Would grapefruit juice or bioperine increase Cialis effect?

[Mark David]

I take a 5mg daily of cialis which has been working fine. Just wondering if taking it with grapefruit juice or bioperine occasionally ( like on a Sunday morning), would increase its potency/effectiveness?

 

[madman]

I take a 5mg daily of cialis which has been working fine. Just wondering if taking it with grapefruit juice or bioperine occasionally ( like on a Sunday morning), would increase its potency/effectiveness?

Potential for Other Drugs to Affect CIALIS

Cytochrome P450 Inhibitors: CIALIS is a substrate of and principally metabolized by CYP3A4. Studies have shown that drugs that inhibit or induce CYP3A4 can alter tadalafil exposure

*Grapefruit juice being a weak inhibitor of CYP3A4 gut wall metabolism, MAY give rise to modest increases in plasma levels of tadalafil

*BioPerine® (extract) inhibits human CYP3A4 and P-glycoprotein enzymes. By inhibiting certain enzymes BioPerine® (extract) MAY alter the effectiveness of certain medications by increasing the bioavailability

 

[Guided_by_Voices]

There was a similar discussion several years ago here related to viagra. If you're going to try this, you would want to take the grapefruit juice a few hours in advance because if taken at the same time it can apparently block absorption, but once it is out of the stomach, the enzyme suppression continues and might enhance absorption. That said, I remember hearing a detailed discussion of Grapefruit juice and it can have a lot of unwanted affects on many different things if taken chronically, so you might be better off to just up your cialis dose.

 

[RCR1]

I’d add L-Citrulline twice a day. Make more NO2 naturally and get your blood flowing.

 

[LongevityNutritionDoc]

I’ve been studying nutrition and nutritional supplements for 45 years, and the best thing I’ve found so far is for increasing nitric oxide is red spinach extract. It works much better for most people than citrulline or arginine. Those amino acids can activate latent viruses that we all carry.

 

[t_spacemonkey]

it is absolute nonsense to try increasing a drug strength by adding a substance which will slow down its metabolism. just raise the dose. cialis is dirt cheap

 

[LongevityNutritionDoc]

PDE5 Inhibitors need nitric oxide to work. Increasing dosages of pharmaceuticals increases risk of side-effects. I would rather support my physiology as much as possible with a good diet and nutritional supplement and take the minimum effective dose of a pharmaceutical… if needed.

 

[MarkLA]

I’ve been studying nutrition and nutritional supplements for 45 years, and the best thing I’ve found so far is for increasing nitric oxide is red spinach extract. It works much better for most people than citrulline or arginine. Those amino acids can activate latent viruses that we all carry.

Do you have a brand you recommend? What about dosage?

Thank you!

 

[LongevityNutritionDoc]

Barlowe’s Herbal Elixers: Oxystorm N.O. Explosion.

One capsule is often all you need. Test your saliva with test strips (available on Amazon.com) to see where you are, and dose according to get yourself to and maintain an optimal level of nitric oxide.

 

[MarkLA]

Barlowe’s Herbal Elixers: Oxystorm N.O. Explosion.

One capsule is often all you need. Test your saliva with test strips (available on Amazon.com) to see where you are, and dose according to get yourself to and maintain an optimal level of nitric oxide.

Is there a brand of strips you like or are they all the same?

Would the idea be to measure the saliva in the morning upon waking and then take a capsule, then check the next morning to see what the change was? i.e. measure at trough? Then once a good dose is found, stay with it or is there a need to test ongoing?

Thanks much!

 

[LongevityNutritionDoc]

The strips are all pretty much the same, but you could always try a couple different brands to see how much of a difference there is between them - if any.

You can take one capsule before sleep and check levels the next morning.

You can also try taking one capsule in the morning and waiting 2 or 3 hours to re-test. Make sure you don’t eat or drink anything including water before testing.

Most people find once they have built up there reserved they can decrease dose… and verify everything with testing via the strips.

You’re welcome.

 

[sammmy]

I’ve been studying nutrition and nutritional supplements for 45 years, and the best thing I’ve found so far is for increasing nitric oxide is red spinach extract. It works much better for most people than citrulline or arginine. Those amino acids can activate latent viruses that we all carry.

Add to that list glutamine. It calms down intestinal mucosa and many people take it for upset stomach/intestines but there is an invivo study in humans that it converts to citruline and then to arginine in kidneys, which promotes replication of latent herpes viruses.

 

[Rvdave]

What about taking niacin for increased blood flow, does that have an affect on tadalafil or sildenafil?

 

[LongevityNutritionDoc]

Not sure. But there is this…

Effect of niacin on erectile function in men suffering erectile dysfunction and dyslipidemia - PubMed

Niacin alone can improve the erectile function in patients suffering from moderate to severe ED and dyslipidemia.

pubmed.ncbi.nlm.nih.gov

 

[SSHSSA74]

I’ve been studying nutrition and nutritional supplements for 45 years, and the best thing I’ve found so far is for increasing nitric oxide is red spinach extract. It works much better for most people than citrulline or arginine. Those amino acids can activate latent viruses that we all carry.

Interesting. Never heard of it.

 

[Dr.V.P.C.]

Potential for Other Drugs to Affect CIALIS

Cytochrome P450 Inhibitors: CIALIS is a substrate of and principally metabolized by CYP3A4. Studies have shown that drugs that inhibit or induce CYP3A4 can alter tadalafil exposure

*Grapefruit juice being a weak inhibitor of CYP3A4 gut wall metabolism, MAY give rise to modest increases in plasma levels of tadalafil

*BioPerine® (extract) inhibits human CYP3A4 and P-glycoprotein enzymes. By inhibiting certain enzymes BioPerine® (extract) MAY alter the effectiveness of certain medications by increasing the bioavailability

This makes me remember 25 y ago when viagra was released on the market (and was kind expensive), i used to take 1/4 of the pill with some ketoconazole or cimetidine and it last all the weekend.
Such good single times...

 

[wrongway]

Friday morning I drank about 4 oz of Grapefruit juice then Saturday evening I cut a 5mg Cialis in half. 10 minutes later I got a strong throbbing erection like a teenager that lasted just under 3 hrs without any kind of stimulation. That was quit fun but scary! Not sure what exactly happened but one article I read claims that Grapefruit juice causes fast absorption of the Cialis and that you should not cut the pill as its designed to release slowly.

 

[LongevityNutritionDoc]

One needs to be careful with grapefruit juice and pomegranate juice amongst others.