Stroke-Related Mortality at Different Altitudes: A 17-Year Nationwide Population-Based Analysis From Ecuador.

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Living at higher elevation with higher hematocrit may decrease cardiovascular risk!

Stroke-Related Mortality at Different Altitudes: A 17-Year Nationwide Population-Based Analysis From Ecuador - PMC

Introduction: Worldwide, more than 5.7% of the population reside above 1,500 m of elevation. It has been hypothesized that acute short-term hypoxia exposure could increase the risk of developing a stroke. Studies assessing the effect of altitude on ...

www.ncbi.nlm.nih.gov

PubMed Central Image Viewer.

 

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Recent data implies an optimum altitude and further elevation increase can be problematic.

With respect to TRT comes back to the hematocrit ---> whole blood viscosity at the individual level.

Chronic high-altitude exposure and the epidemiology of ischaemic stroke: a systematic review | BMJ Open

 

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Hypoxia and hemorheological properties in older individuals

Hypoxia is caused by insufficient oxygen availability for the organism leading to reduced oxygen delivery to tissues and cells. It has been regarded a…

www.sciencedirect.com

 

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Crash course before you fall for the "erythrocytosis is harmless" bit.

Hct+plasma viscosity set whole blood viscosity.

Blood rheology and aging - PMC

The flow properties of blood play significant roles in tissue perfusion by contributing to hydrodynamic resistance in blood vessels. These properties are influenced by pathophysiological processes, thereby increasing the clinical relevance of blood ...

www.ncbi.nlm.nih.gov

 

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Get your hands on this oldie but goodie! Excellent review.

Modifications of blood rheology during aging and age- related pathological conditions - Aging Clinical and Experimental Research

In principle there should not be any increase of blood viscosity factors (plasma viscosity, blood viscosity, aggregation of red blood cells, rigidity of red blood cells, dynamic thrombus formation) with aging in a healthy population. Such an increase would be due to pathological caused and not...

link.springer.com

 

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