Less than 50 mg of T per week

[Melody68]

That's basically argument from authority. They may simply be responding to the demands of their customers, who by and large have more-is-better thinking. I see that @Willyt has already mentioned Xyosted. Its success dispels the notion that supra-physiological doses are needed to ameliorate symptoms of hypogonadism. The main thing I object to is starting new patients on 100+ mg TC/week when many will be harmed by this practice.

There is an evolution-based argument in favor of targeting average serum levels for healthy young men, which can be the 600-700 ng/dL figure of earlier decades, predating the recent decline. The reasoning is that nature had selected those levels as optimal for reproductive success. Reproductive success is then suggested to be a decent proxy for overall success in life; you have the resources and skills to attract a mate and ensure the survival of the resulting offspring. So in the end this gets you back to those physiological doses of testosterone, around 3-9 mg/day.

I'm one of these layperson guys that does well on a smaller dose, probably around 70mg/week. That puts me in the Cataceous camp of thinking. One concern I've always had is that, acknowledging the ideal of 4-8 mg/day that young men produce and use, it seems likely to me that our pathway of T delivery via injecting into the muscle or subcutaneous fat is no where near as efficient as what nature provides. Perhaps, when we inject IM we have to inject more T into the muscle to finally net out to the same 4-8mg that naturally arrives at the necessary sites for use by the young man. If that were true then higher daily allotments of 10, 12, 14 or more mg/day might be necessary . . .