Semaglutide Forum: Game Changer for Weight Loss

[Nelson Vergel]

Highly Successful Weight Loss Drug Semaglutide Explained

A transcript of this podcast and more information about Tom Wadden is available on the website of the Duke World Food Policy Center at https://wfpc.sanford.duke.edu/podcast... Much attention has been paid recently in both scientific circles and in the media to a drug for weight loss newly...

www.excelmale.com

Semaglutide: Preventing/Dealing with Side Effects

Hi all! I just received my Semaglutide medicine. I am planning to take it later today for the first time. I am excited about it (due to the fact that I have always had weight issues my entire life) but also very nervous (because I tend to have GI issues easily, usually in the form of...

www.excelmale.com

 

[Whitey26]

Would you people please speak with an endocrinologist and stop the bro science. These medicines can’t be compounded and they have no effect on the leptin production in the body.

 

[Whitey26]

I read somewhere that Semaglutide produces antibodies which make it less effective as time goes on. I’m concerned about anything that has the potential to form antibodies because we don’t know the long term effects of how this plays out on our bodies. Any thoughts on this?

About 3% will develop antibody titers

 

[captain]

Semaglutide / Cyanocobalamin Injection

Choose Empower Pharmacy for compounded Semaglutide / Cyanocobalamin Injection. The leading accredited 503A and FDA-registered 503B compounding pharmacy.

www.empowerpharmacy.com

What is this if it can't be compounded?

 

[Deleted member 43589]

I guess I need to re-post thispap0per?

Semaglutide Forum: Game Changer for Weight Loss

Semaglutide is a glucagon like peptide-1 which consists of at least 30-31 amino acids technically called a polypeptide. Since it is pretty short, it is considered to be very stable because they go through the lyophilization process in which water is removed from a product after it is frozen and...

www.excelmale.com

 

[Deleted member 43589]

Semaglutide / Cyanocobalamin Injection

Choose Empower Pharmacy for compounded Semaglutide / Cyanocobalamin Injection. The leading accredited 503A and FDA-registered 503B compounding pharmacy.

www.empowerpharmacy.com

What is this if it can't be compounded?

I drove by Empower yesterday going out of town its not so far from my house.. They have a huge complex off of Beltway 8 close to the horse racing track. I have to fine the time to go by there and ask for a tour.

 

[Deleted member 43589]

Here is a link to the patend of semiglutide synthesis

I have two friends that both are very experienced in peptides synthization. Both own their own equipment and have even produced hGH. I promise if you have the knnowledge, thisis not very hard to reproduce with the proper equipment.

US Patent Application for CHEMO-ENZYMATIC SYNTHESIS OF SEMAGLUTIDE, LIRAGLUTIDE AND GLP-1 Patent Application (Application #20190345529 issued November 14, 2019) - Justia Patents Search

A method for synthesizing a peptide having the sequence His-X-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Y-Glu-Phe-Ile-Ala-Trp-Leu-Val-Z-Gly-Arg-Gly is disclosed. The method includes enzymatically coupling: (a) a peptide C-terminal ester or thioester having a first...

patents.justia.com

Several peptides comprising the amino acid sequence H-His-X-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Y-Glu-Phe-Ile-Ala-Trp-Leu-Val-Z-Gly-Arg-Gly-OH are well known in the art as insulinotropic peptides. These peptides include GLP-1, Liraglutide and Semaglutide.

Human GLP-1 (Glucagon-like peptide-1) has the formula H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-Gly-OH.

Liraglutide is an Arg20-GLP-1 analogue substituted on the ε-amino group of the lysine in position 20 of the above sequence with a Glu-spaced palmitic acid. Thus, Liraglutide has the formula H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(Pal-γ-Glu)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH (see also FIG. 1, all chiral amino acid residues are L-amino acid residues). In Lys(Pal-γ-Glu) the ε-amino-group of the Lys residue is linked with the γ-Glu carboxylic side-chain and the Glu is N-palmitoylated.

Semaglutide has the formula H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH. Herein AEEA-AEEA-γ-Glu-17-carboxyheptadecanoyl is N-(17-carboxy-I-oxoheptadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl-2-[2-(2-aminoethoxy)ethoxy]acetyl (see also FIG. 2, all chiral amino acid residues are L-amino acid residues).

These peptides can, e.g., be used in the treatment of diabetes II. Further, e.g., Liraglutide can be used in the treatment of obesity, as injectable adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adult patients.

Here is another good paper on the current manufacturing of peptides

Commercial manufacturing of current good manufacturing practice peptides spanning the gamut from neoantigen to commercial large-scale products

Peptide therapeutics represents a significant and growing area for manufacturing companies utilizing both chemical and recombinant methods. Approvals …

www.sciencedirect.com

 

[bixt]

Would you people please speak with an endocrinologist and stop the bro science. These medicines can’t be compounded and they have no effect on the leptin production in the body.

Big downvote

 

[Deleted member 43589]

About 3% will develop antibody titers

Here are the results of a step 2 clinical trial using semaglutide on obese adults for a 68 week period. No where did they find patients developed antibody titers.

This is the 2nd time antibody titers has been brought up and no one has bothered posting reference to this despite me asking. I am tying to have an open mind but I hesistate to get too excited over broscience. I prefer scientific data since it is available.

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Here is a clinical trial Phase 2 study, no mention of antibody titers. This is a 52 week study.

Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial

Obesity is a major public health issue, and new pharmaceuticals for weight management are needed. Therefore, we evaluated the efficacy and safety of t…

www.sciencedirect.com

Am I missing something?

 

[Deleted member 43589]

What we do know for sure is GLP-1 receptor agonist suppresse the hunger hormone, ghrelin. plasma active ghrelin diminished from 137.0 to 27.7 (pmol/L). The rate of gastrict emptying has a big effect on both leptin and ghrelin.

The glucagon-like peptide-1 analog liraglutide suppresses ghrelin and controls diabetes in a patient with Prader-Willi syndrome - PubMed

Prader-Willi syndrome (PWS) is a genetic disease characterized by severe morbid obesity in association with hyperphagia and type 2 diabetes mellitus. Liraglutide is a glucagon-like peptide (GLP)-1 analog that controls appetite, decreases body weight and improves glycemic control. However, it is...

pubmed.ncbi.nlm.nih.gov

Gastric emptying

Semaglutide causes a delay of early postprandial gastric emptying, thereby reducing the rate at which glucose appears in the circulation postprandially.

Here is a phase 3 trial.....the evidence is stacking up...68 weeks here.

Sci-Hub | Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. The Lancet, 397(10278), 971–984 | 10.1016/s0140-6736(21)00213-0

 

[Deleted member 43589]

Would you people please speak with an endocrinologist and stop the bro science. These medicines can’t be compounded and they have no effect on the leptin production in the body.

Interesting you mentioned an endocrinologist. Here in Houston we are well known for our good folks in the medical profession, we have a medical center that is one of the best in the world. My wife went to see an endocrinologist for hunger issues. He tested her blood and determined her cholesterol was high and put her on a statin. He never bother asking her what kind of diet she was on.....KETO. . This expert endocrinologist who charged $650 for his time has no clue the effect of a keto diet high in saturated fat on blood cholesterol levels, nor did he everey bother looking into the causeof the hunger issue. There was no need in a statin so we tossed the script in the garbage. Wonder how many endocrinologists have any clue how a peptide is synthesized?

Did you ever read the research paper my send me that is a biochemist and does do work synthesizing peptides, including semaglutide. Are you guilty of passing off bro science? So far you have not backed up and thing you have claimed.

Speaking of medicines.....Oxytocin is a peptide hormone and neuropeptide and was isolated from pituitary tissue in 1920 and 1st synthesized in 1952. This ...a medicine is not new science. Its amino acid sequence is Cys – Tyr – Ile – Gln – Asn – Cys – Pro – Leu – Gly – NH2 or CYIQNCPLG-NH2. Do you honestly believe that this could not be synthesided in a good lab? A good compounding pharmacy like EMPOWER would most likely have solid phase and/or the 3rd gen liquid phase peptide synthesis equipment?

Yes, Semaglutide is also classified as a medicine by also has a amino acid sequence. Once again, the products you claim you sell are reconstituted and must be refridgerated. They do not sell the raw powder form as 99.9% of the population would never be able to reconstitute, even with directions. The raw powder is much more stable since it is not reconstituted. But then I remember pointing that out to you.

Please get off the bro science and start producing some scentific evidence. The onus is on you.

Again

Highly Successful Weight Loss Drug Semaglutide Explained

A transcript of this podcast and more information about Tom Wadden is available on the website of the Duke World Food Policy Center at https://wfpc.sanford.duke.edu/podcast... Much attention has been paid recently in both scientific circles and in the media to a drug for weight loss newly...

www.excelmale.com

 

[JimGainz]

Here are the results of a step 2 clinical trial using semaglutide on obese adults for a 68 week period. No where did they find patients developed antibody titers.

This is the 2nd time antibody titers has been brought up and no one has bothered posting reference to this despite me asking. I am tying to have an open mind but I hesistate to get too excited over broscience. I prefer scientific data since it is available.

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Here is a clinical trial Phase 2 study, no mention of antibody titers. This is a 52 week study.

Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial

Obesity is a major public health issue, and new pharmaceuticals for weight management are needed. Therefore, we evaluated the efficacy and safety of t…

www.sciencedirect.com

Am I missing something?

Here is one reference from Drugs.com:

Immunologic​

Frequency not reported: Development of anti-semaglutide antibodies

As with other protein and peptide pharmaceuticals, patients receiving this drug have developed anti-semaglutide antibodies. The detection of antibody formation is highly dependent on the sensitivity and specificity of the assay, as well as other factor in handling of the sample. For these reasons, the incidence of antibodies cannot be directly compared with other products. Anti-drug antibodies to semaglutide have been reported in up to 1% of patients during clinical trials.

 

[Deleted member 43589]

<1% is pretty rare. Can't see this as a big concern. Too many large subject clinicals trials have show very good success with this stuff in 52-68 weeks. But thank you posting this. I have yet to see this mentioned anywhere in clinical trials.

 

[Nelson Vergel]

Semaglutide in Adolescents with Obesity

www.excelmale.com

 

[Deleted member 43589]

I know a guy who just bought a weight loss clinic. He is going to make a fortune. This stuff works far better than the phentermine.

 

[tareload]

I know a guy who just bought a weight loss clinic. He is going to make a fortune. This stuff works far better than the phentermine.

Let's hope it doesn't work as good as fenfluramine.

Fenfluramine/phentermine - Wikipedia

en.m.wikipedia.org

 

[tareload]

Let's hope it doesn't work as good as fenfluramine.

Fenfluramine/phentermine - Wikipedia

en.m.wikipedia.org

@BigTex I am holding my nose taking the escitalopram but so far so good.

Serotonin syndrome associated with the use of escitalopram - PubMed

Escitalopram is the newest selective serotonin reuptake inhibitor (SSRI) available for use in the United States. It has been approved for the treatment of major depression and generalized anxiety disorder. It is the S-enantiomer of the SSRI citalopram and is highly serotonin specific as it has...

pubmed.ncbi.nlm.nih.gov

 

[Deleted member 43589]

I still remember when fen-phen was sold locally. As soon as that was ended phentermine was took over. My wife used this stuff a few times but it seemed like after a month or so it just quit working.

We still have lots of weight loss clinics using this stuff. Cheap prices and no insurance accepted. $100 for the exam, blood work and 90 day prescription. Of course you have to pay extra to get the prescription filled.

 

[tareload]

My first post from People Mag:

Remi Bader Says She 'Gained Double the Weight Back' After Stopping Weight-Loss Drug Ozempic

The content creator and model, 27, opened up about her doctor prescribing the medication, and how it eventually made her binge eating worse

www.yahoo.com

And recent RCT:

Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension - PubMed

One year after withdrawal of once-weekly subcutaneous semaglutide 2.4 mg and lifestyle intervention, participants regained two-thirds of their prior weight loss, with similar changes in cardiometabolic variables. Findings confirm the chronicity of obesity and suggest ongoing treatment is...

pubmed.ncbi.nlm.nih.gov

Unless you have diabetes I am not sure why you would pull this lever simply to shortcut fat loss. No go. Would one stay on this for life instead of retraining their brain/metabolism/gut with the hard work?

 

[Deleted member 43589]

Exactly, this stuff is a quick fix. Life style changes are a BIG part of of losing weight. I am not sure most are being made aware of this.