Recent content by Cataceous

Still a ways off with the Phase 2A trial just getting started. If it continues to look good then it may show up on research chemical sites before FDA approval, depending on its legal status.

Natesto has the evidence behind it. It's the only form of TRT proven to allow continued HPTA function, which in my mind makes it more physiological. Oral forms cause more complete suppression unless accompanied by a SERM. It's likely that appropriately dosed buccal troches would be similar in...

It comes as 100 mg/mL, but I dilute it to 50 mg/mL for quarter-milligram dose resolution.

Suspensions are water-based. In this case there are micronized testosterone particles suspended in the carrier; being hydrophobic they do not dissolve as they would in oil. The injections are spaced six hours apart. No blood work yet, but I am seriously considering doing a sequence of tests to...

The slower the transition, the less the likelihood of side effects. If you limit the reduction to a few milligrams per week then you may not even notice it. But then it will take a few months to complete. With respect to anxiety, have you ever tested your serum progesterone? Frequently it is...

If your goal is primarily to be healthy then be aware that the maximum testosterone production in healthy young men is equivalent to 90-100 mg testosterone cypionate per week, and 60-70 mg is typical. By this standard you are vastly overdosed. The long-term consequences of this are uncertain. We...

Older men do get more "bang for the buck" from testosterone because the metabolic clearance rate declines with age. That is, free testosterone will typically go higher at the same dose as we age. There is no evidence that high levels of testosterone are healthier or to be preferred in any way...

I agree that estradiol is the stronger regulator, but we typically observe that enclomiphene fails to stimulate the HPTA under conventional TRT. This is most likely due to the direct negative feedback of androgens on kisspeptin neurons in the arcuate nucleus. I've suggested that using cistanche...

You have my sympathy. Having experienced something similar, I think people fail to appreciate the dramatic effects menopause can have on some women. It goes well beyond libido, perhaps affecting feelings of empathy and connectedness to significant others. Nominally my wife divorced me because I...

It might work in some healthy individuals, but it's more of a stretch for those suffering from secondary hypogonadism, who have a reduced natural set point for testosterone. A crude estimate based on an 18 hour half-life is that propionate still leads to a trough that's 40% of the peak. I...

Your one measurement is already more useful than any guesswork I might provide, especially if we assume a fair amount of individual variability. To me it says that lowering the dose to 150 IU hCG EOD has a decent chance of reducing suppression to the point where LH is at least low-normal.

Are you thinking that any potential return on their risky investment should be limited by your definition of fairness rather than by the free choices of buyers and sellers? That's been tried and it was a colossal failure.

That's highly dependent on the doses involved. DHT can inhibit aromatase, so at high enough levels there could be a noticeable effect on estradiol, but still nothing like a dedicated aromatase inhibitor. The dose of hCG also matters. At lower doses the HPTA may not be fully suppressed, implying...

I think it's more a matter of semantics. It is true that esters slow the release of testosterone, and that once released from the esters the testosterone molecules are indistinguishable from others, regardless of source. I do not believe @madman is arguing that differing pharmacokinetics do not...

At least in the past I recall that they used the ratio of testosterone to epitestosterone to reveal doping. It's stated that an abnormal T/E ratio can also be indicative of the use of exogenous DHT. Epitestosterone is an inactive epimer of testosterone that is naturally produced in equal...