somewhere! Do you have any experience with this dosing schedule?
Amazon Pharmacy: CLARUS THERAPEUTICS JATENZO 237 MG CAPSULE (1 Capsule)
Amazon is showing a 30 day suppy is 600$. Thats seems sky high. I dont have any insurance, any other source? I called my doc and it will take 20 days for a new appointment after i missed my appointment call today....why is this 20x the price of normal testosterone?
Amazon is showing a 30 day suppy is 600$. Thats seems sky high. I dont have any insurance, any other source? I called my doc and it will take 20 days for a new appointment after i missed my appointment call today....why is this 20x the price of normal testosterone?
madman
Super Moderator
Taking advantage here!
Forget amazon.
Things have recently changed here when it comes to the $$$ Jatenzo.
As I stated in a previous thread the cost for Jatenzo is absurd and luckily they were forced to offer a pay-out-of-pocket option recently due to trying to stay competitive with Kyzatrex and Tlando which already offered such.
Oral TU- IT’S GO TIME - HELPING YOU GET STARTED ON JATENZO®
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Can't get it up... Ferritin that is. Blood issues after 5 years. HCG related question. Labs attached.
I have been on TC for over 5 years with varying results, mostly positive until the last year. I have had to do a few blood donations within the last 3 years due to rising HCT. It dropped my ferritin levels to 10, range 30 - 400. I can't get my ferritin levels up. My Mayo PCP said that if I take...
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Kyzatrex or Jatenzo
Good day all. I've been on testosterone cypionate almost 7 years. I inject anywhere from 100 to 120 mg in total divided 2 times a week. Am 47. I'm feeling good consistently for years now. Looks like my insurance cover oral testosterone. I did read some threads on here, I see system Lord is...
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Nelson Vergel
Founder, ExcelMale.com
I think Kyzatrex's manufacturer set theirs up to $125/month self-pay. You can access doctors here: Get Started | Why Kyzatrex | Safe, Easy, Up to 96% Effective
madman
Super Moderator
Possible dose titration (Jatenzo or Kyzatrex) needs to be kept in mind when it comes to the cost as not everyone will fare well or hit a high enough T level with the starting doses.
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Dose and impact of baseline characteristics.
The distribution of final doses is provided in Figure 3. The logistic regression analysis of the impact of baseline characteristics on final dose demonstrated that body weight and diabetic status were positively associated with higher final dose (⩽400, 600, or 800mg) with odds ratios of 3.928 (95% CI: 1.896–8.137) and 2.646 (95% CI: 1.111–6.300), respectively. In contrast, use of antihypertensive medication had no influence on final dose.
Figure 3. Final dose distributions after 90 days of treatment with KYZATREX
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*Overall, 316 mg TU BID quickly and effectively increased serum T concentrations above 450 ng/dL in 77% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 23% <450 ng/dL and 27% 1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.
A phase III, single-arm, 6-month trial of a wide-dose range oral TU (Kyzatrex) product
Abstract Background Oral testosterone undecanoate (TU) formulations may provide effective, safe, and easily titratable testosterone replacement therapy. Objective Demonstrate efficacy and safety of a novel oral TU formulation. Design An open-label, single-arm, multi-center trial treated...
www.excelmale.com
Dose and impact of baseline characteristics.
The distribution of final doses is provided in Figure 3. The logistic regression analysis of the impact of baseline characteristics on final dose demonstrated that body weight and diabetic status were positively associated with higher final dose (⩽400, 600, or 800mg) with odds ratios of 3.928 (95% CI: 1.896–8.137) and 2.646 (95% CI: 1.111–6.300), respectively. In contrast, use of antihypertensive medication had no influence on final dose.
Figure 3. Final dose distributions after 90 days of treatment with KYZATREX
ORAL TU (316 MG BID) QUICKLY AND EFFECTIVELY INCREASES SERUM T CONCENTRATIONS IN HYPOGONADAL MEN
INTRODUCTION AND OBJECTIVE Over 2.4 million US men have hypogonadism, defined as serum testosterone (T) levels
www.excelmale.com
*Overall, 316 mg TU BID quickly and effectively increased serum T concentrations above 450 ng/dL in 77% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 23% <450 ng/dL and 27% 1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.
Nelson Vergel
Founder, ExcelMale.com
Marius Pharmaceuticals Submits KYZATREX® (oral TU) CIII Capsules for Approval to Health Canada
It was just a matter of time! F**king A! Looks like they may have beat out Verity Pharmaceuticals oral Tlando for dibs on the Canadian market! RALEIGH, N.C., July 30, 2024 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals, a patient-centric healthcare company focused on developing innovative...
www.excelmale.com
madman
Super Moderator
Possible dose titration (Jatenzo or Kyzatrex) needs to be kept in mind when it comes to the cost as not everyone will fare well or hit a high enough T level with the starting doses.
A phase III, single-arm, 6-month trial of a wide-dose range oral TU (Kyzatrex) product
Abstract Background Oral testosterone undecanoate (TU) formulations may provide effective, safe, and easily titratable testosterone replacement therapy. Objective Demonstrate efficacy and safety of a novel oral TU formulation. Design An open-label, single-arm, multi-center trial treated...
Dose and impact of baseline characteristics.
The distribution of final doses is provided in Figure 3. The logistic regression analysis of the impact of baseline characteristics on final dose demonstrated that body weight and diabetic status were positively associated with higher final dose (⩽400, 600, or 800mg) with odds ratios of 3.928 (95% CI: 1.896–8.137) and 2.646 (95% CI: 1.111–6.300), respectively. In contrast, use of antihypertensive medication had no influence on final dose.
Figure 3. Final dose distributions after 90 days of treatment with KYZATREX
View attachment 45318
ORAL TU (316 MG BID) QUICKLY AND EFFECTIVELY INCREASES SERUM T CONCENTRATIONS IN HYPOGONADAL MEN
INTRODUCTION AND OBJECTIVE Over 2.4 million US men have hypogonadism, defined as serum testosterone (T) levels
*Overall, 316 mg TU BID quickly and effectively increased serum T concentrations above 450 ng/dL in 77% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 23% <450 ng/dL and 27% 1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.
View attachment 45307
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View attachment 45310
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Oral TU Quickly and Effectively Achieves Serum Testosterone ≥300 NG/DL in Most Hypogonadal Men Without Dose Titrations
* Overall, the starting dose of 237 mg TU BID quickly and effectively increased serum T concentrations ≥300 ng/dL in 85% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 15%
www.excelmale.com
Conclusions:
Overall, the starting dose of 237 mg TU BID quickly and effectively increased serum T concentrations ≥300 ng/dL in 85% of hypogonadal men. The wide distribution of serum T concentrations for the same dose (e.g., 15% <300 ng/d and 12% ≥1000 ng/dL) suggests that men likely respond differently to T replacement therapy. Therefore, an oral T replacement therapy that allows for dose titration would likely be preferable to a fixed dose. Future studies and investigations should evaluate patient factors that impact the magnitude of T increases allowing for more individualized titrations.
madman
Super Moderator
Understanding Testosterone and Muscle Preservation
Never heard about oral TU LOL! In this episode of The Dr. Gabrielle Lyon Show, Dr. Lyon sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to explore the science, benefits, and future of testosterone therapy. Shalin has been a driving force behind bringing Kyzatrex, an FDA-approved...
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00:29:13 - Oral vs Injectable Testosterone: Benefits and Comparisons
01:05:55 - Kyzatrex: A New Approach to Testosterone Delivery
If your goal is to minimize chances of driving up hematocrit let alone hitting a high-end short-lived daily peak twice daily then 400 mg BID is most likely the way to achieve such unless you are one of those hyper responders who will fare well on a lower daily dose!
High-Dose Oral TU Kyzatrex in Men with Low Testosterone: Safety, Efficacy, and Patient Satisfaction
Hot off the press! You heard it here first, Nelson's domain is where it's at! High-dosed oral TU (Kyzatrex 400 mg) BID, LH/FSH while lower were maintained at non-zero levels, minimal impact on hematocrit! *At a mean follow up time of 6 months, patients demonstrated a significant increase in...
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*At a mean follow up time of 6 months, patients demonstrated a significant increase in TT (263 to 798 ng/dL), drop in SHBG (32.4 to 17.83 nmol/L), and increase in calculated fT (7.24 to 26.74 ng/dL). FSH and LH, while lower, were maintained at non-zero levels (FSH from 5.7 to 2.9 mIU/mL and LH from 3.3 to 1.9 mIU/mL). Estradiol modestly increased (20.5 to 24.7 pg/mL) while hematocrit did not significantly increase (44.9% to 47.4%). No patients reported testicular atrophy or were initiated on aromatase inhibitors. One patient had a hematocrit rise above 52% (53.2%) and was reduced to 300 mg BID.
* Initiating oral TU therapy with Kyzatrex at 400 mg BID is safe and effective in achieving therapeutic serum testosterone levels. The high dose was well-tolerated and resulted in substantial symptom improvement, high patient satisfaction, and adherence. These findings support considering a higher starting dose for hypogonadal men considering oral TU therapy.
Best possible method of Minimizing Erythrocytosis during TRT (Daily injectables vs. Gels vs. Kyzatrex)
All, I react very badly to injectable T (56 hematocrit @ 100 mg split 3x per week SubQ). My ferritin suffers greatly here and sits in the 20's to low 30's. I want it to be above 70. Testosterone have given me a severe case of periodic limb movement disorder due to low dopamine resulting (I...
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