When I lived in Maryland, saw a psychiatrist who was also a researcher at National Institutes of Mental Health. In me she had a willing and eager lab rat, since there wasn't any drug I could take for my bipolar illness. She told me about LDN and she prescribed it. Took it at night as recommended. Messed up my already poor sleep and ramped up my immune system. Always felt like I had a low grade viral infection; scratchy throat, runny nose, fatigue. Tried it during the day. Not any better. But, I've read enough about it to know that for some or many people, it improves their health and gives them back their life.